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Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice.
Neuropharmacology. 2006 Sep; 51(3):612-22.N

Abstract

We have previously shown that antinociceptive effects of morphine are enhanced in histamine H1 receptor gene knockout mice. In the present study, involvement of supraspinal histamine H2 receptor in antinociception by morphine was examined using histamine H2 receptor gene knockout (H2KO) mice and histamine H2 receptor antagonists. Antinociception was evaluated by assays for thermal (hot-plate, tail-flick and paw-withdrawal tests), mechanical (tail-pressure test) and chemical (formalin and capsaicin tests) stimuli. Thresholds for pain perception in H2KO mice were higher than wild-type mice. Antinociceptive effects of intracerebroventricularly administered morphine were enhanced in the H2KO mice compared to wild-type mice. Intracerebroventricular co-administration of morphine and cimetidine produced significant antinociceptive effects in the wild-type mice when compared to morphine or cimetidine alone. Furthermore, zolantidine, a selective and hydrophobic H2 receptor antagonist, enhanced the effects of morphine in all nociceptive assays examined. These results suggest that histamine exerts inhibitory effects on morphine-induced antinociception through H2 receptors at the supraspinal level. Our present and previous studies suggest that H1 and H2 receptors cooperatively function to modulate pain perception in the central nervous system.

Authors+Show Affiliations

Department of Pharmacology, Tohoku University Graduate School of Medicine, Seiryo-machi 2-1, Aoba-Ku, Sendai 980-8575, Japan. jalalizadi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16806305

Citation

Mobarakeh, Jalal Izadi, et al. "Enhanced Antinociceptive Effects of Morphine in Histamine H2 Receptor Gene Knockout Mice." Neuropharmacology, vol. 51, no. 3, 2006, pp. 612-22.
Mobarakeh JI, Takahashi K, Sakurada S, et al. Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice. Neuropharmacology. 2006;51(3):612-22.
Mobarakeh, J. I., Takahashi, K., Sakurada, S., Kuramasu, A., & Yanai, K. (2006). Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice. Neuropharmacology, 51(3), 612-22.
Mobarakeh JI, et al. Enhanced Antinociceptive Effects of Morphine in Histamine H2 Receptor Gene Knockout Mice. Neuropharmacology. 2006;51(3):612-22. PubMed PMID: 16806305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice. AU - Mobarakeh,Jalal Izadi, AU - Takahashi,Kazuhiro, AU - Sakurada,Shinobu, AU - Kuramasu,Atsuo, AU - Yanai,Kazuhiko, Y1 - 2006/06/23/ PY - 2005/09/01/received PY - 2006/04/18/revised PY - 2006/05/04/accepted PY - 2006/6/30/pubmed PY - 2006/12/15/medline PY - 2006/6/30/entrez SP - 612 EP - 22 JF - Neuropharmacology JO - Neuropharmacology VL - 51 IS - 3 N2 - We have previously shown that antinociceptive effects of morphine are enhanced in histamine H1 receptor gene knockout mice. In the present study, involvement of supraspinal histamine H2 receptor in antinociception by morphine was examined using histamine H2 receptor gene knockout (H2KO) mice and histamine H2 receptor antagonists. Antinociception was evaluated by assays for thermal (hot-plate, tail-flick and paw-withdrawal tests), mechanical (tail-pressure test) and chemical (formalin and capsaicin tests) stimuli. Thresholds for pain perception in H2KO mice were higher than wild-type mice. Antinociceptive effects of intracerebroventricularly administered morphine were enhanced in the H2KO mice compared to wild-type mice. Intracerebroventricular co-administration of morphine and cimetidine produced significant antinociceptive effects in the wild-type mice when compared to morphine or cimetidine alone. Furthermore, zolantidine, a selective and hydrophobic H2 receptor antagonist, enhanced the effects of morphine in all nociceptive assays examined. These results suggest that histamine exerts inhibitory effects on morphine-induced antinociception through H2 receptors at the supraspinal level. Our present and previous studies suggest that H1 and H2 receptors cooperatively function to modulate pain perception in the central nervous system. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/16806305/Enhanced_antinociceptive_effects_of_morphine_in_histamine_H2_receptor_gene_knockout_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(06)00128-6 DB - PRIME DP - Unbound Medicine ER -