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Effect of maternal exposure to nicotine in the rat on level and binding of somatostatin in brain of developing offspring.
Neuropharmacology. 1991 Jun; 30(6):579-84.N

Abstract

The effect of maternal exposure to nicotine on the level of somatostatin and specific binding in frontoparietal cortex and hippocampus of developing offspring was investigated. Sprague-Dawley rats were injected subcutaneously, throughout the pregnancy and the nursing period, with either: 3 mg/kg nicotine base or saline vehicle. In the offspring of control rats, the level of somatostatin-like immunoreactivity peaked at day 10 in the frontoparietal cortex, whereas the level of immunoreactivity in the hippocampus was the highest on day 30. Maternal exposure to nicotine caused enhanced levels of immunoreactivity in the frontoparietal cortex, on the day of birth and in the hippocampus, up to day 10. The maximum specific binding of somatostatin to the receptors in membranes from the frontoparietal cortex, peaked at 10 days of age in the offspring of control rats. The number of somatostatin receptors in cortical (but not in hippocampal) membranes was significantly decreased in the 0- to 10-day-old offspring of the nicotine-treated rats. Despite transient alterations in the number of somatostatin receptors, the affinity of the sites for somatostatin was consistently unchanged. The levels of somatostatin-like immunoreactivity and the number of somatostatin receptors in the frontoparietal cortex and hippocampus was comparable in the 30-day-old offspring of the control and nicotine-treated rats.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, Medical School, University of Alcalá, Madrid, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1681443

Citation

Barrios, V, et al. "Effect of Maternal Exposure to Nicotine in the Rat On Level and Binding of Somatostatin in Brain of Developing Offspring." Neuropharmacology, vol. 30, no. 6, 1991, pp. 579-84.
Barrios V, Rodríguez-Sánchez MN, Arilla E. Effect of maternal exposure to nicotine in the rat on level and binding of somatostatin in brain of developing offspring. Neuropharmacology. 1991;30(6):579-84.
Barrios, V., Rodríguez-Sánchez, M. N., & Arilla, E. (1991). Effect of maternal exposure to nicotine in the rat on level and binding of somatostatin in brain of developing offspring. Neuropharmacology, 30(6), 579-84.
Barrios V, Rodríguez-Sánchez MN, Arilla E. Effect of Maternal Exposure to Nicotine in the Rat On Level and Binding of Somatostatin in Brain of Developing Offspring. Neuropharmacology. 1991;30(6):579-84. PubMed PMID: 1681443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of maternal exposure to nicotine in the rat on level and binding of somatostatin in brain of developing offspring. AU - Barrios,V, AU - Rodríguez-Sánchez,M N, AU - Arilla,E, PY - 1991/6/1/pubmed PY - 1991/6/1/medline PY - 1991/6/1/entrez SP - 579 EP - 84 JF - Neuropharmacology JO - Neuropharmacology VL - 30 IS - 6 N2 - The effect of maternal exposure to nicotine on the level of somatostatin and specific binding in frontoparietal cortex and hippocampus of developing offspring was investigated. Sprague-Dawley rats were injected subcutaneously, throughout the pregnancy and the nursing period, with either: 3 mg/kg nicotine base or saline vehicle. In the offspring of control rats, the level of somatostatin-like immunoreactivity peaked at day 10 in the frontoparietal cortex, whereas the level of immunoreactivity in the hippocampus was the highest on day 30. Maternal exposure to nicotine caused enhanced levels of immunoreactivity in the frontoparietal cortex, on the day of birth and in the hippocampus, up to day 10. The maximum specific binding of somatostatin to the receptors in membranes from the frontoparietal cortex, peaked at 10 days of age in the offspring of control rats. The number of somatostatin receptors in cortical (but not in hippocampal) membranes was significantly decreased in the 0- to 10-day-old offspring of the nicotine-treated rats. Despite transient alterations in the number of somatostatin receptors, the affinity of the sites for somatostatin was consistently unchanged. The levels of somatostatin-like immunoreactivity and the number of somatostatin receptors in the frontoparietal cortex and hippocampus was comparable in the 30-day-old offspring of the control and nicotine-treated rats. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/1681443/Effect_of_maternal_exposure_to_nicotine_in_the_rat_on_level_and_binding_of_somatostatin_in_brain_of_developing_offspring_ DB - PRIME DP - Unbound Medicine ER -