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Reduced cardiac uptake and enhanced washout of 123I-MIBG in pure autonomic failure occurs conjointly with Parkinson's disease and dementia with Lewy bodies.
J Nucl Med. 2006 Jul; 47(7):1099-101.JN

Abstract

The purpose of this study was to investigate myocardial uptake of 123I-metaiodobenzylguanidine (MIBG) in patients with pure autonomic failure (PAF), which has pathologic features in common with idiopathic Parkinson's disease (IPD) and dementia with Lewy bodies (DLB).

METHODS

Six patients with PAF, 130 with IPD, 21 with DLB, 9 with corticobasal degeneration (CBD), 11 with progressive supranuclear palsy (PSP), and 11 with multiple-system atrophy (MSA) underwent myocardial 123I-MIBG scintigraphy, as did 16 control patients.

RESULTS

Resulting heart-to-mediastinum (H/M) ratios were significantly lower in patients with PAF, IPD, or DLB than in patients with CBD, PSP, or MSA and in the controls. H/M ratios were lower for delayed images than for early ones in patients with PAF, IPD, or DLB, whereas the ratios were higher for delayed images in patients with CBD and in the controls.

CONCLUSION

Cardiac sympathetic denervation and enhanced washout of 123I-MIBG from sympathetic nerve terminals may develop in parallel in patients with PAF, IPD, or DLB.

Authors+Show Affiliations

Department of Neurology, Okayama Kyokuto Hospital, Kurata, Okayama, Japan. kkashi@kyokuto.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16818943

Citation

Kashihara, Kenichi, et al. "Reduced Cardiac Uptake and Enhanced Washout of 123I-MIBG in Pure Autonomic Failure Occurs Conjointly With Parkinson's Disease and Dementia With Lewy Bodies." Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, vol. 47, no. 7, 2006, pp. 1099-101.
Kashihara K, Ohno M, Kawada S, et al. Reduced cardiac uptake and enhanced washout of 123I-MIBG in pure autonomic failure occurs conjointly with Parkinson's disease and dementia with Lewy bodies. J Nucl Med. 2006;47(7):1099-101.
Kashihara, K., Ohno, M., Kawada, S., & Okumura, Y. (2006). Reduced cardiac uptake and enhanced washout of 123I-MIBG in pure autonomic failure occurs conjointly with Parkinson's disease and dementia with Lewy bodies. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 47(7), 1099-101.
Kashihara K, et al. Reduced Cardiac Uptake and Enhanced Washout of 123I-MIBG in Pure Autonomic Failure Occurs Conjointly With Parkinson's Disease and Dementia With Lewy Bodies. J Nucl Med. 2006;47(7):1099-101. PubMed PMID: 16818943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced cardiac uptake and enhanced washout of 123I-MIBG in pure autonomic failure occurs conjointly with Parkinson's disease and dementia with Lewy bodies. AU - Kashihara,Kenichi, AU - Ohno,Manabu, AU - Kawada,Sanami, AU - Okumura,Yoshihiro, PY - 2006/7/5/pubmed PY - 2006/8/17/medline PY - 2006/7/5/entrez SP - 1099 EP - 101 JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine JO - J Nucl Med VL - 47 IS - 7 N2 - UNLABELLED: The purpose of this study was to investigate myocardial uptake of 123I-metaiodobenzylguanidine (MIBG) in patients with pure autonomic failure (PAF), which has pathologic features in common with idiopathic Parkinson's disease (IPD) and dementia with Lewy bodies (DLB). METHODS: Six patients with PAF, 130 with IPD, 21 with DLB, 9 with corticobasal degeneration (CBD), 11 with progressive supranuclear palsy (PSP), and 11 with multiple-system atrophy (MSA) underwent myocardial 123I-MIBG scintigraphy, as did 16 control patients. RESULTS: Resulting heart-to-mediastinum (H/M) ratios were significantly lower in patients with PAF, IPD, or DLB than in patients with CBD, PSP, or MSA and in the controls. H/M ratios were lower for delayed images than for early ones in patients with PAF, IPD, or DLB, whereas the ratios were higher for delayed images in patients with CBD and in the controls. CONCLUSION: Cardiac sympathetic denervation and enhanced washout of 123I-MIBG from sympathetic nerve terminals may develop in parallel in patients with PAF, IPD, or DLB. SN - 0161-5505 UR - https://www.unboundmedicine.com/medline/citation/16818943/Reduced_cardiac_uptake_and_enhanced_washout_of_123I_MIBG_in_pure_autonomic_failure_occurs_conjointly_with_Parkinson's_disease_and_dementia_with_Lewy_bodies_ L2 - http://jnm.snmjournals.org/cgi/pmidlookup?view=long&pmid=16818943 DB - PRIME DP - Unbound Medicine ER -