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Magnetoencephalography in patients with tuberous sclerosis and localization-related epilepsy.
Epilepsia. 2006 Jun; 47(6):991-7.E

Abstract

PURPOSE

To clarify the usefulness of magnetoencephalography (MEG) for diagnosis of the spatial relations between spike foci and suspicious epileptogenic tubers on MRI in patients with tuberous sclerosis (TS) and to compare MEG spike foci with single-photon emission computed tomography (SPECT) findings.

METHODS

We analyzed magnetic fields of epileptic spike discharges in 15 patients with TS and localization-related epilepsy (LRE) by using MEG (a whole-head 204-channel magnetometer system). We investigated the spatial relation between the equivalent current dipoles (ECDs) of interictal spike discharges and visible cortical tubers on MRI. We also compared results of MEG and MRI with SPECT findings.

RESULTS

MEG detected a cluster of ECDs around one cortical tuber in six of 15 patients and clusters of ECDs around two cortical tubers in five patients. Interictal SPECT was disappointing in detection of epileptic foci in TS. However, MEG spike foci showed spatial consistency with ictal hyperperfusion areas in two patients. Three patients with single ECD clusters underwent surgical treatment: two have been seizure free, and one has obtained seizure reduction of >90%.

CONCLUSIONS

ECDs were located around visible tuber nodules. MEG enabled precise localization of the epileptic foci and provided crucial information for surgical treatment in patients with TS and partial epilepsy. TS patients showing a single ECD cluster on MEG may be appropriate candidates for surgical treatment.

Authors+Show Affiliations

Department of Homeostatic Regulation and Development, Niigata Graduate School of Medical and Dental Sciences, and Department of Pediatric Neurology, Epilepsy Center, Nishi-Niigata Chuo National Hospital, Niigata, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16822245

Citation

Kamimura, Takanori, et al. "Magnetoencephalography in Patients With Tuberous Sclerosis and Localization-related Epilepsy." Epilepsia, vol. 47, no. 6, 2006, pp. 991-7.
Kamimura T, Tohyama J, Oishi M, et al. Magnetoencephalography in patients with tuberous sclerosis and localization-related epilepsy. Epilepsia. 2006;47(6):991-7.
Kamimura, T., Tohyama, J., Oishi, M., Akasaka, N., Kanazawa, O., Sasagawa, M., Kato, M., Ohno, K., Masuda, H., Kameyama, S., & Uchiyama, M. (2006). Magnetoencephalography in patients with tuberous sclerosis and localization-related epilepsy. Epilepsia, 47(6), 991-7.
Kamimura T, et al. Magnetoencephalography in Patients With Tuberous Sclerosis and Localization-related Epilepsy. Epilepsia. 2006;47(6):991-7. PubMed PMID: 16822245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetoencephalography in patients with tuberous sclerosis and localization-related epilepsy. AU - Kamimura,Takanori, AU - Tohyama,Jun, AU - Oishi,Makoto, AU - Akasaka,Noriyuki, AU - Kanazawa,Osamu, AU - Sasagawa,Mutsuo, AU - Kato,Mitsuhiro, AU - Ohno,Kousaku, AU - Masuda,Hiroshi, AU - Kameyama,Shigeki, AU - Uchiyama,Makoto, PY - 2006/7/11/pubmed PY - 2006/7/29/medline PY - 2006/7/11/entrez SP - 991 EP - 7 JF - Epilepsia JO - Epilepsia VL - 47 IS - 6 N2 - PURPOSE: To clarify the usefulness of magnetoencephalography (MEG) for diagnosis of the spatial relations between spike foci and suspicious epileptogenic tubers on MRI in patients with tuberous sclerosis (TS) and to compare MEG spike foci with single-photon emission computed tomography (SPECT) findings. METHODS: We analyzed magnetic fields of epileptic spike discharges in 15 patients with TS and localization-related epilepsy (LRE) by using MEG (a whole-head 204-channel magnetometer system). We investigated the spatial relation between the equivalent current dipoles (ECDs) of interictal spike discharges and visible cortical tubers on MRI. We also compared results of MEG and MRI with SPECT findings. RESULTS: MEG detected a cluster of ECDs around one cortical tuber in six of 15 patients and clusters of ECDs around two cortical tubers in five patients. Interictal SPECT was disappointing in detection of epileptic foci in TS. However, MEG spike foci showed spatial consistency with ictal hyperperfusion areas in two patients. Three patients with single ECD clusters underwent surgical treatment: two have been seizure free, and one has obtained seizure reduction of >90%. CONCLUSIONS: ECDs were located around visible tuber nodules. MEG enabled precise localization of the epileptic foci and provided crucial information for surgical treatment in patients with TS and partial epilepsy. TS patients showing a single ECD cluster on MEG may be appropriate candidates for surgical treatment. SN - 0013-9580 UR - https://www.unboundmedicine.com/medline/citation/16822245/Magnetoencephalography_in_patients_with_tuberous_sclerosis_and_localization_related_epilepsy_ L2 - https://doi.org/10.1111/j.1528-1167.2006.00511.x DB - PRIME DP - Unbound Medicine ER -