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Retinal vessel signs and 10-year incident age-related maculopathy: the Blue Mountains Eye Study.
Ophthalmology. 2006 Sep; 113(9):1481-7.O

Abstract

OBJECTIVE

To examine whether retinal vessel signs are independent predictors of the long-term development of age-related maculopathy (ARM).

DESIGN

Prospective population-based cohort study.

PARTICIPANTS

Blue Mountains Eye Study participants aged > or =49 years (n = 3654) were examined during 1992 through 1994; 2335 (75% of survivors) were reexamined after 5 years and 1952 (76% of survivors) were reexamined after 10 years.

METHODS

Baseline focal arteriolar narrowing and arteriovenous (AV) nicking were assessed and vessel calibers were measured from retinal photographs. A side-by-side grading method was used to assess ARM incidence. Eye-specific data were analyzed using generalized estimating equation models, adjusting for age, gender, smoking, and blood pressure.

MAIN OUTCOME MEASURES

Incident early ARM (soft indistinct or reticular drusen or combined soft distinct drusen and retinal pigment abnormality) was defined in eyes free of both early and late ARM at baseline. Incident late ARM (either geographic atrophy or neovascular macular degeneration) was defined in eyes free of these 2 lesions at baseline.

RESULTS

Over a 10-year period, incident late ARM developed in 106/4745 eyes at risk of late ARM (2.2%). Eyes with mild (2.7%) or severe (4.6 %) AV nicking were more likely to develop late ARM than eyes without this sign (1.5%). The adjusted odds ratio (OR) was 1.4, 95% confidence interval (CI) 0.8 to 2.4 for mild and OR 2.6, 95% CI 1.2 to 5.5 for severe AV nicking. Eyes with focal narrowing were also more likely to develop late ARM (7.6% vs. 1.8%), adjusted OR 2.2, 95% CI 1.1 to 4.1. Incident early ARM developed in 398/4490 eyes at risk of early ARM (8.9%). Severe AV nicking, but not focal arteriolar narrowing, was associated with an increased long-term risk of early ARM (13.6% vs. 8.2%; OR 1.5; 95% CI 1.0-2.3). Neither arteriolar nor venular caliber was significantly associated with the incidence of either early or late ARM.

CONCLUSIONS

These 10-year incidence data confirm our previous observation that structural retinal arteriolar changes may either contribute to ARM progression or share common pathologic pathways with ARM, independent of traditional vascular risk factors.

Authors+Show Affiliations

Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16828507

Citation

Liew, Gerald, et al. "Retinal Vessel Signs and 10-year Incident Age-related Maculopathy: the Blue Mountains Eye Study." Ophthalmology, vol. 113, no. 9, 2006, pp. 1481-7.
Liew G, Kaushik S, Rochtchina E, et al. Retinal vessel signs and 10-year incident age-related maculopathy: the Blue Mountains Eye Study. Ophthalmology. 2006;113(9):1481-7.
Liew, G., Kaushik, S., Rochtchina, E., Tan, A. G., Mitchell, P., & Wang, J. J. (2006). Retinal vessel signs and 10-year incident age-related maculopathy: the Blue Mountains Eye Study. Ophthalmology, 113(9), 1481-7.
Liew G, et al. Retinal Vessel Signs and 10-year Incident Age-related Maculopathy: the Blue Mountains Eye Study. Ophthalmology. 2006;113(9):1481-7. PubMed PMID: 16828507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal vessel signs and 10-year incident age-related maculopathy: the Blue Mountains Eye Study. AU - Liew,Gerald, AU - Kaushik,Shweta, AU - Rochtchina,Elena, AU - Tan,Ava G, AU - Mitchell,Paul, AU - Wang,Jie Jin, Y1 - 2006/07/07/ PY - 2005/08/16/received PY - 2006/03/08/revised PY - 2006/01/26/accepted PY - 2006/7/11/pubmed PY - 2006/9/15/medline PY - 2006/7/11/entrez SP - 1481 EP - 7 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 9 N2 - OBJECTIVE: To examine whether retinal vessel signs are independent predictors of the long-term development of age-related maculopathy (ARM). DESIGN: Prospective population-based cohort study. PARTICIPANTS: Blue Mountains Eye Study participants aged > or =49 years (n = 3654) were examined during 1992 through 1994; 2335 (75% of survivors) were reexamined after 5 years and 1952 (76% of survivors) were reexamined after 10 years. METHODS: Baseline focal arteriolar narrowing and arteriovenous (AV) nicking were assessed and vessel calibers were measured from retinal photographs. A side-by-side grading method was used to assess ARM incidence. Eye-specific data were analyzed using generalized estimating equation models, adjusting for age, gender, smoking, and blood pressure. MAIN OUTCOME MEASURES: Incident early ARM (soft indistinct or reticular drusen or combined soft distinct drusen and retinal pigment abnormality) was defined in eyes free of both early and late ARM at baseline. Incident late ARM (either geographic atrophy or neovascular macular degeneration) was defined in eyes free of these 2 lesions at baseline. RESULTS: Over a 10-year period, incident late ARM developed in 106/4745 eyes at risk of late ARM (2.2%). Eyes with mild (2.7%) or severe (4.6 %) AV nicking were more likely to develop late ARM than eyes without this sign (1.5%). The adjusted odds ratio (OR) was 1.4, 95% confidence interval (CI) 0.8 to 2.4 for mild and OR 2.6, 95% CI 1.2 to 5.5 for severe AV nicking. Eyes with focal narrowing were also more likely to develop late ARM (7.6% vs. 1.8%), adjusted OR 2.2, 95% CI 1.1 to 4.1. Incident early ARM developed in 398/4490 eyes at risk of early ARM (8.9%). Severe AV nicking, but not focal arteriolar narrowing, was associated with an increased long-term risk of early ARM (13.6% vs. 8.2%; OR 1.5; 95% CI 1.0-2.3). Neither arteriolar nor venular caliber was significantly associated with the incidence of either early or late ARM. CONCLUSIONS: These 10-year incidence data confirm our previous observation that structural retinal arteriolar changes may either contribute to ARM progression or share common pathologic pathways with ARM, independent of traditional vascular risk factors. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16828507/Retinal_vessel_signs_and_10_year_incident_age_related_maculopathy:_the_Blue_Mountains_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00541-0 DB - PRIME DP - Unbound Medicine ER -