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Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice.
Neurobiol Aging. 2007 Aug; 28(8):1248-57.NA

Abstract

To understand the relationship between amyloid-beta and cognitive decline in Alzheimer's disease, we evaluated cortical and hippocampal function in a transgenic mouse model of amyloid over-expression in Alzheimer's disease, the Tg2576 mouse. Tg2576 mice and their non-transgenic littermates were assessed at both 6 and 14 months of age in a battery of cognitive tests: attentional set-shifting, water maze spatial reference memory and T-maze working memory. Spatial reference memory was not affected by Tg status at either age. Working memory was only affected by age, with 6-month-old mice performing better than 14-month-old ones. Older mice were also significantly impaired on reversal learning and on the intra- and extra-dimensional shift in attentional set-shifting. A significant transgene effect was apparent in reversal learning, with Tg2576 mice requiring more trials to reach criterion at 6 months old. These data indicate that the effects of normal aging in C57B6xSJL F1 mice are most pronounced on putative frontal cortex-dependent tasks and that increasing Abeta load only affects discrimination reversal learning in our study.

Authors+Show Affiliations

College of Medicine, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA. zhuo.jiamin@mayo.edu <zhuo.jiamin@mayo.edu>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16828204

Citation

Zhuo, Jia-Min, et al. "Early Discrimination Reversal Learning Impairment and Preserved Spatial Learning in a Longitudinal Study of Tg2576 APPsw Mice." Neurobiology of Aging, vol. 28, no. 8, 2007, pp. 1248-57.
Zhuo JM, Prescott SL, Murray ME, et al. Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice. Neurobiol Aging. 2007;28(8):1248-57.
Zhuo, J. M., Prescott, S. L., Murray, M. E., Zhang, H. Y., Baxter, M. G., & Nicolle, M. M. (2007). Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice. Neurobiology of Aging, 28(8), 1248-57.
Zhuo JM, et al. Early Discrimination Reversal Learning Impairment and Preserved Spatial Learning in a Longitudinal Study of Tg2576 APPsw Mice. Neurobiol Aging. 2007;28(8):1248-57. PubMed PMID: 16828204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice. AU - Zhuo,Jia-Min, AU - Prescott,Sonya L, AU - Murray,Melissa E, AU - Zhang,Hai-Yan, AU - Baxter,Mark G, AU - Nicolle,Michelle M, Y1 - 2006/07/07/ PY - 2005/10/17/received PY - 2006/05/01/revised PY - 2006/05/30/accepted PY - 2006/7/11/pubmed PY - 2007/7/11/medline PY - 2006/7/11/entrez SP - 1248 EP - 57 JF - Neurobiology of aging JO - Neurobiol Aging VL - 28 IS - 8 N2 - To understand the relationship between amyloid-beta and cognitive decline in Alzheimer's disease, we evaluated cortical and hippocampal function in a transgenic mouse model of amyloid over-expression in Alzheimer's disease, the Tg2576 mouse. Tg2576 mice and their non-transgenic littermates were assessed at both 6 and 14 months of age in a battery of cognitive tests: attentional set-shifting, water maze spatial reference memory and T-maze working memory. Spatial reference memory was not affected by Tg status at either age. Working memory was only affected by age, with 6-month-old mice performing better than 14-month-old ones. Older mice were also significantly impaired on reversal learning and on the intra- and extra-dimensional shift in attentional set-shifting. A significant transgene effect was apparent in reversal learning, with Tg2576 mice requiring more trials to reach criterion at 6 months old. These data indicate that the effects of normal aging in C57B6xSJL F1 mice are most pronounced on putative frontal cortex-dependent tasks and that increasing Abeta load only affects discrimination reversal learning in our study. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/16828204/Early_discrimination_reversal_learning_impairment_and_preserved_spatial_learning_in_a_longitudinal_study_of_Tg2576_APPsw_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(06)00194-1 DB - PRIME DP - Unbound Medicine ER -