Tags

Type your tag names separated by a space and hit enter

Metabolism of alpha-linolenic acid in humans.

Abstract

Alpha-linolenic acid (18:3n-3) is essential in the human diet, probably because it is the substrate for the synthesis of longer-chain, more unsaturated n-3 fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) which are required for tissue function. This article reviews the recent literature on 18:3n-3 metabolism in humans, including fatty acid beta-oxidation, recycling of carbon by fatty acid synthesis de novo and conversion to longer-chain polyunsaturated fatty acids (PUFA). In men, stable isotope tracer studies and studies in which volunteers increased their consumption of 18:3n-3 show conversion to 20:5n-3 and 22:5n-3, but limited conversion to 22:6n-3. However, conversion to 18:3n-3 to 20:5n-3 and 22:6n-3 is greater in women compared to men, due possibly to a regulatory effect of oestrogen, while partitioning of 18:3n-3 towards beta-oxidation and carbon recycling was lower than in men. These gender differences may be an important consideration in making dietary recommendations for n-3 PUFA intake.

Authors+Show Affiliations

Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK. g.c.burdge@soton.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16828546

Citation

Burdge, G C.. "Metabolism of Alpha-linolenic Acid in Humans." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 75, no. 3, 2006, pp. 161-8.
Burdge GC. Metabolism of alpha-linolenic acid in humans. Prostaglandins Leukot Essent Fatty Acids. 2006;75(3):161-8.
Burdge, G. C. (2006). Metabolism of alpha-linolenic acid in humans. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 75(3), 161-8.
Burdge GC. Metabolism of Alpha-linolenic Acid in Humans. Prostaglandins Leukot Essent Fatty Acids. 2006;75(3):161-8. PubMed PMID: 16828546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolism of alpha-linolenic acid in humans. A1 - Burdge,G C, Y1 - 2006/07/07/ PY - 2006/7/11/pubmed PY - 2006/12/9/medline PY - 2006/7/11/entrez SP - 161 EP - 8 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 75 IS - 3 N2 - Alpha-linolenic acid (18:3n-3) is essential in the human diet, probably because it is the substrate for the synthesis of longer-chain, more unsaturated n-3 fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) which are required for tissue function. This article reviews the recent literature on 18:3n-3 metabolism in humans, including fatty acid beta-oxidation, recycling of carbon by fatty acid synthesis de novo and conversion to longer-chain polyunsaturated fatty acids (PUFA). In men, stable isotope tracer studies and studies in which volunteers increased their consumption of 18:3n-3 show conversion to 20:5n-3 and 22:5n-3, but limited conversion to 22:6n-3. However, conversion to 18:3n-3 to 20:5n-3 and 22:6n-3 is greater in women compared to men, due possibly to a regulatory effect of oestrogen, while partitioning of 18:3n-3 towards beta-oxidation and carbon recycling was lower than in men. These gender differences may be an important consideration in making dietary recommendations for n-3 PUFA intake. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/16828546/Metabolism_of_alpha_linolenic_acid_in_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(06)00083-4 DB - PRIME DP - Unbound Medicine ER -