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Lack of effect of 4 weeks of oral H1 antagonist on bronchial responsiveness.
Eur Respir J. 1991 May; 4(5):575-9.ER

Abstract

Ten patients with stable chronic asthma completed a randomized double-blind placebo controlled crossover study examining the effect of 120mg terfenadine twice daily for 4 weeks on bronchial responsiveness. Bronchial responsiveness was measured by methacholine inhalation tests performed by the tidal breathing technique at 0, 2 and 4 weeks of active and placebo treatment periods separated by a one week washout period. There were no significant differences in mean baseline forced expired volume in 1 sec (FEV1) for placebo and terfenadine treatments (p greater than 0.05) and there were no differences between geometric mean provocative concentrations of methacholine to cause a 20% fall in FEV1 (PC20M) at 2 and 4 weeks of terfenadine (0.89 and 0.99 mg.ml.1) from placebo (0.94 and 0.84 mg.ml.1) (p greater than 0.05). Examination of individual PC20M values during terfenadine treatment showed that 5 patients had PC20M's outside their 95% confidence interval; 2 increased both 2 and 4 week values, 1 increased one value and 2 decreased one value each. It is concluded that terfenadine does not produce clinically significant changes in stable asthmatics.

Authors+Show Affiliations

Dept of Respiratory Medicine, Flinders Medical Centre, Bedford Park, South Australia.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1682159

Citation

Ruffin, R E., and K M. Latimer. "Lack of Effect of 4 Weeks of Oral H1 Antagonist On Bronchial Responsiveness." The European Respiratory Journal, vol. 4, no. 5, 1991, pp. 575-9.
Ruffin RE, Latimer KM. Lack of effect of 4 weeks of oral H1 antagonist on bronchial responsiveness. Eur Respir J. 1991;4(5):575-9.
Ruffin, R. E., & Latimer, K. M. (1991). Lack of effect of 4 weeks of oral H1 antagonist on bronchial responsiveness. The European Respiratory Journal, 4(5), 575-9.
Ruffin RE, Latimer KM. Lack of Effect of 4 Weeks of Oral H1 Antagonist On Bronchial Responsiveness. Eur Respir J. 1991;4(5):575-9. PubMed PMID: 1682159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of effect of 4 weeks of oral H1 antagonist on bronchial responsiveness. AU - Ruffin,R E, AU - Latimer,K M, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 575 EP - 9 JF - The European respiratory journal JO - Eur. Respir. J. VL - 4 IS - 5 N2 - Ten patients with stable chronic asthma completed a randomized double-blind placebo controlled crossover study examining the effect of 120mg terfenadine twice daily for 4 weeks on bronchial responsiveness. Bronchial responsiveness was measured by methacholine inhalation tests performed by the tidal breathing technique at 0, 2 and 4 weeks of active and placebo treatment periods separated by a one week washout period. There were no significant differences in mean baseline forced expired volume in 1 sec (FEV1) for placebo and terfenadine treatments (p greater than 0.05) and there were no differences between geometric mean provocative concentrations of methacholine to cause a 20% fall in FEV1 (PC20M) at 2 and 4 weeks of terfenadine (0.89 and 0.99 mg.ml.1) from placebo (0.94 and 0.84 mg.ml.1) (p greater than 0.05). Examination of individual PC20M values during terfenadine treatment showed that 5 patients had PC20M's outside their 95% confidence interval; 2 increased both 2 and 4 week values, 1 increased one value and 2 decreased one value each. It is concluded that terfenadine does not produce clinically significant changes in stable asthmatics. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/1682159/Lack_of_effect_of_4_weeks_of_oral_H1_antagonist_on_bronchial_responsiveness_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -