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Retinal vascular caliber and risk of retinopathy in young patients with type 1 diabetes.
Ophthalmology. 2006 Sep; 113(9):1499-503.O

Abstract

OBJECTIVE

To examine the relationship between retinal vascular caliber and incident retinopathy in children and adolescents with type 1 diabetes mellitus.

DESIGN

Hospital-based case-control study with prospective outcomes.

PARTICIPANTS

Cases and controls were selected from a cohort of children and adolescents 12 to 20 years old with type 1 diabetes followed up at a tertiary diabetes clinic. Cases were patients who developed incident diabetic retinopathy (n = 166) after at least 1 year of follow-up (> or =2 clinic visits), and controls were patients who had not developed retinopathy (n = 165) after > or =2 years of follow-up (> or =3 clinic visits). Baseline retinal photographs of cases and controls were digitized, and retinal vascular calibers were measured using a computer-assisted program by a grader masked to case-control status. These measurements were combined into summary indices reflecting the average arteriolar and venular calibers.

MAIN OUTCOME MEASURE

Development of diabetic retinopathy.

RESULTS

Incident retinopathy cases had retinal arteriolar calibers (mean +/- standard deviation [SD], 206.5+/-18.4 microm) significantly larger than those of controls (200.2+/-16.5 microm) (P = 0.004) but similar retinal venular calibers (329.1+/-14.7 microm in cases vs. 326.4+/-15.1 microm in controls, P = 0.312). After adjusting for age, gender, diabetes duration, glycated hemoglobin levels, blood pressure, body mass index, and pubertal stage, larger arteriolar caliber was predictive of risk of diabetic retinopathy (odds ratio, 1.44 per SD increase in arteriolar caliber; 95% confidence interval, 1.11-1.86).

CONCLUSION

Larger retinal arteriolar caliber predicts incident retinopathy in children and adolescents with type 1 diabetes, independent of conventional risk factors for retinopathy. Measurement of retinal vascular caliber may provide prognostic information regarding the subsequent risk of diabetic retinopathy.

Links

Publisher Full Text

Authors+Show Affiliations

Alibrahim E
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.
Donaghue KC
No affiliation info available
Rogers S
No affiliation info available
Hing S
No affiliation info available
Jenkins AJ
No affiliation info available
Chan A
No affiliation info available
Wong TY
No affiliation info available

MeSH

AdolescentAdultAnthropometryBlood PressureCase-Control StudiesChildDiabetes Mellitus, Type 1Diabetic RetinopathyFemaleFollow-Up StudiesGlycated Hemoglobin AHumansIncidenceMaleNew South WalesPhotographyProspective StudiesRetinal ArteryRetinal VeinRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16828499

Citation

Alibrahim, Ekaterina, et al. "Retinal Vascular Caliber and Risk of Retinopathy in Young Patients With Type 1 Diabetes." Ophthalmology, vol. 113, no. 9, 2006, pp. 1499-503.
Alibrahim E, Donaghue KC, Rogers S, et al. Retinal vascular caliber and risk of retinopathy in young patients with type 1 diabetes. Ophthalmology. 2006;113(9):1499-503.
Alibrahim, E., Donaghue, K. C., Rogers, S., Hing, S., Jenkins, A. J., Chan, A., & Wong, T. Y. (2006). Retinal vascular caliber and risk of retinopathy in young patients with type 1 diabetes. Ophthalmology, 113(9), 1499-503.
Alibrahim E, et al. Retinal Vascular Caliber and Risk of Retinopathy in Young Patients With Type 1 Diabetes. Ophthalmology. 2006;113(9):1499-503. PubMed PMID: 16828499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal vascular caliber and risk of retinopathy in young patients with type 1 diabetes. AU - Alibrahim,Ekaterina, AU - Donaghue,Kim C, AU - Rogers,Sophie, AU - Hing,Stephen, AU - Jenkins,Alicia J, AU - Chan,Albert, AU - Wong,Tien Y, Y1 - 2006/07/07/ PY - 2005/10/31/received PY - 2006/05/04/revised PY - 2006/05/04/accepted PY - 2006/7/11/pubmed PY - 2006/9/15/medline PY - 2006/7/11/entrez SP - 1499 EP - 503 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 9 N2 - OBJECTIVE: To examine the relationship between retinal vascular caliber and incident retinopathy in children and adolescents with type 1 diabetes mellitus. DESIGN: Hospital-based case-control study with prospective outcomes. PARTICIPANTS: Cases and controls were selected from a cohort of children and adolescents 12 to 20 years old with type 1 diabetes followed up at a tertiary diabetes clinic. Cases were patients who developed incident diabetic retinopathy (n = 166) after at least 1 year of follow-up (> or =2 clinic visits), and controls were patients who had not developed retinopathy (n = 165) after > or =2 years of follow-up (> or =3 clinic visits). Baseline retinal photographs of cases and controls were digitized, and retinal vascular calibers were measured using a computer-assisted program by a grader masked to case-control status. These measurements were combined into summary indices reflecting the average arteriolar and venular calibers. MAIN OUTCOME MEASURE: Development of diabetic retinopathy. RESULTS: Incident retinopathy cases had retinal arteriolar calibers (mean +/- standard deviation [SD], 206.5+/-18.4 microm) significantly larger than those of controls (200.2+/-16.5 microm) (P = 0.004) but similar retinal venular calibers (329.1+/-14.7 microm in cases vs. 326.4+/-15.1 microm in controls, P = 0.312). After adjusting for age, gender, diabetes duration, glycated hemoglobin levels, blood pressure, body mass index, and pubertal stage, larger arteriolar caliber was predictive of risk of diabetic retinopathy (odds ratio, 1.44 per SD increase in arteriolar caliber; 95% confidence interval, 1.11-1.86). CONCLUSION: Larger retinal arteriolar caliber predicts incident retinopathy in children and adolescents with type 1 diabetes, independent of conventional risk factors for retinopathy. Measurement of retinal vascular caliber may provide prognostic information regarding the subsequent risk of diabetic retinopathy. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16828499/Retinal_vascular_caliber_and_risk_of_retinopathy_in_young_patients_with_type_1_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00646-4 DB - PRIME DP - Unbound Medicine ER -