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Fructose-enriched diet modifies antioxidant status and lipid metabolism in spontaneously hypertensive rats.
Nutrition 2006 Jul-Aug; 22(7-8):758-66N

Abstract

OBJECTIVE

High-fructose consumption in industrial countries has been shown to induce metabolic abnormalities or syndrome X. Changes in antioxidant defense are unknown in hypertension associated with metabolic disorders induced by high-fructose feeding.

METHODS

Twenty spontaneously hypertensive rats were assigned to one of two groups; one received a fructose-enriched diet (60% fructose) and the other a starch diet. After a 13-wk diet period, total antioxidant status was assessed in the blood and liver by monitoring the rate of free radical-induced red blood cell hemolysis. Antioxidants (enzymes and vitamins) were determined in blood and liver. Gene expression of antioxidant enzymes (copper/zinc superoxide dismutase and glutathione peroxidase) were also investigated in hepatic tissue.

RESULTS

Fructose-fed rats showed blood pressure values similar to that of control rats but had increased glycemia and insulinemia. The antioxidant capacity in the blood of the fructose-fed group represented by copper/zinc superoxide dismutase and glutathione peroxidase activities and ascorbic acid was lower. However, the fructose diet enhanced the total antioxidant capacity of liver correlated with increased antioxidant enzyme activities and retinol concentrations. Gutathione peroxidase mRNA expression was decreased in livers of spontaneously hypertensive rats fed the fructose diet.

CONCLUSION

Fructose feeding negatively affects antioxidant capacity in the blood of hypertensive rats but improves this capacity in the liver.

Authors+Show Affiliations

UPRES Lipides Nutrition EA 2422, Faculté des Sciences Gabriel, Université de Bourgogne, Dijon, France. aurelie.girard@u-bourgogne.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16815490

Citation

Girard, Aurélie, et al. "Fructose-enriched Diet Modifies Antioxidant Status and Lipid Metabolism in Spontaneously Hypertensive Rats." Nutrition (Burbank, Los Angeles County, Calif.), vol. 22, no. 7-8, 2006, pp. 758-66.
Girard A, Madani S, Boukortt F, et al. Fructose-enriched diet modifies antioxidant status and lipid metabolism in spontaneously hypertensive rats. Nutrition. 2006;22(7-8):758-66.
Girard, A., Madani, S., Boukortt, F., Cherkaoui-Malki, M., Belleville, J., & Prost, J. (2006). Fructose-enriched diet modifies antioxidant status and lipid metabolism in spontaneously hypertensive rats. Nutrition (Burbank, Los Angeles County, Calif.), 22(7-8), pp. 758-66.
Girard A, et al. Fructose-enriched Diet Modifies Antioxidant Status and Lipid Metabolism in Spontaneously Hypertensive Rats. Nutrition. 2006;22(7-8):758-66. PubMed PMID: 16815490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fructose-enriched diet modifies antioxidant status and lipid metabolism in spontaneously hypertensive rats. AU - Girard,Aurélie, AU - Madani,Sihem, AU - Boukortt,Farida, AU - Cherkaoui-Malki,Mustapha, AU - Belleville,Jacques, AU - Prost,Josiane, PY - 2005/12/22/received PY - 2006/03/22/revised PY - 2006/05/10/accepted PY - 2006/7/4/pubmed PY - 2006/12/9/medline PY - 2006/7/4/entrez SP - 758 EP - 66 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 22 IS - 7-8 N2 - OBJECTIVE: High-fructose consumption in industrial countries has been shown to induce metabolic abnormalities or syndrome X. Changes in antioxidant defense are unknown in hypertension associated with metabolic disorders induced by high-fructose feeding. METHODS: Twenty spontaneously hypertensive rats were assigned to one of two groups; one received a fructose-enriched diet (60% fructose) and the other a starch diet. After a 13-wk diet period, total antioxidant status was assessed in the blood and liver by monitoring the rate of free radical-induced red blood cell hemolysis. Antioxidants (enzymes and vitamins) were determined in blood and liver. Gene expression of antioxidant enzymes (copper/zinc superoxide dismutase and glutathione peroxidase) were also investigated in hepatic tissue. RESULTS: Fructose-fed rats showed blood pressure values similar to that of control rats but had increased glycemia and insulinemia. The antioxidant capacity in the blood of the fructose-fed group represented by copper/zinc superoxide dismutase and glutathione peroxidase activities and ascorbic acid was lower. However, the fructose diet enhanced the total antioxidant capacity of liver correlated with increased antioxidant enzyme activities and retinol concentrations. Gutathione peroxidase mRNA expression was decreased in livers of spontaneously hypertensive rats fed the fructose diet. CONCLUSION: Fructose feeding negatively affects antioxidant capacity in the blood of hypertensive rats but improves this capacity in the liver. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/16815490/Fructose_enriched_diet_modifies_antioxidant_status_and_lipid_metabolism_in_spontaneously_hypertensive_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(06)00226-7 DB - PRIME DP - Unbound Medicine ER -