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Pyrrolidine-thiourea as a bifunctional organocatalyst: highly enantioselective Michael addition of cyclohexanone to nitroolefins.
Org Lett. 2006 Jul 06; 8(14):2901-4.OL

Abstract

[reaction: see text] Asymmetric Michael additions of cyclohexanone to both aryl and alkyl nitroolefins in the presence of 20 mol % of organocatalyst 2b and 10 mol % of n-butyric acid afford adducts 5 with high diastereoselectivities and enantioselectivities.

Authors+Show Affiliations

Cao CL
The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
Ye MC
No affiliation info available
Sun XL
No affiliation info available
Tang Y
No affiliation info available

MeSH

AlkenesCatalysisCyclohexanonesMolecular StructureNitro CompoundsPyrrolidinesStereoisomerismThiourea

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16805512

Citation

Cao, Chun-Li, et al. "Pyrrolidine-thiourea as a Bifunctional Organocatalyst: Highly Enantioselective Michael Addition of Cyclohexanone to Nitroolefins." Organic Letters, vol. 8, no. 14, 2006, pp. 2901-4.
Cao CL, Ye MC, Sun XL, et al. Pyrrolidine-thiourea as a bifunctional organocatalyst: highly enantioselective Michael addition of cyclohexanone to nitroolefins. Org Lett. 2006;8(14):2901-4.
Cao, C. L., Ye, M. C., Sun, X. L., & Tang, Y. (2006). Pyrrolidine-thiourea as a bifunctional organocatalyst: highly enantioselective Michael addition of cyclohexanone to nitroolefins. Organic Letters, 8(14), 2901-4.
Cao CL, et al. Pyrrolidine-thiourea as a Bifunctional Organocatalyst: Highly Enantioselective Michael Addition of Cyclohexanone to Nitroolefins. Org Lett. 2006 Jul 6;8(14):2901-4. PubMed PMID: 16805512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pyrrolidine-thiourea as a bifunctional organocatalyst: highly enantioselective Michael addition of cyclohexanone to nitroolefins. AU - Cao,Chun-Li, AU - Ye,Meng-Chun, AU - Sun,Xiu-Li, AU - Tang,Yong, PY - 2006/6/30/pubmed PY - 2007/4/27/medline PY - 2006/6/30/entrez SP - 2901 EP - 4 JF - Organic letters JO - Org Lett VL - 8 IS - 14 N2 - [reaction: see text] Asymmetric Michael additions of cyclohexanone to both aryl and alkyl nitroolefins in the presence of 20 mol % of organocatalyst 2b and 10 mol % of n-butyric acid afford adducts 5 with high diastereoselectivities and enantioselectivities. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/16805512/Pyrrolidine_thiourea_as_a_bifunctional_organocatalyst:_highly_enantioselective_Michael_addition_of_cyclohexanone_to_nitroolefins_ L2 - https://doi.org/10.1021/ol060481c DB - PRIME DP - Unbound Medicine ER -