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An influenza A/H3 outbreak during the 2004/2005 winter in elderly vaccinated people living in a nursing home.

Abstract

This study examined the antibody response against the three vaccine antigens and the epidemic A/H3N2 drift variant (A/California) and the prevention of laboratory diagnosed influenza infections in a group of elderly institutionalized people vaccinated with the 2004/2005 influenza vaccine. Antibody titres were measured by hemagglutination inhibition (HI) in sera collected before and 1 month after vaccination. Laboratory diagnosis was done examining throat swabs (RT-PCR or MDCK cell culture) or by serology (seroconversion comparing HI titres in sera collected 1 and 5 months after vaccination). Results obtained showed that influenza vaccination induced an adequate immune response against the three vaccine antigens and the epidemic A/H3N2 variant, however it was not capable of preventing an influenza outbreak due to the new A/H3N2 (A/California) variant.

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  • Authors+Show Affiliations

    ,

    Department of Hygiene, University of Perugia, Via del Giochetto, I-06100 Perugia, Italy. anna@unipg.it

    , , , , , , , ,

    Source

    Vaccine 24:44-46 2006 Nov 10 pg 6615-9

    MeSH

    Aged
    Aged, 80 and over
    Antibodies, Viral
    Disease Outbreaks
    Hemagglutination Inhibition Tests
    Humans
    Influenza A Virus, H3N2 Subtype
    Influenza Vaccines
    Influenza, Human
    Nursing Homes
    Vaccination

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16828941

    Citation

    Iorio, A M., et al. "An Influenza A/H3 Outbreak During the 2004/2005 Winter in Elderly Vaccinated People Living in a Nursing Home." Vaccine, vol. 24, no. 44-46, 2006, pp. 6615-9.
    Iorio AM, Neri M, Lepri E, et al. An influenza A/H3 outbreak during the 2004/2005 winter in elderly vaccinated people living in a nursing home. Vaccine. 2006;24(44-46):6615-9.
    Iorio, A. M., Neri, M., Lepri, E., Camilloni, B., Basileo, M., Sigismondi, N., ... Donatelli, I. (2006). An influenza A/H3 outbreak during the 2004/2005 winter in elderly vaccinated people living in a nursing home. Vaccine, 24(44-46), pp. 6615-9.
    Iorio AM, et al. An Influenza A/H3 Outbreak During the 2004/2005 Winter in Elderly Vaccinated People Living in a Nursing Home. Vaccine. 2006 Nov 10;24(44-46):6615-9. PubMed PMID: 16828941.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - An influenza A/H3 outbreak during the 2004/2005 winter in elderly vaccinated people living in a nursing home. AU - Iorio,A M, AU - Neri,M, AU - Lepri,E, AU - Camilloni,B, AU - Basileo,M, AU - Sigismondi,N, AU - Fabiani,C, AU - Calzoletti,L, AU - Puzelli,S, AU - Donatelli,I, Y1 - 2006/06/05/ PY - 2006/7/11/pubmed PY - 2007/1/24/medline PY - 2006/7/11/entrez SP - 6615 EP - 9 JF - Vaccine JO - Vaccine VL - 24 IS - 44-46 N2 - This study examined the antibody response against the three vaccine antigens and the epidemic A/H3N2 drift variant (A/California) and the prevention of laboratory diagnosed influenza infections in a group of elderly institutionalized people vaccinated with the 2004/2005 influenza vaccine. Antibody titres were measured by hemagglutination inhibition (HI) in sera collected before and 1 month after vaccination. Laboratory diagnosis was done examining throat swabs (RT-PCR or MDCK cell culture) or by serology (seroconversion comparing HI titres in sera collected 1 and 5 months after vaccination). Results obtained showed that influenza vaccination induced an adequate immune response against the three vaccine antigens and the epidemic A/H3N2 variant, however it was not capable of preventing an influenza outbreak due to the new A/H3N2 (A/California) variant. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/16828941/An_influenza_A/H3_outbreak_during_the_2004/2005_winter_in_elderly_vaccinated_people_living_in_a_nursing_home_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(06)00615-3 DB - PRIME DP - Unbound Medicine ER -