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Association study of ACE2 (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population.
Clin Sci (Lond). 2006 Nov; 111(5):333-40.CS

Abstract

Results are accumulating that ACE2 (angiotensin I-converting enzyme 2) might act as a protective protein for cardiovascular diseases; however, only a few studies in human populations have been carried out. This prompted us to perform a case-control study to investigate the relationship of ACE2 polymorphisms with CHD (coronary heart disease) and MI (myocardial infarction). Three single nucleotide polymorphisms in the ACE2 gene (1075A/G, 8790A/G and 16854G/C) were genotyped by PCR-RFLP (restriction-fragment-length polymorphism) in 811 patients with CHD (of which 508 were patients with MI) and 905 normal controls in a Chinese population. The polymorphisms were in linkage disequilibrium (r(2)=0.854-0.973). Analyses were conducted by gender, because the ACE2 gene is on the X chromosome. In females, an association was detected with MI for 1075A/G (P=0.026; odds ratio=1.98) and 16854G/C (P=0.028; odds ratio=1.97) in recessive models after adjusting for covariates. In male subjects, two haplotypes (AAG and GGC) were common in frequency. In male subjects not consuming alcohol, the haplotype GGC was associated with a 1.76-fold risk of CHD [95% CI (confidence interval), 1.15-2.69; P=0.007] and a 1.77-fold risk of MI (95% CI, 1.12-2.81; P=0.015) with environmental factors adjusted, when compared with the most common haplotype AAG. In conclusion, the results of the present study indicate that common genetic variants in the ACE2 gene might impact on MI in females, and may possibly interact with alcohol consumption to affect the risk of CHD and MI in Chinese males.

Authors+Show Affiliations

Division of Population Genetics and Prevention, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16822235

Citation

Yang, Wei, et al. "Association Study of ACE2 (angiotensin I-converting Enzyme 2) Gene Polymorphisms With Coronary Heart Disease and Myocardial Infarction in a Chinese Han Population." Clinical Science (London, England : 1979), vol. 111, no. 5, 2006, pp. 333-40.
Yang W, Huang W, Su S, et al. Association study of ACE2 (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population. Clin Sci (Lond). 2006;111(5):333-40.
Yang, W., Huang, W., Su, S., Li, B., Zhao, W., Chen, S., & Gu, D. (2006). Association study of ACE2 (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population. Clinical Science (London, England : 1979), 111(5), 333-40.
Yang W, et al. Association Study of ACE2 (angiotensin I-converting Enzyme 2) Gene Polymorphisms With Coronary Heart Disease and Myocardial Infarction in a Chinese Han Population. Clin Sci (Lond). 2006;111(5):333-40. PubMed PMID: 16822235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association study of ACE2 (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population. AU - Yang,Wei, AU - Huang,Wentao, AU - Su,Shaoyong, AU - Li,Biao, AU - Zhao,Weiyan, AU - Chen,Shufeng, AU - Gu,Dongfeng, PY - 2006/7/11/pubmed PY - 2006/12/15/medline PY - 2006/7/11/entrez SP - 333 EP - 40 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 111 IS - 5 N2 - Results are accumulating that ACE2 (angiotensin I-converting enzyme 2) might act as a protective protein for cardiovascular diseases; however, only a few studies in human populations have been carried out. This prompted us to perform a case-control study to investigate the relationship of ACE2 polymorphisms with CHD (coronary heart disease) and MI (myocardial infarction). Three single nucleotide polymorphisms in the ACE2 gene (1075A/G, 8790A/G and 16854G/C) were genotyped by PCR-RFLP (restriction-fragment-length polymorphism) in 811 patients with CHD (of which 508 were patients with MI) and 905 normal controls in a Chinese population. The polymorphisms were in linkage disequilibrium (r(2)=0.854-0.973). Analyses were conducted by gender, because the ACE2 gene is on the X chromosome. In females, an association was detected with MI for 1075A/G (P=0.026; odds ratio=1.98) and 16854G/C (P=0.028; odds ratio=1.97) in recessive models after adjusting for covariates. In male subjects, two haplotypes (AAG and GGC) were common in frequency. In male subjects not consuming alcohol, the haplotype GGC was associated with a 1.76-fold risk of CHD [95% CI (confidence interval), 1.15-2.69; P=0.007] and a 1.77-fold risk of MI (95% CI, 1.12-2.81; P=0.015) with environmental factors adjusted, when compared with the most common haplotype AAG. In conclusion, the results of the present study indicate that common genetic variants in the ACE2 gene might impact on MI in females, and may possibly interact with alcohol consumption to affect the risk of CHD and MI in Chinese males. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/16822235/Association_study_of_ACE2__angiotensin_I_converting_enzyme_2__gene_polymorphisms_with_coronary_heart_disease_and_myocardial_infarction_in_a_Chinese_Han_population_ L2 - https://portlandpress.com/clinsci/article-lookup/doi/10.1042/CS20060020 DB - PRIME DP - Unbound Medicine ER -