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Comparative analysis of autoantibodies against a-fodrin in serum, tear fluid, and saliva from patients with Sjögren's syndrome.
J Rheumatol. 2006 Jul; 33(7):1289-92.JR

Abstract

OBJECTIVE

To evaluate levels of IgA and IgG antibodies against a-fodrin in serum, tear fluid, and saliva and compare them with anti-Ro and anti-La antibody levels in the same samples of patients with Sjögren's syndrome (SS).

METHODS

Samples from 25 patients with SS (17 primary and 8 secondary), 8 patients with systemic lupus erythematosus (SLE), and 7 patients with rheumatoid arthritis (RA) as well as 20 healthy blood donor controls were collected. Antibodies were measured using ELISA.

RESULTS

Although 40% of patients with primary SS had IgG anti-a-fodrin in their sera, it was also found in 36% and 32% of samples of their tear fluid and saliva, respectively. IgA a-fodrin antibodies were detected in 32% of SS sera, 20% of tear fluid samples, and 32% of saliva samples. Although the level of IgG anti-a-fodrin was significantly greater in serum, tear fluid, and saliva of SS patients compared to controls (p < 0.001), a significant difference was observed only in serum and saliva. While anti-Ro was detected in 48%, 56%, and 24% of serum, tear fluid, and saliva samples, respectively, anti-La was found in 40%, 44%, and 28%. Significant association was observed between serum IgG antibodies against a-fodrin and dry eye symptom score and rose bengal staining score. A negative association was also noted between tear IgA antibodies against a-fodrin and Schirmer I test.

CONCLUSION

Correlation of IgG and IgA antibodies against a-fodrin with the severity of eye involvement suggests that these autoantibodies may be considered activation markers of SS.

Authors+Show Affiliations

Department of Rheumatology, and the Faculties of Health Education, University of Marmara Medical School, Istanbul, Turkey. suleyavuz@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16821267

Citation

Yavuz, Sule, et al. "Comparative Analysis of Autoantibodies Against A-fodrin in Serum, Tear Fluid, and Saliva From Patients With Sjögren's Syndrome." The Journal of Rheumatology, vol. 33, no. 7, 2006, pp. 1289-92.
Yavuz S, Toker E, Bicakcigil M, et al. Comparative analysis of autoantibodies against a-fodrin in serum, tear fluid, and saliva from patients with Sjögren's syndrome. J Rheumatol. 2006;33(7):1289-92.
Yavuz, S., Toker, E., Bicakcigil, M., Mumcu, G., & Cakir, S. (2006). Comparative analysis of autoantibodies against a-fodrin in serum, tear fluid, and saliva from patients with Sjögren's syndrome. The Journal of Rheumatology, 33(7), 1289-92.
Yavuz S, et al. Comparative Analysis of Autoantibodies Against A-fodrin in Serum, Tear Fluid, and Saliva From Patients With Sjögren's Syndrome. J Rheumatol. 2006;33(7):1289-92. PubMed PMID: 16821267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative analysis of autoantibodies against a-fodrin in serum, tear fluid, and saliva from patients with Sjögren's syndrome. AU - Yavuz,Sule, AU - Toker,Ebru, AU - Bicakcigil,Muge, AU - Mumcu,Gonca, AU - Cakir,Sezen, PY - 2006/7/6/pubmed PY - 2006/11/9/medline PY - 2006/7/6/entrez SP - 1289 EP - 92 JF - The Journal of rheumatology JO - J Rheumatol VL - 33 IS - 7 N2 - OBJECTIVE: To evaluate levels of IgA and IgG antibodies against a-fodrin in serum, tear fluid, and saliva and compare them with anti-Ro and anti-La antibody levels in the same samples of patients with Sjögren's syndrome (SS). METHODS: Samples from 25 patients with SS (17 primary and 8 secondary), 8 patients with systemic lupus erythematosus (SLE), and 7 patients with rheumatoid arthritis (RA) as well as 20 healthy blood donor controls were collected. Antibodies were measured using ELISA. RESULTS: Although 40% of patients with primary SS had IgG anti-a-fodrin in their sera, it was also found in 36% and 32% of samples of their tear fluid and saliva, respectively. IgA a-fodrin antibodies were detected in 32% of SS sera, 20% of tear fluid samples, and 32% of saliva samples. Although the level of IgG anti-a-fodrin was significantly greater in serum, tear fluid, and saliva of SS patients compared to controls (p < 0.001), a significant difference was observed only in serum and saliva. While anti-Ro was detected in 48%, 56%, and 24% of serum, tear fluid, and saliva samples, respectively, anti-La was found in 40%, 44%, and 28%. Significant association was observed between serum IgG antibodies against a-fodrin and dry eye symptom score and rose bengal staining score. A negative association was also noted between tear IgA antibodies against a-fodrin and Schirmer I test. CONCLUSION: Correlation of IgG and IgA antibodies against a-fodrin with the severity of eye involvement suggests that these autoantibodies may be considered activation markers of SS. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/16821267/Comparative_analysis_of_autoantibodies_against_a_fodrin_in_serum_tear_fluid_and_saliva_from_patients_with_Sjögren's_syndrome_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=16821267 DB - PRIME DP - Unbound Medicine ER -