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Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice.
Neurobiol Dis 2006; 23(3):653-62ND

Abstract

The deposition of amyloid beta (Abeta) peptides and neurofibrillary tangles are the two characteristic pathological features of Alzheimer's disease (AD). To investigate the relation between amyloid precursor protein (APP) production, amyloid beta deposition and the type of Abeta in deposits, i.e., human and/or mouse, we performed a histopathological analysis, using mouse and human specific antibodies, of the neocortex and hippocampus in 6, 12 and 19 months old APP/PS1 double and APP and PS1 single transgenic mice. There was a significant correlation between the human amyloid beta deposits and the intrinsic rodent amyloid beta deposits, that is, all plaques contained both human and mouse Abeta, and the diffuse amyloid beta deposits also colocalized human and mouse Abeta. Furthermore, some blood vessels (mainly leptomeningeal vessels) show labeling with human Abeta, and most of these vessels also label with mouse Abeta. Our findings demonstrate that the human amyloid deposits in APP/PS1 transgenic mice are closely associated with mouse Abeta, however, they do not precisely overlap. For instance, the core of plaques consists of primarily human Abeta, whereas the rim of the plaque contains both human and mouse amyloid beta, similarly, human and mouse Abeta are differentially localized in the blood vessel wall. Finally, as early as amyloid beta deposits can be detected, they show the presence of both human and mouse Abeta. Together, these data indicate that mouse Abeta is formed and deposited in significant amounts in the AD mouse brain and that it is deposited together with the human Abeta.

Authors+Show Affiliations

Department of Neuroscience and Neurology, University of Kuopio, Finland. vangroen@uab.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16829076

Citation

van Groen, Thomas, et al. "Deposition of Mouse Amyloid Beta in Human APP/PS1 Double and Single AD Model Transgenic Mice." Neurobiology of Disease, vol. 23, no. 3, 2006, pp. 653-62.
van Groen T, Kiliaan AJ, Kadish I. Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice. Neurobiol Dis. 2006;23(3):653-62.
van Groen, T., Kiliaan, A. J., & Kadish, I. (2006). Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice. Neurobiology of Disease, 23(3), pp. 653-62.
van Groen T, Kiliaan AJ, Kadish I. Deposition of Mouse Amyloid Beta in Human APP/PS1 Double and Single AD Model Transgenic Mice. Neurobiol Dis. 2006;23(3):653-62. PubMed PMID: 16829076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice. AU - van Groen,Thomas, AU - Kiliaan,Amanda J, AU - Kadish,Inga, Y1 - 2006/07/10/ PY - 2006/02/21/received PY - 2006/05/09/revised PY - 2006/05/18/accepted PY - 2006/7/11/pubmed PY - 2006/11/2/medline PY - 2006/7/11/entrez SP - 653 EP - 62 JF - Neurobiology of disease JO - Neurobiol. Dis. VL - 23 IS - 3 N2 - The deposition of amyloid beta (Abeta) peptides and neurofibrillary tangles are the two characteristic pathological features of Alzheimer's disease (AD). To investigate the relation between amyloid precursor protein (APP) production, amyloid beta deposition and the type of Abeta in deposits, i.e., human and/or mouse, we performed a histopathological analysis, using mouse and human specific antibodies, of the neocortex and hippocampus in 6, 12 and 19 months old APP/PS1 double and APP and PS1 single transgenic mice. There was a significant correlation between the human amyloid beta deposits and the intrinsic rodent amyloid beta deposits, that is, all plaques contained both human and mouse Abeta, and the diffuse amyloid beta deposits also colocalized human and mouse Abeta. Furthermore, some blood vessels (mainly leptomeningeal vessels) show labeling with human Abeta, and most of these vessels also label with mouse Abeta. Our findings demonstrate that the human amyloid deposits in APP/PS1 transgenic mice are closely associated with mouse Abeta, however, they do not precisely overlap. For instance, the core of plaques consists of primarily human Abeta, whereas the rim of the plaque contains both human and mouse amyloid beta, similarly, human and mouse Abeta are differentially localized in the blood vessel wall. Finally, as early as amyloid beta deposits can be detected, they show the presence of both human and mouse Abeta. Together, these data indicate that mouse Abeta is formed and deposited in significant amounts in the AD mouse brain and that it is deposited together with the human Abeta. SN - 0969-9961 UR - https://www.unboundmedicine.com/medline/citation/16829076/Deposition_of_mouse_amyloid_beta_in_human_APP/PS1_double_and_single_AD_model_transgenic_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0969-9961(06)00124-0 DB - PRIME DP - Unbound Medicine ER -