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Comparison of results of percutaneous coronary intervention for non-ST-elevation acute myocardial infarction or unstable angina pectoris in men versus women.
Am J Cardiol 2006; 98(2):182-6AJ

Abstract

Previous randomized trials have addressed the impact of gender on outcomes, showing worse results in women assigned to invasive strategies compared with men with non-ST-elevation (NSTE) acute coronary syndrome (ACS). However, there is still a significant amount of controversy on strategies of treatment on the basis of gender. This study evaluated the impact of gender on treatment strategies and outcomes in patients with NSTE ACS in a high-volume, single-site tertiary center. We identified 1,197 consecutive patients with NSTE ACS (381 women, 816 men) who underwent percutaneous coronary intervention during their index hospitalizations. Patients were stratified by gender and baseline clinical and angiographic characteristics, and in-hospital and 9-month clinical outcomes were compared between the 2 groups. There were clear differences in baseline characteristics between men and women with ACS at presentation. Women were, on average, slightly older than men, with more hypertension and morbid obesity, but there were no differences in racial backgrounds or the prevalence of diabetes or dyslipidemia, nor were there treatment disparities in pharmacologic interventions. Women and men with ACS had similar rates of percutaneous coronary intervention on index admission. Women had a greater incidence of bleeding complications requiring blood transfusions. Overall, in-hospital and 9-month event-free survival were equivalent for the 2 genders. In conclusion, in this single-site observational study, patients with NSTE ACS who underwent angiography followed by percutaneous coronary intervention demonstrated no significant gender differences in treatment or in-hospital or 9-month event-free survival. From these results, interventional strategies should not be based on gender.

Authors+Show Affiliations

Division of Cardiology, The Henry Low Heart Center, Hartford Hospital, Hartford, and University of Connecticut School of Medicine, Farmington, USA. relkous@harthosp.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16828589

Citation

Elkoustaf, Rachid A., et al. "Comparison of Results of Percutaneous Coronary Intervention for non-ST-elevation Acute Myocardial Infarction or Unstable Angina Pectoris in Men Versus Women." The American Journal of Cardiology, vol. 98, no. 2, 2006, pp. 182-6.
Elkoustaf RA, Mamkin I, Mather JF, et al. Comparison of results of percutaneous coronary intervention for non-ST-elevation acute myocardial infarction or unstable angina pectoris in men versus women. Am J Cardiol. 2006;98(2):182-6.
Elkoustaf, R. A., Mamkin, I., Mather, J. F., Murphy, D., Hirst, J. A., Kiernan, F. J., & McKay, R. G. (2006). Comparison of results of percutaneous coronary intervention for non-ST-elevation acute myocardial infarction or unstable angina pectoris in men versus women. The American Journal of Cardiology, 98(2), pp. 182-6.
Elkoustaf RA, et al. Comparison of Results of Percutaneous Coronary Intervention for non-ST-elevation Acute Myocardial Infarction or Unstable Angina Pectoris in Men Versus Women. Am J Cardiol. 2006 Jul 15;98(2):182-6. PubMed PMID: 16828589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of results of percutaneous coronary intervention for non-ST-elevation acute myocardial infarction or unstable angina pectoris in men versus women. AU - Elkoustaf,Rachid A, AU - Mamkin,Igor, AU - Mather,Jeff F, AU - Murphy,Deborah, AU - Hirst,Jeffrey A, AU - Kiernan,Francis J, AU - McKay,Raymond G, Y1 - 2006/05/19/ PY - 2005/08/18/received PY - 2006/01/19/revised PY - 2006/01/19/accepted PY - 2006/7/11/pubmed PY - 2006/8/19/medline PY - 2006/7/11/entrez SP - 182 EP - 6 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 98 IS - 2 N2 - Previous randomized trials have addressed the impact of gender on outcomes, showing worse results in women assigned to invasive strategies compared with men with non-ST-elevation (NSTE) acute coronary syndrome (ACS). However, there is still a significant amount of controversy on strategies of treatment on the basis of gender. This study evaluated the impact of gender on treatment strategies and outcomes in patients with NSTE ACS in a high-volume, single-site tertiary center. We identified 1,197 consecutive patients with NSTE ACS (381 women, 816 men) who underwent percutaneous coronary intervention during their index hospitalizations. Patients were stratified by gender and baseline clinical and angiographic characteristics, and in-hospital and 9-month clinical outcomes were compared between the 2 groups. There were clear differences in baseline characteristics between men and women with ACS at presentation. Women were, on average, slightly older than men, with more hypertension and morbid obesity, but there were no differences in racial backgrounds or the prevalence of diabetes or dyslipidemia, nor were there treatment disparities in pharmacologic interventions. Women and men with ACS had similar rates of percutaneous coronary intervention on index admission. Women had a greater incidence of bleeding complications requiring blood transfusions. Overall, in-hospital and 9-month event-free survival were equivalent for the 2 genders. In conclusion, in this single-site observational study, patients with NSTE ACS who underwent angiography followed by percutaneous coronary intervention demonstrated no significant gender differences in treatment or in-hospital or 9-month event-free survival. From these results, interventional strategies should not be based on gender. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/16828589/Comparison_of_results_of_percutaneous_coronary_intervention_for_non_ST_elevation_acute_myocardial_infarction_or_unstable_angina_pectoris_in_men_versus_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(06)00663-1 DB - PRIME DP - Unbound Medicine ER -