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n -- 3 fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids.
Clin Sci (Lond) 2006; 111(4):289-94CS

Abstract

n--3 Fatty acids derived from fish oil reduce plasma triacylglycerols (triglycerides) and increase HDL-C (high-density lipoprotein cholesterol); however, the effect of n--3 fatty acid supplementation during pregnancy, a hyperlipidaemic state, remains unknown. We took the opportunity to investigate maternal lipid levels and blood pressure during and after pregnancy, and fetal lipid levels at birth, in a study that aimed primarily to examine the effect of fish oil supplementation during pregnancy on immune function in infants born to women with allergic disease. Eighty-three pregnant women who had allergic disease, but were otherwise healthy, completed the study. They were randomly allocated to receive fish oil or olive oil capsules, taken as 4 g/day, from 20 weeks of pregnancy until delivery. Compared with olive oil, fish oil supplementation did not alter triacylglycerols, total cholesterol, LDL-C (low-density lipoprotein cholesterol) or HDL-C during or after pregnancy. There was also no effect of fish oil on cord blood triacylglycerols, total cholesterol, LDL-C or HDL-C. Fish oil supplementation during pregnancy did not alter maternal blood pressure during or after pregnancy. The effects of fish oil on lipids and blood pressure in non-pregnant individuals appear to be lost when it is administered during pregnancy.

Authors+Show Affiliations

School of Medicine and Pharmacology, Royal Perth Hospital Unit, GPO Box X2213, Perth, WA 6847, Australia. anne.barden@uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16822237

Citation

Barden, Anne E., et al. "N -- 3 Fatty Acid Supplementation During Pregnancy in Women With Allergic Disease: Effects On Blood Pressure, and Maternal and Fetal Lipids." Clinical Science (London, England : 1979), vol. 111, no. 4, 2006, pp. 289-94.
Barden AE, Dunstan JA, Beilin LJ, et al. N -- 3 fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids. Clin Sci. 2006;111(4):289-94.
Barden, A. E., Dunstan, J. A., Beilin, L. J., Prescott, S. L., & Mori, T. A. (2006). N -- 3 fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids. Clinical Science (London, England : 1979), 111(4), pp. 289-94.
Barden AE, et al. N -- 3 Fatty Acid Supplementation During Pregnancy in Women With Allergic Disease: Effects On Blood Pressure, and Maternal and Fetal Lipids. Clin Sci. 2006;111(4):289-94. PubMed PMID: 16822237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - n -- 3 fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids. AU - Barden,Anne E, AU - Dunstan,Janet A, AU - Beilin,Lawrence J, AU - Prescott,Susan L, AU - Mori,Trevor A, PY - 2006/7/11/pubmed PY - 2007/2/21/medline PY - 2006/7/11/entrez SP - 289 EP - 94 JF - Clinical science (London, England : 1979) JO - Clin. Sci. VL - 111 IS - 4 N2 - n--3 Fatty acids derived from fish oil reduce plasma triacylglycerols (triglycerides) and increase HDL-C (high-density lipoprotein cholesterol); however, the effect of n--3 fatty acid supplementation during pregnancy, a hyperlipidaemic state, remains unknown. We took the opportunity to investigate maternal lipid levels and blood pressure during and after pregnancy, and fetal lipid levels at birth, in a study that aimed primarily to examine the effect of fish oil supplementation during pregnancy on immune function in infants born to women with allergic disease. Eighty-three pregnant women who had allergic disease, but were otherwise healthy, completed the study. They were randomly allocated to receive fish oil or olive oil capsules, taken as 4 g/day, from 20 weeks of pregnancy until delivery. Compared with olive oil, fish oil supplementation did not alter triacylglycerols, total cholesterol, LDL-C (low-density lipoprotein cholesterol) or HDL-C during or after pregnancy. There was also no effect of fish oil on cord blood triacylglycerols, total cholesterol, LDL-C or HDL-C. Fish oil supplementation during pregnancy did not alter maternal blood pressure during or after pregnancy. The effects of fish oil on lipids and blood pressure in non-pregnant individuals appear to be lost when it is administered during pregnancy. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/16822237/n____3_fatty_acid_supplementation_during_pregnancy_in_women_with_allergic_disease:_effects_on_blood_pressure_and_maternal_and_fetal_lipids_ L2 - http://clinsci.org/cgi/pmidlookup?view=long&pmid=16822237 DB - PRIME DP - Unbound Medicine ER -