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Review of clinical trials using early acute intervention with oral triptans for migraine management.
Int J Clin Pract. 2006 Jun; 60(6):698-706.IJ

Abstract

Most of the data on triptan use are from clinical trials in which patients were instructed to wait until migraine headache pain was moderate/severe in intensity. In the real world, patients may hesitate to use a triptan until headache pain is moderate/severe because of the cost of these agents or limited supply allowed by their health service organisation. However, accumulating data indicate that early intervention with an oral triptan when headache pain is still mild may be the most effective acute treatment strategy. Economic analyses also support early triptan intervention in migraine attacks. Tolerability is expected to be particularly important in early intervention, as patients treating mild migraine pain may be more reluctant to risk adverse events. Thus, an agent selected for use as early intervention should have both a demonstrated efficacy in treating mild migraine headache and placebo-like tolerability. This article reviews retrospective and prospective clinical trials which investigated the use of triptans for early acute migraine therapy.

Authors+Show Affiliations

King's Headache Services, King's College Hospital, London, UK. drandydowson@dowsona.fsnet.co.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

16805756

Citation

Dowson, A J., et al. "Review of Clinical Trials Using Early Acute Intervention With Oral Triptans for Migraine Management." International Journal of Clinical Practice, vol. 60, no. 6, 2006, pp. 698-706.
Dowson AJ, Mathew NT, Pascual J. Review of clinical trials using early acute intervention with oral triptans for migraine management. Int J Clin Pract. 2006;60(6):698-706.
Dowson, A. J., Mathew, N. T., & Pascual, J. (2006). Review of clinical trials using early acute intervention with oral triptans for migraine management. International Journal of Clinical Practice, 60(6), 698-706.
Dowson AJ, Mathew NT, Pascual J. Review of Clinical Trials Using Early Acute Intervention With Oral Triptans for Migraine Management. Int J Clin Pract. 2006;60(6):698-706. PubMed PMID: 16805756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review of clinical trials using early acute intervention with oral triptans for migraine management. AU - Dowson,A J, AU - Mathew,N T, AU - Pascual,J, PY - 2006/6/30/pubmed PY - 2007/4/6/medline PY - 2006/6/30/entrez SP - 698 EP - 706 JF - International journal of clinical practice JO - Int J Clin Pract VL - 60 IS - 6 N2 - Most of the data on triptan use are from clinical trials in which patients were instructed to wait until migraine headache pain was moderate/severe in intensity. In the real world, patients may hesitate to use a triptan until headache pain is moderate/severe because of the cost of these agents or limited supply allowed by their health service organisation. However, accumulating data indicate that early intervention with an oral triptan when headache pain is still mild may be the most effective acute treatment strategy. Economic analyses also support early triptan intervention in migraine attacks. Tolerability is expected to be particularly important in early intervention, as patients treating mild migraine pain may be more reluctant to risk adverse events. Thus, an agent selected for use as early intervention should have both a demonstrated efficacy in treating mild migraine headache and placebo-like tolerability. This article reviews retrospective and prospective clinical trials which investigated the use of triptans for early acute migraine therapy. SN - 1368-5031 UR - https://www.unboundmedicine.com/medline/citation/16805756/Review_of_clinical_trials_using_early_acute_intervention_with_oral_triptans_for_migraine_management_ DB - PRIME DP - Unbound Medicine ER -