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Measles virus-specific IgG4 antibody titer as a serologic marker of post-vaccinal immune response.
Viral Immunol. 2006 Summer; 19(2):335-9.VI

Abstract

In previous research, we concluded that measles virus specific IgG4 antibody titer could be used to differentiate between natural [IgG4 GMT 80 (95% CI, 33 to 191)] and vaccinal source of measles infection [IgG4 GMT 13 (95% CI, 7 to 26)]. The aim of this paper is to show that this new serologic marker (IgG4 measles antibody titer) can be applied to help interpret rare but well documented cases of measles Ig M-positive results in vaccinated individuals who, 1-2 months after vaccination, developed rash and fever and therefore do not meet the criteria for post-vaccinal measles infection. Six measles IgM-positive serum samples obtained from measles vaccinated individuals who developed rash/fever 1 to 2 months post-vaccination were studied by Immunofluorescence assay for the quantification of IgG4 measles specific antibody. IgG4 antibody titers from all these samples were between 1:10-1:20, consequently, the IgM positive results from the study cases could be ascribed to post-vaccinal immune response. Thus, measles virus specific IgG4 antibody titer could be used as a serologic marker of post-vaccinal immune response.

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Authors+Show Affiliations

Isa MB
Instituto de Virología Dr. J.M. Vanella, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gómez s/n, Ciudad Universitaria, Córdoba, Argentina.
Martínez LC
No affiliation info available
Ferreyra LJ
No affiliation info available
Giordano MO
No affiliation info available
Barril PA
No affiliation info available
Massachessi G
No affiliation info available
Nates SV
No affiliation info available

MeSH

Antibodies, ViralAntibody SpecificityBiomarkersExanthemaFeverHumansImmunoglobulin GImmunoglobulin MMeaslesMeasles VaccineMeasles virusVaccination

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16817776

Citation

Isa, María B., et al. "Measles Virus-specific IgG4 Antibody Titer as a Serologic Marker of Post-vaccinal Immune Response." Viral Immunology, vol. 19, no. 2, 2006, pp. 335-9.
Isa MB, Martínez LC, Ferreyra LJ, et al. Measles virus-specific IgG4 antibody titer as a serologic marker of post-vaccinal immune response. Viral Immunol. 2006;19(2):335-9.
Isa, M. B., Martínez, L. C., Ferreyra, L. J., Giordano, M. O., Barril, P. A., Massachessi, G., & Nates, S. V. (2006). Measles virus-specific IgG4 antibody titer as a serologic marker of post-vaccinal immune response. Viral Immunology, 19(2), 335-9.
Isa MB, et al. Measles Virus-specific IgG4 Antibody Titer as a Serologic Marker of Post-vaccinal Immune Response. Viral Immunol. 2006;19(2):335-9. PubMed PMID: 16817776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measles virus-specific IgG4 antibody titer as a serologic marker of post-vaccinal immune response. AU - Isa,María B, AU - Martínez,Laura C, AU - Ferreyra,Leonardo J, AU - Giordano,Miguel O, AU - Barril,Patricia A, AU - Massachessi,Gisela, AU - Nates,Silvia V, PY - 2006/7/5/pubmed PY - 2006/9/29/medline PY - 2006/7/5/entrez SP - 335 EP - 9 JF - Viral immunology JO - Viral Immunol VL - 19 IS - 2 N2 - In previous research, we concluded that measles virus specific IgG4 antibody titer could be used to differentiate between natural [IgG4 GMT 80 (95% CI, 33 to 191)] and vaccinal source of measles infection [IgG4 GMT 13 (95% CI, 7 to 26)]. The aim of this paper is to show that this new serologic marker (IgG4 measles antibody titer) can be applied to help interpret rare but well documented cases of measles Ig M-positive results in vaccinated individuals who, 1-2 months after vaccination, developed rash and fever and therefore do not meet the criteria for post-vaccinal measles infection. Six measles IgM-positive serum samples obtained from measles vaccinated individuals who developed rash/fever 1 to 2 months post-vaccination were studied by Immunofluorescence assay for the quantification of IgG4 measles specific antibody. IgG4 antibody titers from all these samples were between 1:10-1:20, consequently, the IgM positive results from the study cases could be ascribed to post-vaccinal immune response. Thus, measles virus specific IgG4 antibody titer could be used as a serologic marker of post-vaccinal immune response. SN - 0882-8245 UR - https://www.unboundmedicine.com/medline/citation/16817776/Measles_virus_specific_IgG4_antibody_titer_as_a_serologic_marker_of_post_vaccinal_immune_response_ L2 - https://www.liebertpub.com/doi/10.1089/vim.2006.19.335?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -