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[Bone mineral density in inflammatory bowel diseases in children].
Med Wieku Rozwoj. 2006 Apr-Jun; 10(2):445-51.MW

Abstract

OBJECTIVE

determination of bone mineral density in children treated because of inflammatory bowel diseases.

MATERIAL AND METHODS

42 patients were included: 21 with ulcerative colitis and 21 with Crohn's disease. The duration of illness was from 2.0-24.0 months. Glucocorticoid therapy was applied in 92.9% of patients with the duration from 4-1680 days. The cumulative doses of glucocorticoids were from 160 to 25900 mg. Bone mineral density (BMD) and z-score of L1-L4 were assessed by dual-energy X-ray absorptiometry (DEXA). The mean BMD of L1-L4 were measured in g/cm2 and compared with referential values for gender and age. Osteopenia (ope) mean z-score from -1 to -2 SD, osteoporosis (opo) < -2 SD were accepted.

RESULTS

BMD values varied from 0.531 to 1.301 g/cm. Z-score values varied from 0.9 to -5.6 SD. Bone mineral disturbances occurred in 57.2% of cases and it was equally both in 28.6% of cases osteoporosis and osteopenia. In ulcerative colitis osteopenia was predominant (23.8%), while in Crohn's disease osteoporosis occurred more often (23.8%). There was no significance in the duration time of the disease and BMD and z-score. The significant difference was found in the duration of steroid therapy and z-score. No association was found among cumulative dose of steroids and z-score. No significant differences were found in BMD and z-score of lumbar spine in ulcerative colitis and Crohn's disease.

CONCLUSIONS

1. Bone mineral disturbances often complicate inflammatory bowel diseases in children. 2. The association among the duration time of steroid therapy and bone mineral density was confirmed. 3. No significant differences were found in bone mineral density among colitis ulcerasa and Crohn's disease cases.

Authors+Show Affiliations

Klinika Pediatrii, Gastroenterologii i Onkologii Dzieciecej, Akademia Medyczna, ul. Nowe Ogrody 1-6, 80-803 Gdansk, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

16825715

Citation

Szumera, Małgorzata, et al. "[Bone Mineral Density in Inflammatory Bowel Diseases in Children]." Medycyna Wieku Rozwojowego, vol. 10, no. 2, 2006, pp. 445-51.
Szumera M, Landowski P, Kamińska B, et al. [Bone mineral density in inflammatory bowel diseases in children]. Med Wieku Rozwoj. 2006;10(2):445-51.
Szumera, M., Landowski, P., Kamińska, B., Góra-Gebka, M., Popadiuk, S., & Renke, J. (2006). [Bone mineral density in inflammatory bowel diseases in children]. Medycyna Wieku Rozwojowego, 10(2), 445-51.
Szumera M, et al. [Bone Mineral Density in Inflammatory Bowel Diseases in Children]. Med Wieku Rozwoj. 2006 Apr-Jun;10(2):445-51. PubMed PMID: 16825715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bone mineral density in inflammatory bowel diseases in children]. AU - Szumera,Małgorzata, AU - Landowski,Piotr, AU - Kamińska,Barbara, AU - Góra-Gebka,Magdalena, AU - Popadiuk,Stefan, AU - Renke,Joanna, PY - 2006/7/11/pubmed PY - 2007/2/28/medline PY - 2006/7/11/entrez SP - 445 EP - 51 JF - Medycyna wieku rozwojowego JO - Med Wieku Rozwoj VL - 10 IS - 2 N2 - OBJECTIVE: determination of bone mineral density in children treated because of inflammatory bowel diseases. MATERIAL AND METHODS: 42 patients were included: 21 with ulcerative colitis and 21 with Crohn's disease. The duration of illness was from 2.0-24.0 months. Glucocorticoid therapy was applied in 92.9% of patients with the duration from 4-1680 days. The cumulative doses of glucocorticoids were from 160 to 25900 mg. Bone mineral density (BMD) and z-score of L1-L4 were assessed by dual-energy X-ray absorptiometry (DEXA). The mean BMD of L1-L4 were measured in g/cm2 and compared with referential values for gender and age. Osteopenia (ope) mean z-score from -1 to -2 SD, osteoporosis (opo) < -2 SD were accepted. RESULTS: BMD values varied from 0.531 to 1.301 g/cm. Z-score values varied from 0.9 to -5.6 SD. Bone mineral disturbances occurred in 57.2% of cases and it was equally both in 28.6% of cases osteoporosis and osteopenia. In ulcerative colitis osteopenia was predominant (23.8%), while in Crohn's disease osteoporosis occurred more often (23.8%). There was no significance in the duration time of the disease and BMD and z-score. The significant difference was found in the duration of steroid therapy and z-score. No association was found among cumulative dose of steroids and z-score. No significant differences were found in BMD and z-score of lumbar spine in ulcerative colitis and Crohn's disease. CONCLUSIONS: 1. Bone mineral disturbances often complicate inflammatory bowel diseases in children. 2. The association among the duration time of steroid therapy and bone mineral density was confirmed. 3. No significant differences were found in bone mineral density among colitis ulcerasa and Crohn's disease cases. UR - https://www.unboundmedicine.com/medline/citation/16825715/[Bone_mineral_density_in_inflammatory_bowel_diseases_in_children]_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -