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Autoimmune pathogenesis in dengue virus infection.
Viral Immunol. 2006 Summer; 19(2):127-32.VI

Abstract

The pathogenic mechanisms of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) caused by dengue virus (DV) infection remain unresolved. Patients with DHF/DSS are characterized by several manifestations, including severe thrombocytopenia, vascular leakage, and hepatomegaly. In addition to the effect of virus load and virus variation, abnormal immune responses of the host after DV infection may also account for the progression of DHF/DSS. Actually, viral autoimmunity is involved in the pathogenesis of numerous viral infections, such as human immunodeficiency virus, human hepatitis C virus, human cytomegalovirus, herpes simplex virus, Epstein- Barr virus, and DV. In this review, we discuss the implications of autoimmunity in dengue pathogenesis. Antibodies directed against DV nonstructural protein 1 (NS1) showed cross-reactivity with human platelets and endothelial cells, which lead to platelet and endothelial cell damage and inflammatory activation. Based on these findings, we hypothesize that anti-DV NS1 is involved in the pathogenesis of DF and DHF/DSS, and this may provide important information in dengue vaccine development.

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Authors+Show Affiliations

Lin CF
Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan.
Wan SW
No affiliation info available
Cheng HJ
No affiliation info available
Lei HY
No affiliation info available
Lin YS
No affiliation info available

MeSH

Antibodies, ViralAutoimmunityBlood PlateletsCross ReactionsDengueDengue VirusEndothelial CellsHumansSevere DengueViral Nonstructural Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16817755

Citation

Lin, Chiou-Feng, et al. "Autoimmune Pathogenesis in Dengue Virus Infection." Viral Immunology, vol. 19, no. 2, 2006, pp. 127-32.
Lin CF, Wan SW, Cheng HJ, et al. Autoimmune pathogenesis in dengue virus infection. Viral Immunol. 2006;19(2):127-32.
Lin, C. F., Wan, S. W., Cheng, H. J., Lei, H. Y., & Lin, Y. S. (2006). Autoimmune pathogenesis in dengue virus infection. Viral Immunology, 19(2), 127-32.
Lin CF, et al. Autoimmune Pathogenesis in Dengue Virus Infection. Viral Immunol. 2006;19(2):127-32. PubMed PMID: 16817755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoimmune pathogenesis in dengue virus infection. AU - Lin,Chiou-Feng, AU - Wan,Shu-Wen, AU - Cheng,Hsien-Jen, AU - Lei,Huan-Yao, AU - Lin,Yee-Shin, PY - 2006/7/5/pubmed PY - 2006/9/29/medline PY - 2006/7/5/entrez SP - 127 EP - 32 JF - Viral immunology JO - Viral Immunol VL - 19 IS - 2 N2 - The pathogenic mechanisms of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) caused by dengue virus (DV) infection remain unresolved. Patients with DHF/DSS are characterized by several manifestations, including severe thrombocytopenia, vascular leakage, and hepatomegaly. In addition to the effect of virus load and virus variation, abnormal immune responses of the host after DV infection may also account for the progression of DHF/DSS. Actually, viral autoimmunity is involved in the pathogenesis of numerous viral infections, such as human immunodeficiency virus, human hepatitis C virus, human cytomegalovirus, herpes simplex virus, Epstein- Barr virus, and DV. In this review, we discuss the implications of autoimmunity in dengue pathogenesis. Antibodies directed against DV nonstructural protein 1 (NS1) showed cross-reactivity with human platelets and endothelial cells, which lead to platelet and endothelial cell damage and inflammatory activation. Based on these findings, we hypothesize that anti-DV NS1 is involved in the pathogenesis of DF and DHF/DSS, and this may provide important information in dengue vaccine development. SN - 0882-8245 UR - https://www.unboundmedicine.com/medline/citation/16817755/Autoimmune_pathogenesis_in_dengue_virus_infection_ L2 - https://www.liebertpub.com/doi/10.1089/vim.2006.19.127?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -