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Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans.
Psychoneuroendocrinology. 2006 Sep; 31(8):915-23.P

Abstract

Ghrelin is an endogenous ligand of the growth hormone (GH) secretagogue (GHS) receptor. It is hypothesised to play a key role in energy balance stimulating food intake and body weight. Besides GH-releasing hormone (GHRH) and somatostatin, it is thought to be a regulating factor of GH release. Ghrelin also appears to be involved in sleep regulation. We showed recently that ghrelin promotes slow-wave sleep and the nocturnal release of GH, cortisol and prolactin in humans. Similarly, promotion of non-rapid-eye-movement (NREM) sleep was reported in mice after systemic ghrelin. If ghrelin is a factor that induces and/or maintains sleep, it should be enhanced after a period of sleep deprivation (SD). To clarify this issue, nocturnal ghrelin, GH, ACTH and cortisol plasma concentrations were determined and simultaneously sleep electroencephalogram (EEG) was recorded (2300-0700 h) during sleep before and after 1 night of total SD in 8 healthy subjects. Compared to baseline, ghrelin levels increased earlier by a non-significant trend, already before the beginning of recovery sleep. Further a non-significant trend occurred, suggesting higher ghrelin secretion in the first half of the night. The ghrelin maximum was found significantly earlier after SD than at baseline. GH secretion during the first half of the night and total night after SD were elevated. ACTH and cortisol were also elevated, which was most pronounced during the second half of the night. No effects of SD on the time of the maximum were found for GH, ACTH and cortisol. The increase in ACTH after SD is a novel finding. Whereas the effects of SD on ghrelin levels were relatively weak, our findings are in line with the hypothesis that ghrelin is a sleep-promoting factor in humans. Ghrelin may be involved in sleep promotion after SD.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Munich, Germany. schuessler@mpipsykl.mpg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16814473

Citation

Schüssler, P, et al. "Nocturnal Ghrelin, ACTH, GH and Cortisol Secretion After Sleep Deprivation in Humans." Psychoneuroendocrinology, vol. 31, no. 8, 2006, pp. 915-23.
Schüssler P, Uhr M, Ising M, et al. Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans. Psychoneuroendocrinology. 2006;31(8):915-23.
Schüssler, P., Uhr, M., Ising, M., Weikel, J. C., Schmid, D. A., Held, K., Mathias, S., & Steiger, A. (2006). Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans. Psychoneuroendocrinology, 31(8), 915-23.
Schüssler P, et al. Nocturnal Ghrelin, ACTH, GH and Cortisol Secretion After Sleep Deprivation in Humans. Psychoneuroendocrinology. 2006;31(8):915-23. PubMed PMID: 16814473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans. AU - Schüssler,P, AU - Uhr,M, AU - Ising,M, AU - Weikel,J C, AU - Schmid,D A, AU - Held,K, AU - Mathias,S, AU - Steiger,A, Y1 - 2006/06/30/ PY - 2005/11/11/received PY - 2006/05/01/revised PY - 2006/05/01/accepted PY - 2006/7/4/pubmed PY - 2006/10/13/medline PY - 2006/7/4/entrez SP - 915 EP - 23 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 31 IS - 8 N2 - Ghrelin is an endogenous ligand of the growth hormone (GH) secretagogue (GHS) receptor. It is hypothesised to play a key role in energy balance stimulating food intake and body weight. Besides GH-releasing hormone (GHRH) and somatostatin, it is thought to be a regulating factor of GH release. Ghrelin also appears to be involved in sleep regulation. We showed recently that ghrelin promotes slow-wave sleep and the nocturnal release of GH, cortisol and prolactin in humans. Similarly, promotion of non-rapid-eye-movement (NREM) sleep was reported in mice after systemic ghrelin. If ghrelin is a factor that induces and/or maintains sleep, it should be enhanced after a period of sleep deprivation (SD). To clarify this issue, nocturnal ghrelin, GH, ACTH and cortisol plasma concentrations were determined and simultaneously sleep electroencephalogram (EEG) was recorded (2300-0700 h) during sleep before and after 1 night of total SD in 8 healthy subjects. Compared to baseline, ghrelin levels increased earlier by a non-significant trend, already before the beginning of recovery sleep. Further a non-significant trend occurred, suggesting higher ghrelin secretion in the first half of the night. The ghrelin maximum was found significantly earlier after SD than at baseline. GH secretion during the first half of the night and total night after SD were elevated. ACTH and cortisol were also elevated, which was most pronounced during the second half of the night. No effects of SD on the time of the maximum were found for GH, ACTH and cortisol. The increase in ACTH after SD is a novel finding. Whereas the effects of SD on ghrelin levels were relatively weak, our findings are in line with the hypothesis that ghrelin is a sleep-promoting factor in humans. Ghrelin may be involved in sleep promotion after SD. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/16814473/Nocturnal_ghrelin_ACTH_GH_and_cortisol_secretion_after_sleep_deprivation_in_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(06)00088-6 DB - PRIME DP - Unbound Medicine ER -