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Polyunsaturated fatty acids and inflammation.
Prostaglandins Leukot Essent Fatty Acids. 2006 Sep; 75(3):197-202.PL

Abstract

The n-6 polyunsaturated fatty acid arachidonic acid gives rise to the eicosanoid family of mediators (prostaglandins, thromboxanes, leukotrienes and related metabolites). These have inflammatory actions in their own right and also regulate the production of other mediators including inflammatory cytokines. Consumption of long chain n-3 polyunsaturated fatty acids decreases the amount of arachidonic acid in cell membranes and so available for eicosanoid production. Thus, n-3 polyunsaturated fatty acids decrease production of arachidonic acid-derived eicosanoids. These fatty acids also decrease the production of the classic inflammatory cytokines tumour necrosis factor, interleukin-1, and interleukin-6 and the expression of adhesion molecules involved in inflammatory interactions between leukocytes and endothelial cells. These latter effects may occur by eicosanoid-independent mechanisms including modulation of the activation of transcription factors involved in inflammatory processes. The anti-inflammatory actions of long chain n-3 fatty acid-induced effects may be of therapeutic use in conditions with an acute or chronic inflammatory component.

Authors+Show Affiliations

Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK. pcc@soton.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16828270

Citation

Calder, Philip C.. "Polyunsaturated Fatty Acids and Inflammation." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 75, no. 3, 2006, pp. 197-202.
Calder PC. Polyunsaturated fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids. 2006;75(3):197-202.
Calder, P. C. (2006). Polyunsaturated fatty acids and inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 75(3), 197-202.
Calder PC. Polyunsaturated Fatty Acids and Inflammation. Prostaglandins Leukot Essent Fatty Acids. 2006;75(3):197-202. PubMed PMID: 16828270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyunsaturated fatty acids and inflammation. A1 - Calder,Philip C, Y1 - 2006/07/07/ PY - 2006/7/11/pubmed PY - 2006/12/9/medline PY - 2006/7/11/entrez SP - 197 EP - 202 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 75 IS - 3 N2 - The n-6 polyunsaturated fatty acid arachidonic acid gives rise to the eicosanoid family of mediators (prostaglandins, thromboxanes, leukotrienes and related metabolites). These have inflammatory actions in their own right and also regulate the production of other mediators including inflammatory cytokines. Consumption of long chain n-3 polyunsaturated fatty acids decreases the amount of arachidonic acid in cell membranes and so available for eicosanoid production. Thus, n-3 polyunsaturated fatty acids decrease production of arachidonic acid-derived eicosanoids. These fatty acids also decrease the production of the classic inflammatory cytokines tumour necrosis factor, interleukin-1, and interleukin-6 and the expression of adhesion molecules involved in inflammatory interactions between leukocytes and endothelial cells. These latter effects may occur by eicosanoid-independent mechanisms including modulation of the activation of transcription factors involved in inflammatory processes. The anti-inflammatory actions of long chain n-3 fatty acid-induced effects may be of therapeutic use in conditions with an acute or chronic inflammatory component. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/16828270/Polyunsaturated_fatty_acids_and_inflammation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(06)00091-3 DB - PRIME DP - Unbound Medicine ER -