Tags

Type your tag names separated by a space and hit enter

pH-independent pulsatile drug delivery system based on hard gelatin capsules and coated with aqueous dispersion Aquacoat ECD.
Eur J Pharm Biopharm. 2006 Oct; 64(2):173-9.EJ

Abstract

The objective of this study was to develop a rupturable, capsule-based pulsatile drug delivery system with pH-independent properties prepared using aqueous coating. The drug release is induced by rupturing of the top-coating, resulting by expanding of swellable layer upon water penetration through the top-coating. Croscarmellose sodium (AcDiSol) is a preferable superdisintegrant compared to low substituted hydroxypropylcellulose (L-HPC) and sodium starch glycolate (Explotab), because of controlled lag time, followed by a quick and complete drug release. However, due to its anionic character, AcDiSol showed pH-dependent swelling characteristics (pH 7.4 > 0.1N HCl) resulting in a pH-dependent lag time. The pH dependency could be eliminated by the addition of fumaric acid to the swelling layer, which allowed to keep an acidic micro-environment. Formation of the rupturable top-coating was successfully performed using an aqueous dispersion of ethylcellulose (Aquacoat) ECD), whereby sufficient drying during the coating was needed to avoid swelling of the AcDiSol layer. A higher coating level was required, when aqueous dispersion was used, compared to organic coatings. However, an advantageous aspect of the aqueous coating was the lower sensitivity of the lag time to a deviation in the coating level.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Mohamad A
College of Pharmacy, Department of Pharmaceutical Technology, Berlin, Germany.
Dashevsky A
No affiliation info available

MeSH

CapsulesCelluloseDesiccationDrug CompoundingDrug Delivery SystemsDrug StabilityFumaratesGelatinHumidityHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsPulsatile FlowSolubilitySurface PropertiesWater

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16814532

Citation

Mohamad, Ahmad, and Andrei Dashevsky. "PH-independent Pulsatile Drug Delivery System Based On Hard Gelatin Capsules and Coated With Aqueous Dispersion Aquacoat ECD." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 64, no. 2, 2006, pp. 173-9.
Mohamad A, Dashevsky A. PH-independent pulsatile drug delivery system based on hard gelatin capsules and coated with aqueous dispersion Aquacoat ECD. Eur J Pharm Biopharm. 2006;64(2):173-9.
Mohamad, A., & Dashevsky, A. (2006). PH-independent pulsatile drug delivery system based on hard gelatin capsules and coated with aqueous dispersion Aquacoat ECD. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 64(2), 173-9.
Mohamad A, Dashevsky A. PH-independent Pulsatile Drug Delivery System Based On Hard Gelatin Capsules and Coated With Aqueous Dispersion Aquacoat ECD. Eur J Pharm Biopharm. 2006;64(2):173-9. PubMed PMID: 16814532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - pH-independent pulsatile drug delivery system based on hard gelatin capsules and coated with aqueous dispersion Aquacoat ECD. AU - Mohamad,Ahmad, AU - Dashevsky,Andrei, Y1 - 2006/05/16/ PY - 2006/01/12/received PY - 2006/04/12/revised PY - 2006/04/26/accepted PY - 2006/7/4/pubmed PY - 2007/2/10/medline PY - 2006/7/4/entrez SP - 173 EP - 9 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 64 IS - 2 N2 - The objective of this study was to develop a rupturable, capsule-based pulsatile drug delivery system with pH-independent properties prepared using aqueous coating. The drug release is induced by rupturing of the top-coating, resulting by expanding of swellable layer upon water penetration through the top-coating. Croscarmellose sodium (AcDiSol) is a preferable superdisintegrant compared to low substituted hydroxypropylcellulose (L-HPC) and sodium starch glycolate (Explotab), because of controlled lag time, followed by a quick and complete drug release. However, due to its anionic character, AcDiSol showed pH-dependent swelling characteristics (pH 7.4 > 0.1N HCl) resulting in a pH-dependent lag time. The pH dependency could be eliminated by the addition of fumaric acid to the swelling layer, which allowed to keep an acidic micro-environment. Formation of the rupturable top-coating was successfully performed using an aqueous dispersion of ethylcellulose (Aquacoat) ECD), whereby sufficient drying during the coating was needed to avoid swelling of the AcDiSol layer. A higher coating level was required, when aqueous dispersion was used, compared to organic coatings. However, an advantageous aspect of the aqueous coating was the lower sensitivity of the lag time to a deviation in the coating level. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/16814532/pH_independent_pulsatile_drug_delivery_system_based_on_hard_gelatin_capsules_and_coated_with_aqueous_dispersion_Aquacoat_ECD_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(06)00086-5 DB - PRIME DP - Unbound Medicine ER -