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Histaminergic receptors of medial septum and conditioned place preference: D1 dopamine receptor mechanism.
Brain Res. 2006 Sep 13; 1109(1):108-16.BR

Abstract

In the present study, the effects of intra-medial septum injections of histamine and/or the histamine H1 or H2 receptor antagonists on the acquisition of conditioned place preference (CPP) in male Wistar rats have been investigated. Our data showed that the conditioning treatments with intra-medial septum injection of different doses of histamine (0.5-15 microg/rat) induced a significant CPP for the drug-associated place. Using a 3-day schedule of conditioning, it was found that the histamine H1 receptor antagonist, pyrilamine (10 and 15 microg/rat, intra-medial septum) also induced a significant place preference. In addition, pyrilamine inhibited the histamine (7.5 microg/rat)-induced place preference. Intra-medial septum administration of the histamine H2 receptor antagonist, ranitidine (5-15 microg/rat) alone or in combination with histamine did not produce a significant place preference or place aversion. On the other hand, intra-medial septum administration of the dopamine D1 receptor antagonist, SCH 233390 (0.5, 0.75 and 1 microg/rat) inhibited the histamine (7.5 microg/rat) or pyrilamine (15 microg/rat)-induced place preference in a dose-dependent manner, but no effect was observed for the dopamine D2 receptor antagonist, sulpiride on the histamine or pyrilamine response. The administration of histamine (2.5-15 microg/rat) or pyrilamine (10 and 15 microg/rat) during acquisition increased locomotor activity of the animals on the testing days. The results suggest that histaminergic receptors of the medial septum may be involved in CPP and thus it is postulated that dopamine D1 receptors may play an important role in this effect.

Authors+Show Affiliations

Department of Pharmacology and Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, PO Box 13145-784, Tehran, Iran. zarinmr@ams.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16828718

Citation

Zarrindast, Mohammad-Reza, et al. "Histaminergic Receptors of Medial Septum and Conditioned Place Preference: D1 Dopamine Receptor Mechanism." Brain Research, vol. 1109, no. 1, 2006, pp. 108-16.
Zarrindast MR, Moghimi M, Rostami P, et al. Histaminergic receptors of medial septum and conditioned place preference: D1 dopamine receptor mechanism. Brain Res. 2006;1109(1):108-16.
Zarrindast, M. R., Moghimi, M., Rostami, P., & Rezayof, A. (2006). Histaminergic receptors of medial septum and conditioned place preference: D1 dopamine receptor mechanism. Brain Research, 1109(1), 108-16.
Zarrindast MR, et al. Histaminergic Receptors of Medial Septum and Conditioned Place Preference: D1 Dopamine Receptor Mechanism. Brain Res. 2006 Sep 13;1109(1):108-16. PubMed PMID: 16828718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histaminergic receptors of medial septum and conditioned place preference: D1 dopamine receptor mechanism. AU - Zarrindast,Mohammad-Reza, AU - Moghimi,Maryam, AU - Rostami,Parvin, AU - Rezayof,Ameneh, Y1 - 2006/07/10/ PY - 2005/12/24/received PY - 2006/06/06/revised PY - 2006/06/12/accepted PY - 2006/7/11/pubmed PY - 2006/11/1/medline PY - 2006/7/11/entrez SP - 108 EP - 16 JF - Brain research JO - Brain Res VL - 1109 IS - 1 N2 - In the present study, the effects of intra-medial septum injections of histamine and/or the histamine H1 or H2 receptor antagonists on the acquisition of conditioned place preference (CPP) in male Wistar rats have been investigated. Our data showed that the conditioning treatments with intra-medial septum injection of different doses of histamine (0.5-15 microg/rat) induced a significant CPP for the drug-associated place. Using a 3-day schedule of conditioning, it was found that the histamine H1 receptor antagonist, pyrilamine (10 and 15 microg/rat, intra-medial septum) also induced a significant place preference. In addition, pyrilamine inhibited the histamine (7.5 microg/rat)-induced place preference. Intra-medial septum administration of the histamine H2 receptor antagonist, ranitidine (5-15 microg/rat) alone or in combination with histamine did not produce a significant place preference or place aversion. On the other hand, intra-medial septum administration of the dopamine D1 receptor antagonist, SCH 233390 (0.5, 0.75 and 1 microg/rat) inhibited the histamine (7.5 microg/rat) or pyrilamine (15 microg/rat)-induced place preference in a dose-dependent manner, but no effect was observed for the dopamine D2 receptor antagonist, sulpiride on the histamine or pyrilamine response. The administration of histamine (2.5-15 microg/rat) or pyrilamine (10 and 15 microg/rat) during acquisition increased locomotor activity of the animals on the testing days. The results suggest that histaminergic receptors of the medial septum may be involved in CPP and thus it is postulated that dopamine D1 receptors may play an important role in this effect. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/16828718/Histaminergic_receptors_of_medial_septum_and_conditioned_place_preference:_D1_dopamine_receptor_mechanism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(06)01791-4 DB - PRIME DP - Unbound Medicine ER -