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Sleep apnoea and quality of life in growth hormone (GH)-deficient adults before and after 6 months of GH replacement therapy.
Clin Endocrinol (Oxf). 2006 Jul; 65(1):98-105.CE

Abstract

OBJECTIVE

To investigate the sleep architecture and breathing as well as quality of life (QoL) in adults with GH deficiency (GHD) before and 6 months after GH replacement therapy.

DESIGN

A prospective observational study.

PATIENTS

Nineteen consecutive adults with GHD (11 men, eight women; mean age 53, range 21-73 years) were studied.

MEASUREMENTS

An overnight sleep study was performed and the Minor Symptom Evaluation Profile (MSEP), Functional Outcome of Sleep Questionnaire (FOSQ), Short Form 36 (SF-36) and Epworth Sleepiness Scale (ESS) questionnaires were applied at baseline and after the treatment period.

RESULTS

For the whole group, there were no significant changes in mean total sleep time (TST; 370 min vs. 374 min), proportion of slow-wave sleep (SWS; 17.8%vs. 18.4%) and rapid eye movement (REM) sleep (12.1%vs. 13.9%) on GH replacement. Mean apnoea-hypopnoea index (AHI) was high and remained unchanged (28.2/h before vs. 28.0/h following GH replacement). Twelve patients (63%) were found to have obstructive sleep apnoea (OSA; AHI >or= 10/h) at baseline. Compared with GH-deficient patients without OSA (AHI 3.9/h), the OSA patients (AHI 42.4/h) had less SWS (11.4%vs. 28.6%, P = 0.010) and REM sleep (10.1%vs. 15.5%, P = 0.036). A marginal increase was observed in REM sleep time (10.1% before vs. 12.7% after GH; P = 0.048) while SWS was unchanged in this group. Moreover, MSEP for General Well-being and Responsiveness, FOSQ scores for General Productivity, Activity Level and Vigilance as well as SF-36 domains for Vitality and Mental Health were improved.

CONCLUSIONS

Contrary to some previous observations in a smaller group of patients, our data suggest that GH therapy does not induce or aggravate OSA in GH-deficient adults. Moreover, GH therapy may improve some of the QoL dimensions in these patients.

Authors+Show Affiliations

Sleep Medicine Unit, Department of Neurorehabilitation, Skaraborg Hospital, Skoevde, Sweden. yuksel.peker@lungall.gu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16817827

Citation

Peker, Y, et al. "Sleep Apnoea and Quality of Life in Growth Hormone (GH)-deficient Adults Before and After 6 Months of GH Replacement Therapy." Clinical Endocrinology, vol. 65, no. 1, 2006, pp. 98-105.
Peker Y, Svensson J, Hedner J, et al. Sleep apnoea and quality of life in growth hormone (GH)-deficient adults before and after 6 months of GH replacement therapy. Clin Endocrinol (Oxf). 2006;65(1):98-105.
Peker, Y., Svensson, J., Hedner, J., Grote, L., & Johannsson, G. (2006). Sleep apnoea and quality of life in growth hormone (GH)-deficient adults before and after 6 months of GH replacement therapy. Clinical Endocrinology, 65(1), 98-105.
Peker Y, et al. Sleep Apnoea and Quality of Life in Growth Hormone (GH)-deficient Adults Before and After 6 Months of GH Replacement Therapy. Clin Endocrinol (Oxf). 2006;65(1):98-105. PubMed PMID: 16817827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep apnoea and quality of life in growth hormone (GH)-deficient adults before and after 6 months of GH replacement therapy. AU - Peker,Y, AU - Svensson,J, AU - Hedner,J, AU - Grote,L, AU - Johannsson,G, PY - 2006/7/5/pubmed PY - 2007/2/17/medline PY - 2006/7/5/entrez SP - 98 EP - 105 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 65 IS - 1 N2 - OBJECTIVE: To investigate the sleep architecture and breathing as well as quality of life (QoL) in adults with GH deficiency (GHD) before and 6 months after GH replacement therapy. DESIGN: A prospective observational study. PATIENTS: Nineteen consecutive adults with GHD (11 men, eight women; mean age 53, range 21-73 years) were studied. MEASUREMENTS: An overnight sleep study was performed and the Minor Symptom Evaluation Profile (MSEP), Functional Outcome of Sleep Questionnaire (FOSQ), Short Form 36 (SF-36) and Epworth Sleepiness Scale (ESS) questionnaires were applied at baseline and after the treatment period. RESULTS: For the whole group, there were no significant changes in mean total sleep time (TST; 370 min vs. 374 min), proportion of slow-wave sleep (SWS; 17.8%vs. 18.4%) and rapid eye movement (REM) sleep (12.1%vs. 13.9%) on GH replacement. Mean apnoea-hypopnoea index (AHI) was high and remained unchanged (28.2/h before vs. 28.0/h following GH replacement). Twelve patients (63%) were found to have obstructive sleep apnoea (OSA; AHI >or= 10/h) at baseline. Compared with GH-deficient patients without OSA (AHI 3.9/h), the OSA patients (AHI 42.4/h) had less SWS (11.4%vs. 28.6%, P = 0.010) and REM sleep (10.1%vs. 15.5%, P = 0.036). A marginal increase was observed in REM sleep time (10.1% before vs. 12.7% after GH; P = 0.048) while SWS was unchanged in this group. Moreover, MSEP for General Well-being and Responsiveness, FOSQ scores for General Productivity, Activity Level and Vigilance as well as SF-36 domains for Vitality and Mental Health were improved. CONCLUSIONS: Contrary to some previous observations in a smaller group of patients, our data suggest that GH therapy does not induce or aggravate OSA in GH-deficient adults. Moreover, GH therapy may improve some of the QoL dimensions in these patients. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/16817827/Sleep_apnoea_and_quality_of_life_in_growth_hormone__GH__deficient_adults_before_and_after_6_months_of_GH_replacement_therapy_ L2 - https://doi.org/10.1111/j.1365-2265.2006.02555.x DB - PRIME DP - Unbound Medicine ER -