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Is HCl duloxetine effective in the management of urinary stress incontinence after radical prostatectomy?
Urol Int. 2006; 77(1):9-12.UI

Abstract

INTRODUCTION

Up to 70% of patients who undergo radical prostatectomy complain about urine leakage, but persistent stress incontinence 1 year after surgery affects <5% of them. HCl duloxetine is a dual serotonin and norepinephrine reuptake inhibitor that relieves the symptoms of stress urinary incontinence. The purpose of this study was to evaluate the efficacy of HCl duloxetine in the management of urinary incontinence after radical prostatectomy and its impact in urodynamic parameters such as maximal urethral closure pressure (MUCP), abdominal leak point pressure (ALPP) and retrograde leak point pressure (RLPP).

MATERIAL AND METHODS

The study included 18 men with stress urinary incontinence 12 months after radical prostatectomy. All underwent a pad test to quantify the degree of urine loss and a urodynamic evaluation before and after a three month treatment with HCl duloxetine. The intrinsic sphincter was evaluated by ALPP and RLPP and the striated sphincter by MUCP.

RESULTS

At the pretreatment evaluation the mean ALPP was 52.1 cm H(2)O, the mean MUCP was 52.5 cm H(2)O and the mean RLPP was 43.1 cm H(2)O. After 3 months of HCl duloxetine treatment the mean ALPP was 59.1 cm H(2)O, the mean MUCP was 67.3 cm H(2)O and the mean RLPP was 45.1 cm H(2)O. There was a statistically significant correlation among RLPP, MUCP and ALPP before treatment. After HCl duloxetine treatment there was significant correlation between RLPP and ALPP.

CONCLUSION

The use of HCl duloxetine results in mild increase of MUCP and in significant reduction of urine loss. Its action on the extrinsic sphincter does not provide a complete treatment option for postprostatectomy incontinence.

Authors+Show Affiliations

Urology Department, ELPIS Hospital, Volos, Greece. zahariou@otenet.grNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16825808

Citation

Zahariou, Athanasios, et al. "Is HCl Duloxetine Effective in the Management of Urinary Stress Incontinence After Radical Prostatectomy?" Urologia Internationalis, vol. 77, no. 1, 2006, pp. 9-12.
Zahariou A, Papaioannou P, Kalogirou G. Is HCl duloxetine effective in the management of urinary stress incontinence after radical prostatectomy? Urol Int. 2006;77(1):9-12.
Zahariou, A., Papaioannou, P., & Kalogirou, G. (2006). Is HCl duloxetine effective in the management of urinary stress incontinence after radical prostatectomy? Urologia Internationalis, 77(1), 9-12.
Zahariou A, Papaioannou P, Kalogirou G. Is HCl Duloxetine Effective in the Management of Urinary Stress Incontinence After Radical Prostatectomy. Urol Int. 2006;77(1):9-12. PubMed PMID: 16825808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is HCl duloxetine effective in the management of urinary stress incontinence after radical prostatectomy? AU - Zahariou,Athanasios, AU - Papaioannou,Polyanthi, AU - Kalogirou,Georgia, PY - 2006/7/11/pubmed PY - 2006/12/21/medline PY - 2006/7/11/entrez SP - 9 EP - 12 JF - Urologia internationalis JO - Urol Int VL - 77 IS - 1 N2 - INTRODUCTION: Up to 70% of patients who undergo radical prostatectomy complain about urine leakage, but persistent stress incontinence 1 year after surgery affects <5% of them. HCl duloxetine is a dual serotonin and norepinephrine reuptake inhibitor that relieves the symptoms of stress urinary incontinence. The purpose of this study was to evaluate the efficacy of HCl duloxetine in the management of urinary incontinence after radical prostatectomy and its impact in urodynamic parameters such as maximal urethral closure pressure (MUCP), abdominal leak point pressure (ALPP) and retrograde leak point pressure (RLPP). MATERIAL AND METHODS: The study included 18 men with stress urinary incontinence 12 months after radical prostatectomy. All underwent a pad test to quantify the degree of urine loss and a urodynamic evaluation before and after a three month treatment with HCl duloxetine. The intrinsic sphincter was evaluated by ALPP and RLPP and the striated sphincter by MUCP. RESULTS: At the pretreatment evaluation the mean ALPP was 52.1 cm H(2)O, the mean MUCP was 52.5 cm H(2)O and the mean RLPP was 43.1 cm H(2)O. After 3 months of HCl duloxetine treatment the mean ALPP was 59.1 cm H(2)O, the mean MUCP was 67.3 cm H(2)O and the mean RLPP was 45.1 cm H(2)O. There was a statistically significant correlation among RLPP, MUCP and ALPP before treatment. After HCl duloxetine treatment there was significant correlation between RLPP and ALPP. CONCLUSION: The use of HCl duloxetine results in mild increase of MUCP and in significant reduction of urine loss. Its action on the extrinsic sphincter does not provide a complete treatment option for postprostatectomy incontinence. SN - 0042-1138 UR - https://www.unboundmedicine.com/medline/citation/16825808/Is_HCl_duloxetine_effective_in_the_management_of_urinary_stress_incontinence_after_radical_prostatectomy L2 - https://www.karger.com?DOI=10.1159/000092927 DB - PRIME DP - Unbound Medicine ER -