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Markers of inflammation are inversely related to physical activity and fitness in sedentary men with treated hypertension.
Am J Hypertens. 2006 Jul; 19(7):669-75; discussion 676-7.AJ

Abstract

BACKGROUND

Physical inactivity is an important risk factor for atherosclerotic disease. We studied the relationship between physical activity and physical fitness and soluble markers of atherosclerotic activity in men with drug-treated hypertension.

METHODS

The participants (n = 177, 40 to 74 years of age), who were randomly recruited from the Hypertension High Risk Management Trial (HYRIM), were overweight and had sedentary lifestyles. The inflammatory markers high-sensitivity C-reactive protein (hs-CRP), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (SICAM-1) and soluble E-selectin (sE-selectin) and the hemostatic markers soluble thrombomodulin (sTM), von Willebrand factor (vWf), and tissue plasminogen activator antigen (tPAag) were measured. Physical activity was measured by use of a questionnaire. Time to exhaustion in a bicycle test was used as an expression of physical fitness.

RESULTS

The hs-CRP showed a significant inverse relationship with physical fitness independent of major cardiovascular risk factors (P = .017) but was not related to physical activity. The sE-selectin was significantly related to physical activity, although only when other factors were taken into account (P = .033), and it had no significant association with physical fitness. In addition there were strong associations between hs-CRP and sICAM-1 and the Framingham Coronary Heart Disease risk score (P < .001).

CONCLUSIONS

The observed inverse relations between physical fitness and hs-CRP and between level of physical activity and sE-selectin in drug-treated, hypertensive sedentary men indicates a beneficial effect of good fitness status as well as activity of low intensity on vessel wall inflammation.

Authors+Show Affiliations

Medical Division, Ullevål University Hospital, Kirkeveien, Oslo, Norway. anne@hjelstuen.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16814119

Citation

Hjelstuen, Anne, et al. "Markers of Inflammation Are Inversely Related to Physical Activity and Fitness in Sedentary Men With Treated Hypertension." American Journal of Hypertension, vol. 19, no. 7, 2006, pp. 669-75; discussion 676-7.
Hjelstuen A, Anderssen SA, Holme I, et al. Markers of inflammation are inversely related to physical activity and fitness in sedentary men with treated hypertension. Am J Hypertens. 2006;19(7):669-75; discussion 676-7.
Hjelstuen, A., Anderssen, S. A., Holme, I., Seljeflot, I., & Klemsdal, T. O. (2006). Markers of inflammation are inversely related to physical activity and fitness in sedentary men with treated hypertension. American Journal of Hypertension, 19(7), 669-75; discussion 676-7.
Hjelstuen A, et al. Markers of Inflammation Are Inversely Related to Physical Activity and Fitness in Sedentary Men With Treated Hypertension. Am J Hypertens. 2006;19(7):669-75; discussion 676-7. PubMed PMID: 16814119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Markers of inflammation are inversely related to physical activity and fitness in sedentary men with treated hypertension. AU - Hjelstuen,Anne, AU - Anderssen,Sigmund A, AU - Holme,Ingar, AU - Seljeflot,Ingebørg, AU - Klemsdal,Tor Ole, PY - 2005/05/23/received PY - 2005/11/01/revised PY - 2005/11/01/accepted PY - 2006/7/4/pubmed PY - 2006/11/15/medline PY - 2006/7/4/entrez SP - 669-75; discussion 676-7 JF - American journal of hypertension JO - Am J Hypertens VL - 19 IS - 7 N2 - BACKGROUND: Physical inactivity is an important risk factor for atherosclerotic disease. We studied the relationship between physical activity and physical fitness and soluble markers of atherosclerotic activity in men with drug-treated hypertension. METHODS: The participants (n = 177, 40 to 74 years of age), who were randomly recruited from the Hypertension High Risk Management Trial (HYRIM), were overweight and had sedentary lifestyles. The inflammatory markers high-sensitivity C-reactive protein (hs-CRP), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (SICAM-1) and soluble E-selectin (sE-selectin) and the hemostatic markers soluble thrombomodulin (sTM), von Willebrand factor (vWf), and tissue plasminogen activator antigen (tPAag) were measured. Physical activity was measured by use of a questionnaire. Time to exhaustion in a bicycle test was used as an expression of physical fitness. RESULTS: The hs-CRP showed a significant inverse relationship with physical fitness independent of major cardiovascular risk factors (P = .017) but was not related to physical activity. The sE-selectin was significantly related to physical activity, although only when other factors were taken into account (P = .033), and it had no significant association with physical fitness. In addition there were strong associations between hs-CRP and sICAM-1 and the Framingham Coronary Heart Disease risk score (P < .001). CONCLUSIONS: The observed inverse relations between physical fitness and hs-CRP and between level of physical activity and sE-selectin in drug-treated, hypertensive sedentary men indicates a beneficial effect of good fitness status as well as activity of low intensity on vessel wall inflammation. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/16814119/Markers_of_inflammation_are_inversely_related_to_physical_activity_and_fitness_in_sedentary_men_with_treated_hypertension_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2005.11.012 DB - PRIME DP - Unbound Medicine ER -