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Post-tympanostomy tube otorrhea: a meta-analysis.
Otolaryngol Head Neck Surg 2006; 135(1):8-11OH

Abstract

INTRODUCTION

Post-tympanostomy tube otorrhea is the most common complication of tympanostomy tube placement. The incidence of this problem varies from 3.4% to 74%. Trials that study post-tympanostomy tube otorrhea may involve valid randomization "by patient" or "by ear." In an attempt to define "best practice," we conduct a meta-analysis to quantify the benefit of using topical prophylactic antibiotic drops in the postoperative period. We then compare our findings with previous results found in the literature.

METHODS

We selected randomized studies for which antibiotic drops had been used for at least 48 hours after tympanostomy tube insertion. Nine studies, 3 "by ear" and 6 "by patient," met our inclusion criteria. The odds ratio and 95% confidence intervals were calculated for each to conduct the meta-analysis.

RESULTS

Overall, prophylaxis appears to be effective at reducing the incidence of post-tympanostomy tube otorrhea. The odds ratios for all studies were less than 1.0. However, none of the 3 "by ear" studies and only 3 of the 6 "by patient" studies were statistically significant. The mean odds ratio was 52%, suggesting that prophylaxis may reduce the incidence of post-tympanostomy tube otorrhea by half.

CONCLUSION

This meta-analysis suggests that routine post-tympanostomy tube prophylaxis is beneficial, but this finding is dependent on selection criteria used.

EBM RATING

A-1a.

Authors+Show Affiliations

Department of Otolaryngology, University of Manitoba, GB421-820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

16815174

Citation

Hochman, Jordan, et al. "Post-tympanostomy Tube Otorrhea: a Meta-analysis." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 135, no. 1, 2006, pp. 8-11.
Hochman J, Blakley B, Abdoh A, et al. Post-tympanostomy tube otorrhea: a meta-analysis. Otolaryngol Head Neck Surg. 2006;135(1):8-11.
Hochman, J., Blakley, B., Abdoh, A., & Aleid, H. (2006). Post-tympanostomy tube otorrhea: a meta-analysis. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 135(1), pp. 8-11.
Hochman J, et al. Post-tympanostomy Tube Otorrhea: a Meta-analysis. Otolaryngol Head Neck Surg. 2006;135(1):8-11. PubMed PMID: 16815174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-tympanostomy tube otorrhea: a meta-analysis. AU - Hochman,Jordan, AU - Blakley,Brian, AU - Abdoh,Ahmed, AU - Aleid,Hazim, PY - 2005/12/13/received PY - 2006/02/01/accepted PY - 2006/7/4/pubmed PY - 2006/8/4/medline PY - 2006/7/4/entrez SP - 8 EP - 11 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 135 IS - 1 N2 - INTRODUCTION: Post-tympanostomy tube otorrhea is the most common complication of tympanostomy tube placement. The incidence of this problem varies from 3.4% to 74%. Trials that study post-tympanostomy tube otorrhea may involve valid randomization "by patient" or "by ear." In an attempt to define "best practice," we conduct a meta-analysis to quantify the benefit of using topical prophylactic antibiotic drops in the postoperative period. We then compare our findings with previous results found in the literature. METHODS: We selected randomized studies for which antibiotic drops had been used for at least 48 hours after tympanostomy tube insertion. Nine studies, 3 "by ear" and 6 "by patient," met our inclusion criteria. The odds ratio and 95% confidence intervals were calculated for each to conduct the meta-analysis. RESULTS: Overall, prophylaxis appears to be effective at reducing the incidence of post-tympanostomy tube otorrhea. The odds ratios for all studies were less than 1.0. However, none of the 3 "by ear" studies and only 3 of the 6 "by patient" studies were statistically significant. The mean odds ratio was 52%, suggesting that prophylaxis may reduce the incidence of post-tympanostomy tube otorrhea by half. CONCLUSION: This meta-analysis suggests that routine post-tympanostomy tube prophylaxis is beneficial, but this finding is dependent on selection criteria used. EBM RATING: A-1a. SN - 0194-5998 UR - https://www.unboundmedicine.com/medline/citation/16815174/Post_tympanostomy_tube_otorrhea:_a_meta_analysis_ L2 - http://journals.sagepub.com/doi/full/10.1016/j.otohns.2006.02.019?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -