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Ondansetron or droperidol for prophylaxis of nausea and vomiting after intrathecal morphine.
Eur J Anaesthesiol. 2006 Aug; 23(8):670-5.EJ

Abstract

BACKGROUND AND OBJECTIVE

There is a controversy regarding the best drug for prevention of nausea and vomiting in patients receiving intrathecal morphine. The aim of this study was to examine efficacy and tolerability of droperidol compared with ondansetron for the prevention of morphine-induced nausea and vomiting.

METHODS

In a randomized, placebo-controlled trial, 120 women undergoing Caesarean section under spinal anaesthesia with intrathecal morphine 0.1 mg received intravenous ondansetron 4 mg (n = 40), droperidol 1.25 mg (n = 40) or saline (n = 40) immediately after umbilical-cord clamping. Nausea and vomiting were graded according to intensity at 1, 2, 4, 6, 12 and 24 h.

RESULTS

Nausea or vomiting occurred in 14 patients (35%) in the placebo group, 4 (10%) in the ondansetron group and 10 (25%) in the droperidol group; the difference between ondansetron and placebo was statistically significant (P = 0.007). Eleven of the 14 placebo patients (27.5%) vomited, compared with none of the 4 ondansetron patients (vs. placebo, P = 0.0004) and 5 of the droperidol patients (vs. placebo, P = 0.18). Three of the 14 placebo patients (7.5%) were nauseous, compared with 4 (10%) receiving ondansetron and 5 (12.5%) receiving droperidol.

CONCLUSIONS

Ondansetron was effective in reducing the incidence of nausea and vomiting in patients receiving intrathecal morphine for Caesarean section.

Authors+Show Affiliations

Hospital de Caridade, Department of Anaesthesiology, Erechim, Brazil. peixoto@st.com.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16805932

Citation

Peixoto, A J., et al. "Ondansetron or Droperidol for Prophylaxis of Nausea and Vomiting After Intrathecal Morphine." European Journal of Anaesthesiology, vol. 23, no. 8, 2006, pp. 670-5.
Peixoto AJ, Celich MF, Zardo L, et al. Ondansetron or droperidol for prophylaxis of nausea and vomiting after intrathecal morphine. Eur J Anaesthesiol. 2006;23(8):670-5.
Peixoto, A. J., Celich, M. F., Zardo, L., & Peixoto Filho, A. J. (2006). Ondansetron or droperidol for prophylaxis of nausea and vomiting after intrathecal morphine. European Journal of Anaesthesiology, 23(8), 670-5.
Peixoto AJ, et al. Ondansetron or Droperidol for Prophylaxis of Nausea and Vomiting After Intrathecal Morphine. Eur J Anaesthesiol. 2006;23(8):670-5. PubMed PMID: 16805932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ondansetron or droperidol for prophylaxis of nausea and vomiting after intrathecal morphine. AU - Peixoto,A J, AU - Celich,M F, AU - Zardo,L, AU - Peixoto Filho,A J, PY - 2006/02/08/accepted PY - 2006/6/30/pubmed PY - 2007/12/15/medline PY - 2006/6/30/entrez SP - 670 EP - 5 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 23 IS - 8 N2 - BACKGROUND AND OBJECTIVE: There is a controversy regarding the best drug for prevention of nausea and vomiting in patients receiving intrathecal morphine. The aim of this study was to examine efficacy and tolerability of droperidol compared with ondansetron for the prevention of morphine-induced nausea and vomiting. METHODS: In a randomized, placebo-controlled trial, 120 women undergoing Caesarean section under spinal anaesthesia with intrathecal morphine 0.1 mg received intravenous ondansetron 4 mg (n = 40), droperidol 1.25 mg (n = 40) or saline (n = 40) immediately after umbilical-cord clamping. Nausea and vomiting were graded according to intensity at 1, 2, 4, 6, 12 and 24 h. RESULTS: Nausea or vomiting occurred in 14 patients (35%) in the placebo group, 4 (10%) in the ondansetron group and 10 (25%) in the droperidol group; the difference between ondansetron and placebo was statistically significant (P = 0.007). Eleven of the 14 placebo patients (27.5%) vomited, compared with none of the 4 ondansetron patients (vs. placebo, P = 0.0004) and 5 of the droperidol patients (vs. placebo, P = 0.18). Three of the 14 placebo patients (7.5%) were nauseous, compared with 4 (10%) receiving ondansetron and 5 (12.5%) receiving droperidol. CONCLUSIONS: Ondansetron was effective in reducing the incidence of nausea and vomiting in patients receiving intrathecal morphine for Caesarean section. SN - 0265-0215 UR - https://www.unboundmedicine.com/medline/citation/16805932/Ondansetron_or_droperidol_for_prophylaxis_of_nausea_and_vomiting_after_intrathecal_morphine_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16805932.ui DB - PRIME DP - Unbound Medicine ER -