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An influenza A/H3 outbreak during the 2004/2005 winter in elderly vaccinated people living in a nursing home.
Vaccine 2006; 24(44-46):6615-9V

Abstract

This study examined the antibody response against the three vaccine antigens and the epidemic A/H3N2 drift variant (A/California) and the prevention of laboratory diagnosed influenza infections in a group of elderly institutionalized people vaccinated with the 2004/2005 influenza vaccine. Antibody titres were measured by hemagglutination inhibition (HI) in sera collected before and 1 month after vaccination. Laboratory diagnosis was done examining throat swabs (RT-PCR or MDCK cell culture) or by serology (seroconversion comparing HI titres in sera collected 1 and 5 months after vaccination). Results obtained showed that influenza vaccination induced an adequate immune response against the three vaccine antigens and the epidemic A/H3N2 variant, however it was not capable of preventing an influenza outbreak due to the new A/H3N2 (A/California) variant.

Authors+Show Affiliations

Department of Hygiene, University of Perugia, Via del Giochetto, I-06100 Perugia, Italy. anna@unipg.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16828941

Citation

Iorio, A M., et al. "An Influenza A/H3 Outbreak During the 2004/2005 Winter in Elderly Vaccinated People Living in a Nursing Home." Vaccine, vol. 24, no. 44-46, 2006, pp. 6615-9.
Iorio AM, Neri M, Lepri E, et al. An influenza A/H3 outbreak during the 2004/2005 winter in elderly vaccinated people living in a nursing home. Vaccine. 2006;24(44-46):6615-9.
Iorio, A. M., Neri, M., Lepri, E., Camilloni, B., Basileo, M., Sigismondi, N., ... Donatelli, I. (2006). An influenza A/H3 outbreak during the 2004/2005 winter in elderly vaccinated people living in a nursing home. Vaccine, 24(44-46), pp. 6615-9.
Iorio AM, et al. An Influenza A/H3 Outbreak During the 2004/2005 Winter in Elderly Vaccinated People Living in a Nursing Home. Vaccine. 2006 Nov 10;24(44-46):6615-9. PubMed PMID: 16828941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An influenza A/H3 outbreak during the 2004/2005 winter in elderly vaccinated people living in a nursing home. AU - Iorio,A M, AU - Neri,M, AU - Lepri,E, AU - Camilloni,B, AU - Basileo,M, AU - Sigismondi,N, AU - Fabiani,C, AU - Calzoletti,L, AU - Puzelli,S, AU - Donatelli,I, Y1 - 2006/06/05/ PY - 2006/7/11/pubmed PY - 2007/1/24/medline PY - 2006/7/11/entrez SP - 6615 EP - 9 JF - Vaccine JO - Vaccine VL - 24 IS - 44-46 N2 - This study examined the antibody response against the three vaccine antigens and the epidemic A/H3N2 drift variant (A/California) and the prevention of laboratory diagnosed influenza infections in a group of elderly institutionalized people vaccinated with the 2004/2005 influenza vaccine. Antibody titres were measured by hemagglutination inhibition (HI) in sera collected before and 1 month after vaccination. Laboratory diagnosis was done examining throat swabs (RT-PCR or MDCK cell culture) or by serology (seroconversion comparing HI titres in sera collected 1 and 5 months after vaccination). Results obtained showed that influenza vaccination induced an adequate immune response against the three vaccine antigens and the epidemic A/H3N2 variant, however it was not capable of preventing an influenza outbreak due to the new A/H3N2 (A/California) variant. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/16828941/An_influenza_A/H3_outbreak_during_the_2004/2005_winter_in_elderly_vaccinated_people_living_in_a_nursing_home_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(06)00615-3 DB - PRIME DP - Unbound Medicine ER -