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Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania.
Am J Psychiatry. 2006 Jul; 163(7):1282-4.AJ

Abstract

OBJECTIVE

Problems with inhibiting certain pathological behaviors are integral to obsessive-compulsive disorder (OCD), trichotillomania, and other putative obsessive-compulsive spectrum disorders. The authors assessed and compared motor inhibition and cognitive flexibility in OCD and trichotillomania for the first time, to their knowledge.

METHOD

The Stop-Signal Task and the Intradimensiona/Extradimensional Shift Task were administered to 20 patients with OCD, 17 patients with trichotillomania, and 20 healthy comparison subjects.

RESULTS

Both OCD and trichotillomania showed impaired inhibition of motor responses. For trichotillomania, the deficit was worse than for OCD, and the degree of the deficit correlated significantly with symptom severity. Only patients with OCD showed deficits in cognitive flexibility.

CONCLUSIONS

Impaired inhibition of motor responses (impulsivity) was found in OCD and trichotillomania, whereas cognitive inflexibility (thought to contribute to compulsivity) was limited to OCD. This assessment will advance the characterization and classification of obsessive-compulsive spectrum disorders and aid the development of novel treatments.

Authors+Show Affiliations

Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Box 189, Cambridge, UK. src33@cam.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16816237

Citation

Chamberlain, Samuel R., et al. "Motor Inhibition and Cognitive Flexibility in Obsessive-compulsive Disorder and Trichotillomania." The American Journal of Psychiatry, vol. 163, no. 7, 2006, pp. 1282-4.
Chamberlain SR, Fineberg NA, Blackwell AD, et al. Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. Am J Psychiatry. 2006;163(7):1282-4.
Chamberlain, S. R., Fineberg, N. A., Blackwell, A. D., Robbins, T. W., & Sahakian, B. J. (2006). Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. The American Journal of Psychiatry, 163(7), 1282-4.
Chamberlain SR, et al. Motor Inhibition and Cognitive Flexibility in Obsessive-compulsive Disorder and Trichotillomania. Am J Psychiatry. 2006;163(7):1282-4. PubMed PMID: 16816237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. AU - Chamberlain,Samuel R, AU - Fineberg,Naomi A, AU - Blackwell,Andrew D, AU - Robbins,Trevor W, AU - Sahakian,Barbara J, PY - 2006/7/4/pubmed PY - 2006/8/11/medline PY - 2006/7/4/entrez SP - 1282 EP - 4 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 163 IS - 7 N2 - OBJECTIVE: Problems with inhibiting certain pathological behaviors are integral to obsessive-compulsive disorder (OCD), trichotillomania, and other putative obsessive-compulsive spectrum disorders. The authors assessed and compared motor inhibition and cognitive flexibility in OCD and trichotillomania for the first time, to their knowledge. METHOD: The Stop-Signal Task and the Intradimensiona/Extradimensional Shift Task were administered to 20 patients with OCD, 17 patients with trichotillomania, and 20 healthy comparison subjects. RESULTS: Both OCD and trichotillomania showed impaired inhibition of motor responses. For trichotillomania, the deficit was worse than for OCD, and the degree of the deficit correlated significantly with symptom severity. Only patients with OCD showed deficits in cognitive flexibility. CONCLUSIONS: Impaired inhibition of motor responses (impulsivity) was found in OCD and trichotillomania, whereas cognitive inflexibility (thought to contribute to compulsivity) was limited to OCD. This assessment will advance the characterization and classification of obsessive-compulsive spectrum disorders and aid the development of novel treatments. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/16816237/Motor_inhibition_and_cognitive_flexibility_in_obsessive_compulsive_disorder_and_trichotillomania_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.163.7.1282?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -