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Prevention of 5-fluorouracil-related stomatitis by oral cryotherapy: a randomized controlled study.
Eur J Oncol Nurs. 2007 Feb; 11(1):60-5.EJ

Abstract

Stomatitis is a common adverse effect of intravenously infused 5-fluorouracil (5FU). Although there are encouraging studies about the preventive role of oral cryotherapy in stomatitis induced by intravenous administration of 5FU, this simple and cost-effective method is not part of clinical practice. This prospective randomized study investigates whether oral cryotherapy alleviates 5FU-induced stomatitis. Thirty six patients, included in the cryotherapy group, were instructed to hold ice cubes in their oral cavity, shortly before, during and shortly after the infusion of 5FU. Both mean physician and patient-graded stomatitis of our cryotherapy group were compared with those of a control group (40 patients) and were found significantly reduced for all three chemotherapy cycles. The percentage of patients who were free from oral toxicity was significantly higher in the cryotherapy group in all three chemotherapy cycles, as judged both by patients and physicians. The results of this study encourage the use of cryotherapy in patients receiving 5FU in alleviating stomatitis by using a side-effect-free, easy to perform and inexpensive measure, which does not interfere with the efficacy of antineoplastic agents.

Authors+Show Affiliations

ENT Department, University Hospital of Patras, 26500 Rio Patras, Greece. evapapadeas@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16829196

Citation

Papadeas, E, et al. "Prevention of 5-fluorouracil-related Stomatitis By Oral Cryotherapy: a Randomized Controlled Study." European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society, vol. 11, no. 1, 2007, pp. 60-5.
Papadeas E, Naxakis S, Riga M, et al. Prevention of 5-fluorouracil-related stomatitis by oral cryotherapy: a randomized controlled study. Eur J Oncol Nurs. 2007;11(1):60-5.
Papadeas, E., Naxakis, S., Riga, M., & Kalofonos, C. h. (2007). Prevention of 5-fluorouracil-related stomatitis by oral cryotherapy: a randomized controlled study. European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society, 11(1), 60-5.
Papadeas E, et al. Prevention of 5-fluorouracil-related Stomatitis By Oral Cryotherapy: a Randomized Controlled Study. Eur J Oncol Nurs. 2007;11(1):60-5. PubMed PMID: 16829196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of 5-fluorouracil-related stomatitis by oral cryotherapy: a randomized controlled study. AU - Papadeas,E, AU - Naxakis,S, AU - Riga,M, AU - Kalofonos,Ch, Y1 - 2006/07/07/ PY - 2005/11/06/received PY - 2006/04/28/revised PY - 2006/05/05/accepted PY - 2006/7/11/pubmed PY - 2007/4/27/medline PY - 2006/7/11/entrez SP - 60 EP - 5 JF - European journal of oncology nursing : the official journal of European Oncology Nursing Society JO - Eur J Oncol Nurs VL - 11 IS - 1 N2 - Stomatitis is a common adverse effect of intravenously infused 5-fluorouracil (5FU). Although there are encouraging studies about the preventive role of oral cryotherapy in stomatitis induced by intravenous administration of 5FU, this simple and cost-effective method is not part of clinical practice. This prospective randomized study investigates whether oral cryotherapy alleviates 5FU-induced stomatitis. Thirty six patients, included in the cryotherapy group, were instructed to hold ice cubes in their oral cavity, shortly before, during and shortly after the infusion of 5FU. Both mean physician and patient-graded stomatitis of our cryotherapy group were compared with those of a control group (40 patients) and were found significantly reduced for all three chemotherapy cycles. The percentage of patients who were free from oral toxicity was significantly higher in the cryotherapy group in all three chemotherapy cycles, as judged both by patients and physicians. The results of this study encourage the use of cryotherapy in patients receiving 5FU in alleviating stomatitis by using a side-effect-free, easy to perform and inexpensive measure, which does not interfere with the efficacy of antineoplastic agents. SN - 1462-3889 UR - https://www.unboundmedicine.com/medline/citation/16829196/Prevention_of_5_fluorouracil_related_stomatitis_by_oral_cryotherapy:_a_randomized_controlled_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1462-3889(06)00111-6 DB - PRIME DP - Unbound Medicine ER -