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Rapid vascular clearance of two strains of Junin virus in Calomys musculinus: selective macrophage clearance.
Acta Virol. 1991 Apr; 35(2):144-51.AV

Abstract

Clearance of Junin (JUN) virus strains with different virulence for Calomys musculinus (Cm) was followed using the Candid #1 virulent and CbaFHA 5069 attenuated strains. In addition, virulent virus albino mice (AM) were included as control host and Venezuelan equine encephalitis (VEE-VI) virus as control virus. The virus inoculum (Vo) and the blood samples (Vt) obtained at different times post-inoculation (p.i.) were titrated on Vero cells and the cleared plaque forming-units (PFU) were calculated as the log Vt/Vo. In Cm both JUN virus strains were cleared rapidly (within 5 min the Candid #1 strain and within 10 min the CbaFHA 5069 strain); meanwhile, VEE-VI virus could be recovered from blood until 30 min p. i. Furthermore, JUN and VEE-VI viruses showed the same behaviour in Am as in Cm. We conclude that the JUN virus strains of different virulence for Cm did not show differences in their clearance from the blood of these animals. Moreover, the rapid clearance observed was independent of the animal host and viral dose.

Authors+Show Affiliations

Instituto de Virologia, Universidad Nacional de Cordoba, Ciudad Universitaria, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1681712

Citation

Contigiani, M S., et al. "Rapid Vascular Clearance of Two Strains of Junin Virus in Calomys Musculinus: Selective Macrophage Clearance." Acta Virologica, vol. 35, no. 2, 1991, pp. 144-51.
Contigiani MS, Medeot SI, Diaz GE, et al. Rapid vascular clearance of two strains of Junin virus in Calomys musculinus: selective macrophage clearance. Acta Virol. 1991;35(2):144-51.
Contigiani, M. S., Medeot, S. I., Diaz, G. E., & Sabattini, M. S. (1991). Rapid vascular clearance of two strains of Junin virus in Calomys musculinus: selective macrophage clearance. Acta Virologica, 35(2), 144-51.
Contigiani MS, et al. Rapid Vascular Clearance of Two Strains of Junin Virus in Calomys Musculinus: Selective Macrophage Clearance. Acta Virol. 1991;35(2):144-51. PubMed PMID: 1681712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid vascular clearance of two strains of Junin virus in Calomys musculinus: selective macrophage clearance. AU - Contigiani,M S, AU - Medeot,S I, AU - Diaz,G E, AU - Sabattini,M S, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 144 EP - 51 JF - Acta virologica JO - Acta Virol VL - 35 IS - 2 N2 - Clearance of Junin (JUN) virus strains with different virulence for Calomys musculinus (Cm) was followed using the Candid #1 virulent and CbaFHA 5069 attenuated strains. In addition, virulent virus albino mice (AM) were included as control host and Venezuelan equine encephalitis (VEE-VI) virus as control virus. The virus inoculum (Vo) and the blood samples (Vt) obtained at different times post-inoculation (p.i.) were titrated on Vero cells and the cleared plaque forming-units (PFU) were calculated as the log Vt/Vo. In Cm both JUN virus strains were cleared rapidly (within 5 min the Candid #1 strain and within 10 min the CbaFHA 5069 strain); meanwhile, VEE-VI virus could be recovered from blood until 30 min p. i. Furthermore, JUN and VEE-VI viruses showed the same behaviour in Am as in Cm. We conclude that the JUN virus strains of different virulence for Cm did not show differences in their clearance from the blood of these animals. Moreover, the rapid clearance observed was independent of the animal host and viral dose. SN - 0001-723X UR - https://www.unboundmedicine.com/medline/citation/1681712/Rapid_vascular_clearance_of_two_strains_of_Junin_virus_in_Calomys_musculinus:_selective_macrophage_clearance_ DB - PRIME DP - Unbound Medicine ER -