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Cannabinoids biology: the search for new therapeutic targets.
Mol Interv. 2006 Jun; 6(3):149-61.MI

Abstract

Cannabinoids, in the form of marijuana plant extracts, have been used for thousands of years for a wide variety of medical conditions, ranging from general malaise and mood disorders to more specific ailments, such as pain, nausea, and muscle spasms. The discovery of tetrahydrocannabinol, the active principal in marijuana, and the identification and cloning of two cannabinoid receptors (i.e., CB1 and CB2) has subsequently led to biomedical appreciation for a family of endocannabinoid lipid transmitters. The biosynthesis and catabolism of the endocannabinoids and growing knowledge of their broad physiological roles are providing insight into potentially novel therapeutic targets. Compounds directed at one or more of these targets may allow for cannabinoid-based therapeutics with limited side effects and abuse liability.

Authors+Show Affiliations

Eli Lilly and Co., Neuroscience Division, Indianapolis, IN 46285, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16809476

Citation

Felder, Christian C., et al. "Cannabinoids Biology: the Search for New Therapeutic Targets." Molecular Interventions, vol. 6, no. 3, 2006, pp. 149-61.
Felder CC, Dickason-Chesterfield AK, Moore SA. Cannabinoids biology: the search for new therapeutic targets. Mol Interv. 2006;6(3):149-61.
Felder, C. C., Dickason-Chesterfield, A. K., & Moore, S. A. (2006). Cannabinoids biology: the search for new therapeutic targets. Molecular Interventions, 6(3), 149-61.
Felder CC, Dickason-Chesterfield AK, Moore SA. Cannabinoids Biology: the Search for New Therapeutic Targets. Mol Interv. 2006;6(3):149-61. PubMed PMID: 16809476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabinoids biology: the search for new therapeutic targets. AU - Felder,Christian C, AU - Dickason-Chesterfield,Amy K, AU - Moore,Steven A, PY - 2006/7/1/pubmed PY - 2007/6/23/medline PY - 2006/7/1/entrez SP - 149 EP - 61 JF - Molecular interventions JO - Mol. Interv. VL - 6 IS - 3 N2 - Cannabinoids, in the form of marijuana plant extracts, have been used for thousands of years for a wide variety of medical conditions, ranging from general malaise and mood disorders to more specific ailments, such as pain, nausea, and muscle spasms. The discovery of tetrahydrocannabinol, the active principal in marijuana, and the identification and cloning of two cannabinoid receptors (i.e., CB1 and CB2) has subsequently led to biomedical appreciation for a family of endocannabinoid lipid transmitters. The biosynthesis and catabolism of the endocannabinoids and growing knowledge of their broad physiological roles are providing insight into potentially novel therapeutic targets. Compounds directed at one or more of these targets may allow for cannabinoid-based therapeutics with limited side effects and abuse liability. SN - 1534-0384 UR - https://www.unboundmedicine.com/medline/citation/16809476/Cannabinoids_biology:_the_search_for_new_therapeutic_targets_ L2 - https://www.lens.org/lens/search?q=citation_id:16809476 DB - PRIME DP - Unbound Medicine ER -