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Treatment of depression in patients with coronary heart disease.
Am J Med. 2006 Jul; 119(7):567-73.AJ

Abstract

Depression and coronary heart disease are common conditions that often occur together. Evidence shows that the co-occurrence of these illnesses is not random but driven by depression as a risk factor for the occurrence and progression of coronary heart disease. This link is due, in part, to the impact that depression has on neuroendocrine pathways leading to increased platelet activation, cortisol and catecholamine excess, and altered autonomic nervous system function that influence the pathogenesis and progression of coronary atherosclerosis and subsequent heart disease. We know that treating depression in patients with coronary heart disease improves the symptoms and signs of depression. Evidence is less compelling that treating depression improves the morbidity and mortality of coronary heart disease. However, early findings suggest that some antidepressants may improve the course of coronary heart disease and improve patient compliance with various cardiac interventions. We outline a practical approach to the treatment of depression in patients with coronary heart disease. This approach includes education, counseling, antidepressant drugs, and referral when appropriate.

Authors+Show Affiliations

Psychiatry Services, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, USA. vvieweg@visi.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16828625

Citation

Vieweg, W Victor R., et al. "Treatment of Depression in Patients With Coronary Heart Disease." The American Journal of Medicine, vol. 119, no. 7, 2006, pp. 567-73.
Vieweg WV, Julius DA, Fernandez A, et al. Treatment of depression in patients with coronary heart disease. Am J Med. 2006;119(7):567-73.
Vieweg, W. V., Julius, D. A., Fernandez, A., Wulsin, L. R., Mohanty, P. K., Beatty-Brooks, M., Hasnain, M., & Pandurangi, A. K. (2006). Treatment of depression in patients with coronary heart disease. The American Journal of Medicine, 119(7), 567-73.
Vieweg WV, et al. Treatment of Depression in Patients With Coronary Heart Disease. Am J Med. 2006;119(7):567-73. PubMed PMID: 16828625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of depression in patients with coronary heart disease. AU - Vieweg,W Victor R, AU - Julius,Demetrios A, AU - Fernandez,Antony, AU - Wulsin,Lawson R, AU - Mohanty,Pramod K, AU - Beatty-Brooks,Mary, AU - Hasnain,Mehrul, AU - Pandurangi,Anand K, PY - 2006/02/20/received PY - 2006/02/21/accepted PY - 2006/7/11/pubmed PY - 2006/7/14/medline PY - 2006/7/11/entrez SP - 567 EP - 73 JF - The American journal of medicine JO - Am J Med VL - 119 IS - 7 N2 - Depression and coronary heart disease are common conditions that often occur together. Evidence shows that the co-occurrence of these illnesses is not random but driven by depression as a risk factor for the occurrence and progression of coronary heart disease. This link is due, in part, to the impact that depression has on neuroendocrine pathways leading to increased platelet activation, cortisol and catecholamine excess, and altered autonomic nervous system function that influence the pathogenesis and progression of coronary atherosclerosis and subsequent heart disease. We know that treating depression in patients with coronary heart disease improves the symptoms and signs of depression. Evidence is less compelling that treating depression improves the morbidity and mortality of coronary heart disease. However, early findings suggest that some antidepressants may improve the course of coronary heart disease and improve patient compliance with various cardiac interventions. We outline a practical approach to the treatment of depression in patients with coronary heart disease. This approach includes education, counseling, antidepressant drugs, and referral when appropriate. SN - 1555-7162 UR - https://www.unboundmedicine.com/medline/citation/16828625/Treatment_of_depression_in_patients_with_coronary_heart_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(06)00334-2 DB - PRIME DP - Unbound Medicine ER -