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The role of the basolateral amygdala in stimulus-reward memory and extinction memory consolidation and in subsequent conditioned cued reinstatement of cocaine seeking.
Eur J Neurosci. 2006 May; 23(10):2809-13.EJ

Abstract

The consolidation of cue-cocaine associations and extinction learning (i.e. cue-no cocaine associations) into long-term memory probably regulates the long-lasting control of conditioned stimuli (CS) over cocaine-seeking behaviour, and the basolateral amygdala (BLA) may play a role in this phenomenon. To test this hypothesis, rats previously trained to self-administer cocaine underwent a single classical conditioning (CC) session, during which they received passive pairings of cocaine infusions and a novel light + tone stimulus complex. After additional self-administration sessions in the absence of CS presentation and subsequent extinction training sessions, the ability of the CS to reinstate cocaine-seeking on five test days was assessed. Rats received intra-BLA microinfusions of vehicle or the Na+-channel blocker tetrodotoxin (TTX) immediately after CC (consolidation of CS-cocaine associations) or immediately after reinstatement testing (consolidation of extinction learning). TTX administered immediately after CC attenuated subsequent CS-induced reinstatement. In contrast, TTX administered after the first reinstatement test impaired the extinction of cocaine-seeking behaviour during a second reinstatement test by disrupting extinction memory. Overall, these findings suggest that Na+ channel-mediated mechanisms within the BLA mediate the consolidation of both cocaine-stimulus association and extinction learning, two processes that have opposite effects on subsequent cue-induced cocaine-seeking behaviour.

Authors+Show Affiliations

Department of Psychology, University of North Carolina at Chapel Hill, 27599, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16817884

Citation

Fuchs, Rita A., et al. "The Role of the Basolateral Amygdala in Stimulus-reward Memory and Extinction Memory Consolidation and in Subsequent Conditioned Cued Reinstatement of Cocaine Seeking." The European Journal of Neuroscience, vol. 23, no. 10, 2006, pp. 2809-13.
Fuchs RA, Feltenstein MW, See RE. The role of the basolateral amygdala in stimulus-reward memory and extinction memory consolidation and in subsequent conditioned cued reinstatement of cocaine seeking. Eur J Neurosci. 2006;23(10):2809-13.
Fuchs, R. A., Feltenstein, M. W., & See, R. E. (2006). The role of the basolateral amygdala in stimulus-reward memory and extinction memory consolidation and in subsequent conditioned cued reinstatement of cocaine seeking. The European Journal of Neuroscience, 23(10), 2809-13.
Fuchs RA, Feltenstein MW, See RE. The Role of the Basolateral Amygdala in Stimulus-reward Memory and Extinction Memory Consolidation and in Subsequent Conditioned Cued Reinstatement of Cocaine Seeking. Eur J Neurosci. 2006;23(10):2809-13. PubMed PMID: 16817884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of the basolateral amygdala in stimulus-reward memory and extinction memory consolidation and in subsequent conditioned cued reinstatement of cocaine seeking. AU - Fuchs,Rita A, AU - Feltenstein,Matthew W, AU - See,Ronald E, PY - 2006/7/5/pubmed PY - 2006/8/5/medline PY - 2006/7/5/entrez SP - 2809 EP - 13 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 23 IS - 10 N2 - The consolidation of cue-cocaine associations and extinction learning (i.e. cue-no cocaine associations) into long-term memory probably regulates the long-lasting control of conditioned stimuli (CS) over cocaine-seeking behaviour, and the basolateral amygdala (BLA) may play a role in this phenomenon. To test this hypothesis, rats previously trained to self-administer cocaine underwent a single classical conditioning (CC) session, during which they received passive pairings of cocaine infusions and a novel light + tone stimulus complex. After additional self-administration sessions in the absence of CS presentation and subsequent extinction training sessions, the ability of the CS to reinstate cocaine-seeking on five test days was assessed. Rats received intra-BLA microinfusions of vehicle or the Na+-channel blocker tetrodotoxin (TTX) immediately after CC (consolidation of CS-cocaine associations) or immediately after reinstatement testing (consolidation of extinction learning). TTX administered immediately after CC attenuated subsequent CS-induced reinstatement. In contrast, TTX administered after the first reinstatement test impaired the extinction of cocaine-seeking behaviour during a second reinstatement test by disrupting extinction memory. Overall, these findings suggest that Na+ channel-mediated mechanisms within the BLA mediate the consolidation of both cocaine-stimulus association and extinction learning, two processes that have opposite effects on subsequent cue-induced cocaine-seeking behaviour. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/16817884/The_role_of_the_basolateral_amygdala_in_stimulus_reward_memory_and_extinction_memory_consolidation_and_in_subsequent_conditioned_cued_reinstatement_of_cocaine_seeking_ L2 - https://doi.org/10.1111/j.1460-9568.2006.04806.x DB - PRIME DP - Unbound Medicine ER -