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Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population--the Kalixanda study.

Abstract

BACKGROUND

The impact of gastro-oesophageal reflux symptoms on health-related quality of life in the general population is poorly characterized.

AIM

To identify the frequency of troublesome reflux symptoms associated with impaired health-related quality of life in the general population.

METHODS

A representative random sample of 3000 adult inhabitants of northern Sweden was surveyed using the validated Abdominal Symptom Questionnaire (response rate 74%). In total, 1001 random responders were endoscoped and assessed using the Short Form-36 Health Survey.

RESULTS

Complete data were obtained for 999 subjects: 6% reported reflux symptoms (heartburn and/or regurgitation) daily, 14% weekly and 20% less than weekly during the previous 3 months. Compared with no reflux symptoms, a clinically relevant impairment of health-related quality of life (>or=5 points and P < 0.05) was seen in all eight Short Form-36 dimensions for daily symptoms, in five dimensions for weekly symptoms and in one dimension for less than weekly symptoms. There were no meaningful differences in Short Form-36 scores between subjects with and without oesophagitis.

CONCLUSIONS

Most aspects of health-related quality of life were impaired in individuals with daily or weekly reflux symptoms. Troublesome reflux symptoms at least weekly may identify gastro-oesophageal reflux disease.

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  • Authors+Show Affiliations

    ,

    Center for Family Medicine, Karolinska Institutet, Stockholm, Sweden. jukka.ronkainen@fimnet.fi

    , , , , , ,

    Source

    Alimentary pharmacology & therapeutics 23:12 2006 Jun 15 pg 1725-33

    MeSH

    Adult
    Esophagitis
    Female
    Gastroesophageal Reflux
    Humans
    Male
    Patient Acceptance of Health Care
    Quality of Life
    Surveys and Questionnaires
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16817916

    Citation

    Ronkainen, J, et al. "Gastro-oesophageal Reflux Symptoms and Health-related Quality of Life in the Adult General Population--the Kalixanda Study." Alimentary Pharmacology & Therapeutics, vol. 23, no. 12, 2006, pp. 1725-33.
    Ronkainen J, Aro P, Storskrubb T, et al. Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population--the Kalixanda study. Aliment Pharmacol Ther. 2006;23(12):1725-33.
    Ronkainen, J., Aro, P., Storskrubb, T., Lind, T., Bolling-Sternevald, E., Junghard, O., ... Agreus, L. (2006). Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population--the Kalixanda study. Alimentary Pharmacology & Therapeutics, 23(12), pp. 1725-33.
    Ronkainen J, et al. Gastro-oesophageal Reflux Symptoms and Health-related Quality of Life in the Adult General Population--the Kalixanda Study. Aliment Pharmacol Ther. 2006 Jun 15;23(12):1725-33. PubMed PMID: 16817916.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population--the Kalixanda study. AU - Ronkainen,J, AU - Aro,P, AU - Storskrubb,T, AU - Lind,T, AU - Bolling-Sternevald,E, AU - Junghard,O, AU - Talley,N J, AU - Agreus,L, PY - 2006/7/5/pubmed PY - 2006/11/11/medline PY - 2006/7/5/entrez SP - 1725 EP - 33 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 23 IS - 12 N2 - BACKGROUND: The impact of gastro-oesophageal reflux symptoms on health-related quality of life in the general population is poorly characterized. AIM: To identify the frequency of troublesome reflux symptoms associated with impaired health-related quality of life in the general population. METHODS: A representative random sample of 3000 adult inhabitants of northern Sweden was surveyed using the validated Abdominal Symptom Questionnaire (response rate 74%). In total, 1001 random responders were endoscoped and assessed using the Short Form-36 Health Survey. RESULTS: Complete data were obtained for 999 subjects: 6% reported reflux symptoms (heartburn and/or regurgitation) daily, 14% weekly and 20% less than weekly during the previous 3 months. Compared with no reflux symptoms, a clinically relevant impairment of health-related quality of life (>or=5 points and P < 0.05) was seen in all eight Short Form-36 dimensions for daily symptoms, in five dimensions for weekly symptoms and in one dimension for less than weekly symptoms. There were no meaningful differences in Short Form-36 scores between subjects with and without oesophagitis. CONCLUSIONS: Most aspects of health-related quality of life were impaired in individuals with daily or weekly reflux symptoms. Troublesome reflux symptoms at least weekly may identify gastro-oesophageal reflux disease. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/16817916/Gastro_oesophageal_reflux_symptoms_and_health_related_quality_of_life_in_the_adult_general_population__the_Kalixanda_study_ L2 - https://doi.org/10.1111/j.1365-2036.2006.02952.x DB - PRIME DP - Unbound Medicine ER -