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Enhancement of non-dominant hand motor function by anodal transcranial direct current stimulation.
Neurosci Lett 2006; 404(1-2):232-6NL

Abstract

Transcranial direct current stimulation (tDCS) is a non-invasive powerful method to modulate brain activity. It can enhance motor learning and working memory in healthy subjects. To investigate the effects of anodal tDCS (1 mA, 20 min) of the dominant and non-dominant primary motor cortex (M1) on hand motor performance in healthy right-handed volunteers, healthy subjects underwent one session of both sham and active anodal stimulation of the non-dominant or dominant primary motor cortex. A blinded rater assessed motor function using the Jebsen Taylor Hand Function Test. For the non-dominant hand, active tDCS was able to improve motor function significantly-there was a significant interaction between time and condition of stimulation (p = 0.003). Post hoc tests showed a significant enhancement of JTT performance after 1 mA anodal tDCS of M1 (mean improvement of 9.41%, p = 0.0004), but not after sham tDCS (mean improvement of 1.3%, p = 0.84). For the dominant hand, however, neither active nor sham tDCS resulted in a significant change in motor performance. Our findings show that anodal tDCS of the non-dominant primary motor cortex results in motor function enhancement and thus confirm and extend the notion that tDCS can change behavior. We speculate that the under-use of the non-dominant hand with its associated consequences in cortical plasticity might be one of the reasons to explain motor performance enhancement in the non-dominant hand only.

Authors+Show Affiliations

Department of Experimental Psychology, University of Sao Paulo, Brazil. boggio@usp.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16808997

Citation

Boggio, Paulo S., et al. "Enhancement of Non-dominant Hand Motor Function By Anodal Transcranial Direct Current Stimulation." Neuroscience Letters, vol. 404, no. 1-2, 2006, pp. 232-6.
Boggio PS, Castro LO, Savagim EA, et al. Enhancement of non-dominant hand motor function by anodal transcranial direct current stimulation. Neurosci Lett. 2006;404(1-2):232-6.
Boggio, P. S., Castro, L. O., Savagim, E. A., Braite, R., Cruz, V. C., Rocha, R. R., ... Fregni, F. (2006). Enhancement of non-dominant hand motor function by anodal transcranial direct current stimulation. Neuroscience Letters, 404(1-2), pp. 232-6.
Boggio PS, et al. Enhancement of Non-dominant Hand Motor Function By Anodal Transcranial Direct Current Stimulation. Neurosci Lett. 2006 Aug 14;404(1-2):232-6. PubMed PMID: 16808997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhancement of non-dominant hand motor function by anodal transcranial direct current stimulation. AU - Boggio,Paulo S, AU - Castro,Letícia O, AU - Savagim,Edna A, AU - Braite,Renata, AU - Cruz,Viviane C, AU - Rocha,Renata R, AU - Rigonatti,Sergio P, AU - Silva,Maria T A, AU - Fregni,Felipe, Y1 - 2006/06/30/ PY - 2006/02/17/received PY - 2006/04/18/revised PY - 2006/05/29/accepted PY - 2006/7/1/pubmed PY - 2006/9/19/medline PY - 2006/7/1/entrez SP - 232 EP - 6 JF - Neuroscience letters JO - Neurosci. Lett. VL - 404 IS - 1-2 N2 - Transcranial direct current stimulation (tDCS) is a non-invasive powerful method to modulate brain activity. It can enhance motor learning and working memory in healthy subjects. To investigate the effects of anodal tDCS (1 mA, 20 min) of the dominant and non-dominant primary motor cortex (M1) on hand motor performance in healthy right-handed volunteers, healthy subjects underwent one session of both sham and active anodal stimulation of the non-dominant or dominant primary motor cortex. A blinded rater assessed motor function using the Jebsen Taylor Hand Function Test. For the non-dominant hand, active tDCS was able to improve motor function significantly-there was a significant interaction between time and condition of stimulation (p = 0.003). Post hoc tests showed a significant enhancement of JTT performance after 1 mA anodal tDCS of M1 (mean improvement of 9.41%, p = 0.0004), but not after sham tDCS (mean improvement of 1.3%, p = 0.84). For the dominant hand, however, neither active nor sham tDCS resulted in a significant change in motor performance. Our findings show that anodal tDCS of the non-dominant primary motor cortex results in motor function enhancement and thus confirm and extend the notion that tDCS can change behavior. We speculate that the under-use of the non-dominant hand with its associated consequences in cortical plasticity might be one of the reasons to explain motor performance enhancement in the non-dominant hand only. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/16808997/Enhancement_of_non_dominant_hand_motor_function_by_anodal_transcranial_direct_current_stimulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(06)00554-4 DB - PRIME DP - Unbound Medicine ER -