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Acetaldehyde involvement in positive and negative alcohol expectancies in han Chinese persons with alcoholism.
Arch Gen Psychiatry 2006; 63(7):817-23AG

Abstract

CONTEXT

The ALDH2*2 allele has been shown to be a protective factor against alcoholism in a normal population owing in part to the elevated blood level of acetaldehyde and its accompanying physiological discomforts after drinking alcohol. Despite the well-established link between the ALDH2*2 allele and the physiological discomforts after drinking, very little is known regarding the psychological expectancies of drinking among persons with alcoholism with different ALDH genotypes.

OBJECTIVES

To determine whether there are differences in craving, alcohol consumption, and alcohol outcome expectancies between persons with alcoholism who have the ALDH2*1/*2 genotype and persons with alcoholism who have the ALDH2*1/*1 genotype.

DESIGN

Cross-sectional survey.

SETTING

Six outpatient alcohol treatment facilities in Taiwan.

PARTICIPANTS

Ninety-eight persons with alcoholism who met the DSM-IV criteria for current alcohol dependence.

MAIN OUTCOME MEASURES

Alcohol Craving Scale, Form 90, and Alcohol Expectancies Scale scores.

RESULTS

Overall, the ALDH2*1/*2 group had lower negative alcohol outcome expectancies (F(4,93) = 2.43, P < or = .05, eta(p)2 = 0.10). Specifically, they had fewer expected negative outcomes in the social or interpersonal domain (P < .05) and the emotional and physical domain (P < or = .005) than did the ALDH2*1/*1 group. Moreover, the ALDH2*1/*2 group had higher positive alcohol outcome expectancies (F(7,90) = 2.36, P < .05, eta(p)2 = 0.16), and they had more expected positive outcomes in the relaxation and tension reduction domain (P < .05). The 2 groups did not differ in alcohol craving (P = .61) or consumption (P = .11).

CONCLUSIONS

Although the ALDH2*2 allele has been associated with negative physiological responses in normal samples in past research, the psychological expectancies of drinking are more positive and less negative for persons with alcoholism who have the ALDH2*1/*2 genotype. A role of acetaldehyde is implied in these effects, which seem to override the usual discomfort effects associated with protection against alcohol drinking. Future studies are needed to assess alcohol outcome expectancies at different phases of alcohol dependence and to evaluate the concurrent relationships of blood levels of acetaldehyde with physiological and psychological outcomes among persons with alcoholism who have different ALDH genotypes.

Authors+Show Affiliations

Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16818871

Citation

Hahn, Cheng-Yi, et al. "Acetaldehyde Involvement in Positive and Negative Alcohol Expectancies in Han Chinese Persons With Alcoholism." Archives of General Psychiatry, vol. 63, no. 7, 2006, pp. 817-23.
Hahn CY, Huang SY, Ko HC, et al. Acetaldehyde involvement in positive and negative alcohol expectancies in han Chinese persons with alcoholism. Arch Gen Psychiatry. 2006;63(7):817-23.
Hahn, C. Y., Huang, S. Y., Ko, H. C., Hsieh, C. H., Lee, I. H., Yeh, T. L., ... Lu, R. B. (2006). Acetaldehyde involvement in positive and negative alcohol expectancies in han Chinese persons with alcoholism. Archives of General Psychiatry, 63(7), pp. 817-23.
Hahn CY, et al. Acetaldehyde Involvement in Positive and Negative Alcohol Expectancies in Han Chinese Persons With Alcoholism. Arch Gen Psychiatry. 2006;63(7):817-23. PubMed PMID: 16818871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acetaldehyde involvement in positive and negative alcohol expectancies in han Chinese persons with alcoholism. AU - Hahn,Cheng-Yi, AU - Huang,San-Yuan, AU - Ko,Huei-Chen, AU - Hsieh,Chau-Hsiang, AU - Lee,I-Hui, AU - Yeh,Tzung-Lieh, AU - Yang,Yen-Kuang, AU - Lee,Jia-Fu, AU - Lin,Wei-Wen, AU - Lu,Ru-Band, PY - 2006/7/5/pubmed PY - 2006/8/4/medline PY - 2006/7/5/entrez SP - 817 EP - 23 JF - Archives of general psychiatry JO - Arch. Gen. Psychiatry VL - 63 IS - 7 N2 - CONTEXT: The ALDH2*2 allele has been shown to be a protective factor against alcoholism in a normal population owing in part to the elevated blood level of acetaldehyde and its accompanying physiological discomforts after drinking alcohol. Despite the well-established link between the ALDH2*2 allele and the physiological discomforts after drinking, very little is known regarding the psychological expectancies of drinking among persons with alcoholism with different ALDH genotypes. OBJECTIVES: To determine whether there are differences in craving, alcohol consumption, and alcohol outcome expectancies between persons with alcoholism who have the ALDH2*1/*2 genotype and persons with alcoholism who have the ALDH2*1/*1 genotype. DESIGN: Cross-sectional survey. SETTING: Six outpatient alcohol treatment facilities in Taiwan. PARTICIPANTS: Ninety-eight persons with alcoholism who met the DSM-IV criteria for current alcohol dependence. MAIN OUTCOME MEASURES: Alcohol Craving Scale, Form 90, and Alcohol Expectancies Scale scores. RESULTS: Overall, the ALDH2*1/*2 group had lower negative alcohol outcome expectancies (F(4,93) = 2.43, P < or = .05, eta(p)2 = 0.10). Specifically, they had fewer expected negative outcomes in the social or interpersonal domain (P < .05) and the emotional and physical domain (P < or = .005) than did the ALDH2*1/*1 group. Moreover, the ALDH2*1/*2 group had higher positive alcohol outcome expectancies (F(7,90) = 2.36, P < .05, eta(p)2 = 0.16), and they had more expected positive outcomes in the relaxation and tension reduction domain (P < .05). The 2 groups did not differ in alcohol craving (P = .61) or consumption (P = .11). CONCLUSIONS: Although the ALDH2*2 allele has been associated with negative physiological responses in normal samples in past research, the psychological expectancies of drinking are more positive and less negative for persons with alcoholism who have the ALDH2*1/*2 genotype. A role of acetaldehyde is implied in these effects, which seem to override the usual discomfort effects associated with protection against alcohol drinking. Future studies are needed to assess alcohol outcome expectancies at different phases of alcohol dependence and to evaluate the concurrent relationships of blood levels of acetaldehyde with physiological and psychological outcomes among persons with alcoholism who have different ALDH genotypes. SN - 0003-990X UR - https://www.unboundmedicine.com/medline/citation/16818871/Acetaldehyde_involvement_in_positive_and_negative_alcohol_expectancies_in_han_Chinese_persons_with_alcoholism_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=16818871.ui DB - PRIME DP - Unbound Medicine ER -