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Endocannabinoid signaling directs periimplantation events.
AAPS J 2006; 8(2):E425-32AJ

Abstract

An emerging concept in female reproduction is the role of endocannabinoids, a group of endogenously produced lipid mediators that bind to and activate cannabinoid receptors. Although adverse effects of cannabinoids in female reproduction have been implicated for years, the mechanisms by which they exert these effects remained elusive. With the identification of cannabinoid receptors, endocannabinoid ligands, their key synthetic and hydrolytic pathways, and the generation of knockout mouse models for cannabinoid receptors, a wealth of information is now available regarding the significance of cannabinoid/endocannabinoid signaling in early pregnancy. This review focuses on various aspects of endocannabinoid signaling in preimplantation embryo development and activation, and uterine differentiation during the periimplantation embryo-uterine dialog. It is hoped that a deeper understanding will lead to potential clinical applications of the endocannabinoid system as a target for regulating female fertility.

Authors+Show Affiliations

Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232-2678, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16808046

Citation

Wang, Haibin, et al. "Endocannabinoid Signaling Directs Periimplantation Events." The AAPS Journal, vol. 8, no. 2, 2006, pp. E425-32.
Wang H, Xie H, Dey SK. Endocannabinoid signaling directs periimplantation events. AAPS J. 2006;8(2):E425-32.
Wang, H., Xie, H., & Dey, S. K. (2006). Endocannabinoid signaling directs periimplantation events. The AAPS Journal, 8(2), pp. E425-32.
Wang H, Xie H, Dey SK. Endocannabinoid Signaling Directs Periimplantation Events. AAPS J. 2006;8(2):E425-32. PubMed PMID: 16808046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocannabinoid signaling directs periimplantation events. AU - Wang,Haibin, AU - Xie,Huirong, AU - Dey,Sudhansu K, PY - 2006/7/1/pubmed PY - 2006/8/12/medline PY - 2006/7/1/entrez SP - E425 EP - 32 JF - The AAPS journal JO - AAPS J VL - 8 IS - 2 N2 - An emerging concept in female reproduction is the role of endocannabinoids, a group of endogenously produced lipid mediators that bind to and activate cannabinoid receptors. Although adverse effects of cannabinoids in female reproduction have been implicated for years, the mechanisms by which they exert these effects remained elusive. With the identification of cannabinoid receptors, endocannabinoid ligands, their key synthetic and hydrolytic pathways, and the generation of knockout mouse models for cannabinoid receptors, a wealth of information is now available regarding the significance of cannabinoid/endocannabinoid signaling in early pregnancy. This review focuses on various aspects of endocannabinoid signaling in preimplantation embryo development and activation, and uterine differentiation during the periimplantation embryo-uterine dialog. It is hoped that a deeper understanding will lead to potential clinical applications of the endocannabinoid system as a target for regulating female fertility. SN - 1550-7416 UR - https://www.unboundmedicine.com/medline/citation/16808046/Endocannabinoid_signaling_directs_periimplantation_events_ L2 - https://dx.doi.org/10.1007/bf02854916 DB - PRIME DP - Unbound Medicine ER -