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Retinal vascular caliber in persons with type 2 diabetes: the Wisconsin Epidemiological Study of Diabetic Retinopathy: XX.
Ophthalmology. 2006 Sep; 113(9):1488-98.O

Abstract

PURPOSE

To describe retinal vascular caliber and correlates in people with type 2 diabetes.

DESIGN

Population-based study.

PARTICIPANTS

Thirteen hundred seventy persons diagnosed to have diabetes at or after 30 years of age in an 11-county area in south central Wisconsin from 1980 to 1982.

METHODS

Retinal photographs of 7 standard fields were taken; light box grading was done to determine retinopathy severity. Computer-assisted grading was done from a digitized image of field 1 to determine the central retinal arteriolar equivalent (CRAE; arteriolar caliber) and central retinal venular equivalent (CRVE; venular caliber).

MAIN OUTCOME MEASURES

Retinal arteriolar and venular calibers.

RESULTS

In multivariable analyses in persons with panretinal photocoagulation excluded, while controlling for refractive error, CRAE was associated independently with age (per 10 years, beta = -2.0 microm), mean arterial blood pressure (BP) (per 10 mmHg, beta = -2.2 microm), smoking status (current vs. never smoked, beta = 5.6 microm), and intraocular pressure (IOP) (per 1 mmHg, beta = 0.2 microm). The CRVE was associated independently with age (per 10 years, beta = -2.5 microm), mean arterial BP (per 10 mmHg, beta = -2.1 microm), smoking status (current vs. never smoked, beta = 11.6 microm), pack-years smoked (per 10 pack-years, beta = 1.0 microm), body mass index (per kg/m2, beta = 0.3 mm), pulse rate (per 10 beats/minute, beta = 1.5 microm), retinopathy severity (per 1 level, beta = 1.05 microm), and IOP (per 10 mmHg, beta = -0.5 microm). Smaller CRAEs and CRVEs were found in eyes with panretinal photocoagulation treatment than in eyes without such treatment.

CONCLUSIONS

In persons with type 2 diabetes, variations in retinal vascular caliber are related to various systemic and ocular factors. Understanding these relationships may provide further insights into early retinal vascular changes in diabetes.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726-2336, USA. kleinr@epi.ophth.wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16828517

Citation

Klein, Ronald, et al. "Retinal Vascular Caliber in Persons With Type 2 Diabetes: the Wisconsin Epidemiological Study of Diabetic Retinopathy: XX." Ophthalmology, vol. 113, no. 9, 2006, pp. 1488-98.
Klein R, Klein BE, Moss SE, et al. Retinal vascular caliber in persons with type 2 diabetes: the Wisconsin Epidemiological Study of Diabetic Retinopathy: XX. Ophthalmology. 2006;113(9):1488-98.
Klein, R., Klein, B. E., Moss, S. E., Wong, T. Y., & Sharrett, A. R. (2006). Retinal vascular caliber in persons with type 2 diabetes: the Wisconsin Epidemiological Study of Diabetic Retinopathy: XX. Ophthalmology, 113(9), 1488-98.
Klein R, et al. Retinal Vascular Caliber in Persons With Type 2 Diabetes: the Wisconsin Epidemiological Study of Diabetic Retinopathy: XX. Ophthalmology. 2006;113(9):1488-98. PubMed PMID: 16828517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal vascular caliber in persons with type 2 diabetes: the Wisconsin Epidemiological Study of Diabetic Retinopathy: XX. AU - Klein,Ronald, AU - Klein,Barbara E K, AU - Moss,Scot E, AU - Wong,Tien Y, AU - Sharrett,A Richey, Y1 - 2006/07/07/ PY - 2005/10/14/received PY - 2006/03/14/revised PY - 2006/03/14/accepted PY - 2006/7/11/pubmed PY - 2006/9/15/medline PY - 2006/7/11/entrez SP - 1488 EP - 98 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 9 N2 - PURPOSE: To describe retinal vascular caliber and correlates in people with type 2 diabetes. DESIGN: Population-based study. PARTICIPANTS: Thirteen hundred seventy persons diagnosed to have diabetes at or after 30 years of age in an 11-county area in south central Wisconsin from 1980 to 1982. METHODS: Retinal photographs of 7 standard fields were taken; light box grading was done to determine retinopathy severity. Computer-assisted grading was done from a digitized image of field 1 to determine the central retinal arteriolar equivalent (CRAE; arteriolar caliber) and central retinal venular equivalent (CRVE; venular caliber). MAIN OUTCOME MEASURES: Retinal arteriolar and venular calibers. RESULTS: In multivariable analyses in persons with panretinal photocoagulation excluded, while controlling for refractive error, CRAE was associated independently with age (per 10 years, beta = -2.0 microm), mean arterial blood pressure (BP) (per 10 mmHg, beta = -2.2 microm), smoking status (current vs. never smoked, beta = 5.6 microm), and intraocular pressure (IOP) (per 1 mmHg, beta = 0.2 microm). The CRVE was associated independently with age (per 10 years, beta = -2.5 microm), mean arterial BP (per 10 mmHg, beta = -2.1 microm), smoking status (current vs. never smoked, beta = 11.6 microm), pack-years smoked (per 10 pack-years, beta = 1.0 microm), body mass index (per kg/m2, beta = 0.3 mm), pulse rate (per 10 beats/minute, beta = 1.5 microm), retinopathy severity (per 1 level, beta = 1.05 microm), and IOP (per 10 mmHg, beta = -0.5 microm). Smaller CRAEs and CRVEs were found in eyes with panretinal photocoagulation treatment than in eyes without such treatment. CONCLUSIONS: In persons with type 2 diabetes, variations in retinal vascular caliber are related to various systemic and ocular factors. Understanding these relationships may provide further insights into early retinal vascular changes in diabetes. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16828517/Retinal_vascular_caliber_in_persons_with_type_2_diabetes:_the_Wisconsin_Epidemiological_Study_of_Diabetic_Retinopathy:_XX_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00430-1 DB - PRIME DP - Unbound Medicine ER -