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Changes in 24-h area-under-the-curve ghrelin values following diet-induced weight loss are associated with loss of fat-free mass, but not with changes in fat mass, insulin levels or insulin sensitivity.
Int J Obes (Lond). 2007 Feb; 31(2):385-9.IJ

Abstract

OBJECTIVE

To determine which parameters of body composition or metabolism best correlate with changes in 24 h ghrelin levels following weight loss.

DESIGN

A 3-month low-calorie diet followed by 3 months of weight stabilization.

SUBJECTS

Twelve overweight and obese adult men and women.

MEASUREMENTS

Body composition by underwater weighing, abdominal fat depots, leptin, ghrelin and parameters of insulin and lipid metabolism.

RESULTS

Increased 24 h ghrelin levels after weight loss correlated with decreases in body mass index, subcutaneous fat and fat-free mass (FFM), but not with changes in fat mass, fat cell size, leptin, insulin, insulin sensitivity, lipids or free fatty acid levels. The change in FFM correlated with the rise in ghrelin levels independently of body adiposity.

DISCUSSION

Alterations in FFM with diet-induced weight loss may play a role in ghrelin regulation. Changes in ghrelin levels could, then, serve as an integrative signal reflecting changes in FFM to hypothalamic centers controlling energy homeostasis.

Authors+Show Affiliations

Department of Medicine, Center for the Study of Weight Regulation and Associated Disorders, Oregon Health & Science University, Portland, OR, USA. purnellj@ohsu.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16819531

Citation

Purnell, J Q., et al. "Changes in 24-h Area-under-the-curve Ghrelin Values Following Diet-induced Weight Loss Are Associated With Loss of Fat-free Mass, but Not With Changes in Fat Mass, Insulin Levels or Insulin Sensitivity." International Journal of Obesity (2005), vol. 31, no. 2, 2007, pp. 385-9.
Purnell JQ, Cummings D, Weigle DS. Changes in 24-h area-under-the-curve ghrelin values following diet-induced weight loss are associated with loss of fat-free mass, but not with changes in fat mass, insulin levels or insulin sensitivity. Int J Obes (Lond). 2007;31(2):385-9.
Purnell, J. Q., Cummings, D., & Weigle, D. S. (2007). Changes in 24-h area-under-the-curve ghrelin values following diet-induced weight loss are associated with loss of fat-free mass, but not with changes in fat mass, insulin levels or insulin sensitivity. International Journal of Obesity (2005), 31(2), 385-9.
Purnell JQ, Cummings D, Weigle DS. Changes in 24-h Area-under-the-curve Ghrelin Values Following Diet-induced Weight Loss Are Associated With Loss of Fat-free Mass, but Not With Changes in Fat Mass, Insulin Levels or Insulin Sensitivity. Int J Obes (Lond). 2007;31(2):385-9. PubMed PMID: 16819531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in 24-h area-under-the-curve ghrelin values following diet-induced weight loss are associated with loss of fat-free mass, but not with changes in fat mass, insulin levels or insulin sensitivity. AU - Purnell,J Q, AU - Cummings,D, AU - Weigle,D S, Y1 - 2006/07/04/ PY - 2006/7/5/pubmed PY - 2007/4/24/medline PY - 2006/7/5/entrez SP - 385 EP - 9 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 31 IS - 2 N2 - OBJECTIVE: To determine which parameters of body composition or metabolism best correlate with changes in 24 h ghrelin levels following weight loss. DESIGN: A 3-month low-calorie diet followed by 3 months of weight stabilization. SUBJECTS: Twelve overweight and obese adult men and women. MEASUREMENTS: Body composition by underwater weighing, abdominal fat depots, leptin, ghrelin and parameters of insulin and lipid metabolism. RESULTS: Increased 24 h ghrelin levels after weight loss correlated with decreases in body mass index, subcutaneous fat and fat-free mass (FFM), but not with changes in fat mass, fat cell size, leptin, insulin, insulin sensitivity, lipids or free fatty acid levels. The change in FFM correlated with the rise in ghrelin levels independently of body adiposity. DISCUSSION: Alterations in FFM with diet-induced weight loss may play a role in ghrelin regulation. Changes in ghrelin levels could, then, serve as an integrative signal reflecting changes in FFM to hypothalamic centers controlling energy homeostasis. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16819531/Changes_in_24_h_area_under_the_curve_ghrelin_values_following_diet_induced_weight_loss_are_associated_with_loss_of_fat_free_mass_but_not_with_changes_in_fat_mass_insulin_levels_or_insulin_sensitivity_ L2 - http://dx.doi.org/10.1038/sj.ijo.0803401 DB - PRIME DP - Unbound Medicine ER -