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Comparison of a new composite index based on midlatency auditory evoked potentials and electroencephalographic parameters with bispectral index (BIS) during moderate propofol sedation.
Eur J Anaesthesiol. 2006 Nov; 23(11):931-6.EJ

Abstract

BACKGROUND AND OBJECTIVE

Derived parameters of the electroencephalogram and auditory evoked potentials can be used to determine depth of anaesthesia and sedation. However, it is not known whether any parameter can identify the occurrence of awareness in individual patients. We have compared the performance of bispectral index and a new composite index derived from auditory evoked potentials and the electroencephalogram (AAI 1.61) in predicting consciousness, explicit and implicit memory during moderate sedation with propofol.

METHODS

Twenty-one patients with spinal anaesthesia received intraoperatively propofol at the age-corrected C(50) for loss of consciousness and were presented test words via headphones. Bispectral index and AAI 1.61 (auditory evoked potentials, AEP-Monitor2) were recorded in parallel as well as the Observer's Assessment of Alertness/Sedation-score. Postoperatively, testing for explicit and implicit memory formation was performed.

RESULTS

Bispectral index and AAI 1.61 correlated well with loss of consciousness defined by an Observer's Assessment of Alertness/Sedation-score of 2 (identical P(K) of 0.87), but did not allow a prediction of postoperative explicit or implicit recall.

CONCLUSIONS

Both bispectral index and AAI may be indices of depth of sedation rather than indicators of memory formation, which persists during propofol sedation even after loss of consciousness.

Authors+Show Affiliations

Charité, Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Department of Anaesthesiology and Intensive Care Medicine, Berlin, Germany. daniel.hadzidiakos@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

16824245

Citation

Hadzidiakos, D, et al. "Comparison of a New Composite Index Based On Midlatency Auditory Evoked Potentials and Electroencephalographic Parameters With Bispectral Index (BIS) During Moderate Propofol Sedation." European Journal of Anaesthesiology, vol. 23, no. 11, 2006, pp. 931-6.
Hadzidiakos D, Petersen S, Baars J, et al. Comparison of a new composite index based on midlatency auditory evoked potentials and electroencephalographic parameters with bispectral index (BIS) during moderate propofol sedation. Eur J Anaesthesiol. 2006;23(11):931-6.
Hadzidiakos, D., Petersen, S., Baars, J., Herold, K., & Rehberg, B. (2006). Comparison of a new composite index based on midlatency auditory evoked potentials and electroencephalographic parameters with bispectral index (BIS) during moderate propofol sedation. European Journal of Anaesthesiology, 23(11), 931-6.
Hadzidiakos D, et al. Comparison of a New Composite Index Based On Midlatency Auditory Evoked Potentials and Electroencephalographic Parameters With Bispectral Index (BIS) During Moderate Propofol Sedation. Eur J Anaesthesiol. 2006;23(11):931-6. PubMed PMID: 16824245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of a new composite index based on midlatency auditory evoked potentials and electroencephalographic parameters with bispectral index (BIS) during moderate propofol sedation. AU - Hadzidiakos,D, AU - Petersen,S, AU - Baars,J, AU - Herold,K, AU - Rehberg,B, Y1 - 2006/07/07/ PY - 2006/05/26/accepted PY - 2006/7/11/pubmed PY - 2007/2/13/medline PY - 2006/7/11/entrez SP - 931 EP - 6 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 23 IS - 11 N2 - BACKGROUND AND OBJECTIVE: Derived parameters of the electroencephalogram and auditory evoked potentials can be used to determine depth of anaesthesia and sedation. However, it is not known whether any parameter can identify the occurrence of awareness in individual patients. We have compared the performance of bispectral index and a new composite index derived from auditory evoked potentials and the electroencephalogram (AAI 1.61) in predicting consciousness, explicit and implicit memory during moderate sedation with propofol. METHODS: Twenty-one patients with spinal anaesthesia received intraoperatively propofol at the age-corrected C(50) for loss of consciousness and were presented test words via headphones. Bispectral index and AAI 1.61 (auditory evoked potentials, AEP-Monitor2) were recorded in parallel as well as the Observer's Assessment of Alertness/Sedation-score. Postoperatively, testing for explicit and implicit memory formation was performed. RESULTS: Bispectral index and AAI 1.61 correlated well with loss of consciousness defined by an Observer's Assessment of Alertness/Sedation-score of 2 (identical P(K) of 0.87), but did not allow a prediction of postoperative explicit or implicit recall. CONCLUSIONS: Both bispectral index and AAI may be indices of depth of sedation rather than indicators of memory formation, which persists during propofol sedation even after loss of consciousness. SN - 0265-0215 UR - https://www.unboundmedicine.com/medline/citation/16824245/Comparison_of_a_new_composite_index_based_on_midlatency_auditory_evoked_potentials_and_electroencephalographic_parameters_with_bispectral_index__BIS__during_moderate_propofol_sedation_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16824245.ui DB - PRIME DP - Unbound Medicine ER -