Tags

Type your tag names separated by a space and hit enter

Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease.
Arch Dis Child 2007; 92(1):43-7AD

Abstract

BACKGROUND

Evidence of premature atherosclerosis and systemic arterial stiffening in patients after Kawasaki disease is accumulating.

AIM

To test the hypothesis that carotid intima-media thickness (IMT), a surrogate marker of atherosclerosis, is associated with systemic arterial stiffness in children after Kawasaki disease.

METHODS

A cohort of 72 patients was studied, comprising 26 patients with Kawasaki disease and coronary aneurysms (group I), 24 patients with Kawasaki disease and normal coronary arteries (group II) and 22 healthy age-matched children (group III). The carotid IMT, carotid artery stiffness index, brachioradial pulse wave velocity (PWV), fasting total cholesterol, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol were determined and compared among the three groups.

RESULTS

The carotid IMT was related to indices of arterial stiffness, and significant determinants of carotid IMT were identified by multivariate analysis. The mean (standard deviation (SD)) carotid IMT of both group I (0.41 (0.04) mm) and group II (0.39 (0.04) mm) was significantly greater than that of group III (0.36 (0.04) mm; p<0.001 and p = 0.008, respectively). For the entire cohort, carotid IMT correlated positively with LDL cholesterol (r = 0.31, p = 0.009), carotid artery stiffness index (r = 0.40, p = 0.001) and brachioradial PWV (r = 0.28, p = 0.016), but not with age, body mass index, systemic blood pressure, and HDL and total cholesterol. Multiple linear regression analysis identified carotid artery stiffness index (beta = 0.25, p = 0.028) and subject grouping (beta = -0.39, p = 0.001; model R(2) = 0.29) as significant correlates of carotid IMT.

CONCLUSION

The increased carotid IMT in children after Kawasaki disease is associated with systemic arterial stiffening.

Authors+Show Affiliations

Department of Paediatrics and Adolescent Medicine, Division of Paediatric Cardiology, Grantham Hospital, The University of Hong Kong, Hong Kong, China. xfcheung@hkucc.hku.hkNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16820386

Citation

Cheung, Y-f, et al. "Relationship Between Carotid Intima-media Thickness and Arterial Stiffness in Children After Kawasaki Disease." Archives of Disease in Childhood, vol. 92, no. 1, 2007, pp. 43-7.
Cheung YF, Wong SJ, Ho MH. Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease. Arch Dis Child. 2007;92(1):43-7.
Cheung, Y. F., Wong, S. J., & Ho, M. H. (2007). Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease. Archives of Disease in Childhood, 92(1), pp. 43-7.
Cheung YF, Wong SJ, Ho MH. Relationship Between Carotid Intima-media Thickness and Arterial Stiffness in Children After Kawasaki Disease. Arch Dis Child. 2007;92(1):43-7. PubMed PMID: 16820386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease. AU - Cheung,Y-f, AU - Wong,S J, AU - Ho,M H K, Y1 - 2006/07/04/ PY - 2006/7/6/pubmed PY - 2007/1/17/medline PY - 2006/7/6/entrez SP - 43 EP - 7 JF - Archives of disease in childhood JO - Arch. Dis. Child. VL - 92 IS - 1 N2 - BACKGROUND: Evidence of premature atherosclerosis and systemic arterial stiffening in patients after Kawasaki disease is accumulating. AIM: To test the hypothesis that carotid intima-media thickness (IMT), a surrogate marker of atherosclerosis, is associated with systemic arterial stiffness in children after Kawasaki disease. METHODS: A cohort of 72 patients was studied, comprising 26 patients with Kawasaki disease and coronary aneurysms (group I), 24 patients with Kawasaki disease and normal coronary arteries (group II) and 22 healthy age-matched children (group III). The carotid IMT, carotid artery stiffness index, brachioradial pulse wave velocity (PWV), fasting total cholesterol, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol were determined and compared among the three groups. RESULTS: The carotid IMT was related to indices of arterial stiffness, and significant determinants of carotid IMT were identified by multivariate analysis. The mean (standard deviation (SD)) carotid IMT of both group I (0.41 (0.04) mm) and group II (0.39 (0.04) mm) was significantly greater than that of group III (0.36 (0.04) mm; p<0.001 and p = 0.008, respectively). For the entire cohort, carotid IMT correlated positively with LDL cholesterol (r = 0.31, p = 0.009), carotid artery stiffness index (r = 0.40, p = 0.001) and brachioradial PWV (r = 0.28, p = 0.016), but not with age, body mass index, systemic blood pressure, and HDL and total cholesterol. Multiple linear regression analysis identified carotid artery stiffness index (beta = 0.25, p = 0.028) and subject grouping (beta = -0.39, p = 0.001; model R(2) = 0.29) as significant correlates of carotid IMT. CONCLUSION: The increased carotid IMT in children after Kawasaki disease is associated with systemic arterial stiffening. SN - 1468-2044 UR - https://www.unboundmedicine.com/medline/citation/16820386/Relationship_between_carotid_intima_media_thickness_and_arterial_stiffness_in_children_after_Kawasaki_disease_ L2 - http://adc.bmj.com/cgi/pmidlookup?view=long&amp;pmid=16820386 DB - PRIME DP - Unbound Medicine ER -