Tags

Type your tag names separated by a space and hit enter

Protocatechuic acid suppresses MPP+ -induced mitochondrial dysfunction and apoptotic cell death in PC12 cells.
Food Chem Toxicol. 2006 Oct; 44(10):1659-66.FC

Abstract

Protocatechuic acid (PCA), a phenolic compound isolated from the kernels of Alpinia (A.) oxyphylla, showed antioxidant neuroprotective effect in our previous study. Here, we investigated the effect of PCA on the MPP(+)-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells. The apoptosis in MPP(+)-induced PC12 cells was associated with loss of mitochondrial membrane potential, the formation of reactive oxygen species (ROS), GSH depletion, activation of caspase-3 and down-regulation of Bcl-2. In contrast, treatment of PC12 cells with PCA significantly prevented the above-mentioned mitochondrial dysfunction. Our data pointed to the potential clinical application/use of PCA to overcome neurodegenerative diseases such as Parkinson's disease.

Authors+Show Affiliations

Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16806628

Citation

Guan, S, et al. "Protocatechuic Acid Suppresses MPP+ -induced Mitochondrial Dysfunction and Apoptotic Cell Death in PC12 Cells." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 44, no. 10, 2006, pp. 1659-66.
Guan S, Jiang B, Bao YM, et al. Protocatechuic acid suppresses MPP+ -induced mitochondrial dysfunction and apoptotic cell death in PC12 cells. Food Chem Toxicol. 2006;44(10):1659-66.
Guan, S., Jiang, B., Bao, Y. M., & An, L. J. (2006). Protocatechuic acid suppresses MPP+ -induced mitochondrial dysfunction and apoptotic cell death in PC12 cells. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 44(10), 1659-66.
Guan S, et al. Protocatechuic Acid Suppresses MPP+ -induced Mitochondrial Dysfunction and Apoptotic Cell Death in PC12 Cells. Food Chem Toxicol. 2006;44(10):1659-66. PubMed PMID: 16806628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protocatechuic acid suppresses MPP+ -induced mitochondrial dysfunction and apoptotic cell death in PC12 cells. AU - Guan,S, AU - Jiang,B, AU - Bao,Y M, AU - An,L J, Y1 - 2006/05/17/ PY - 2006/01/06/received PY - 2006/04/26/revised PY - 2006/05/05/accepted PY - 2006/6/30/pubmed PY - 2006/10/6/medline PY - 2006/6/30/entrez SP - 1659 EP - 66 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 44 IS - 10 N2 - Protocatechuic acid (PCA), a phenolic compound isolated from the kernels of Alpinia (A.) oxyphylla, showed antioxidant neuroprotective effect in our previous study. Here, we investigated the effect of PCA on the MPP(+)-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells. The apoptosis in MPP(+)-induced PC12 cells was associated with loss of mitochondrial membrane potential, the formation of reactive oxygen species (ROS), GSH depletion, activation of caspase-3 and down-regulation of Bcl-2. In contrast, treatment of PC12 cells with PCA significantly prevented the above-mentioned mitochondrial dysfunction. Our data pointed to the potential clinical application/use of PCA to overcome neurodegenerative diseases such as Parkinson's disease. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/16806628/Protocatechuic_acid_suppresses_MPP+__induced_mitochondrial_dysfunction_and_apoptotic_cell_death_in_PC12_cells_ DB - PRIME DP - Unbound Medicine ER -