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Inhibition of tumor necrosis factor-alpha signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction.
Neurobiol Dis. 2006 Sep; 23(3):663-8.ND

Abstract

Our previous studies demonstrated that the psychostimulant methamphetamine (MA) and the human immunodeficiency virus-1 (HIV-1) protein Tat interacted to cause enhanced dopaminergic neurotoxicity. The present study examined whether tumor necrosis factor-alpha (TNF-alpha) mediates the interaction between Tat and MA. In Sprague-Dawley rats, injections of Tat caused a small but significant increase in striatal TNF-alpha level, whereas MA resulted in no change. The increase in TNF-alpha induced by Tat + MA was not significantly different from that induced by Tat alone. Temporal analysis of TNF-alpha levels revealed a 50-fold increase 4 h after Tat administration. In C57BL/6 mice, Tat + MA induced a 50% decline in striatal dopamine levels, which was significantly attenuated in mice lacking both receptors for TNF-alpha. TNF-alpha synthesis inhibitors significantly attenuated Tat + MA neurotoxicity in hippocampal neuronal culture. The results suggest that Tat-induced elevation of TNF-alpha may predispose the dopaminergic terminals to subsequent damage by MA.

Authors+Show Affiliations

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16828290

Citation

Theodore, Shaji, et al. "Inhibition of Tumor Necrosis Factor-alpha Signaling Prevents Human Immunodeficiency Virus-1 Protein Tat and Methamphetamine Interaction." Neurobiology of Disease, vol. 23, no. 3, 2006, pp. 663-8.
Theodore S, Cass WA, Nath A, et al. Inhibition of tumor necrosis factor-alpha signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction. Neurobiol Dis. 2006;23(3):663-8.
Theodore, S., Cass, W. A., Nath, A., Steiner, J., Young, K., & Maragos, W. F. (2006). Inhibition of tumor necrosis factor-alpha signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction. Neurobiology of Disease, 23(3), 663-8.
Theodore S, et al. Inhibition of Tumor Necrosis Factor-alpha Signaling Prevents Human Immunodeficiency Virus-1 Protein Tat and Methamphetamine Interaction. Neurobiol Dis. 2006;23(3):663-8. PubMed PMID: 16828290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of tumor necrosis factor-alpha signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction. AU - Theodore,Shaji, AU - Cass,Wayne A, AU - Nath,Avindra, AU - Steiner,Joseph, AU - Young,Kristie, AU - Maragos,William F, Y1 - 2006/07/07/ PY - 2006/01/17/received PY - 2006/04/25/revised PY - 2006/05/18/accepted PY - 2006/7/11/pubmed PY - 2006/11/2/medline PY - 2006/7/11/entrez SP - 663 EP - 8 JF - Neurobiology of disease JO - Neurobiol Dis VL - 23 IS - 3 N2 - Our previous studies demonstrated that the psychostimulant methamphetamine (MA) and the human immunodeficiency virus-1 (HIV-1) protein Tat interacted to cause enhanced dopaminergic neurotoxicity. The present study examined whether tumor necrosis factor-alpha (TNF-alpha) mediates the interaction between Tat and MA. In Sprague-Dawley rats, injections of Tat caused a small but significant increase in striatal TNF-alpha level, whereas MA resulted in no change. The increase in TNF-alpha induced by Tat + MA was not significantly different from that induced by Tat alone. Temporal analysis of TNF-alpha levels revealed a 50-fold increase 4 h after Tat administration. In C57BL/6 mice, Tat + MA induced a 50% decline in striatal dopamine levels, which was significantly attenuated in mice lacking both receptors for TNF-alpha. TNF-alpha synthesis inhibitors significantly attenuated Tat + MA neurotoxicity in hippocampal neuronal culture. The results suggest that Tat-induced elevation of TNF-alpha may predispose the dopaminergic terminals to subsequent damage by MA. SN - 0969-9961 UR - https://www.unboundmedicine.com/medline/citation/16828290/Inhibition_of_tumor_necrosis_factor_alpha_signaling_prevents_human_immunodeficiency_virus_1_protein_Tat_and_methamphetamine_interaction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0969-9961(06)00125-2 DB - PRIME DP - Unbound Medicine ER -