Tags

Type your tag names separated by a space and hit enter

Recombinant human thyroid-stimulating hormone is effective for radioiodine ablation of post-surgical thyroid remnants.
Nucl Med Commun 2006; 27(8):627-32NM

Abstract

OBJECTIVE

To investigate whether recombinant human thyroid-stimulating factor (rhTSH) is effective for the radiometabolic ablation of post-surgery thyroid remnants, using low doses of (131)I.

PATIENTS AND METHODS

The study included two groups of patients enrolled consecutively: group 1 consisted of 52 patients with papillary cancer or minimally invasive follicular cancer (stage I and II), and group 2 consisted of 41 patients with the same stage of disease. All patients underwent a total thyroidectomy. Group 1 received 1.11 GBq (30 mCi) (131)I for post-surgical remnants ablation with the aid of rhTSH, while group 2, in the hypothyroid state, received the same amount of radioiodine. To minimize iodine interference, all patients remained on a low iodine diet for 2 weeks and L-thyroxine (L-T4) was stopped for 4 days in the group of patients treated with the aid of rhTSH. To investigate (131)I uptake in this group, a tracer dose was administered 3 h after the second injection of rhTSH and the uptake was evaluated at 24 h just before administration of the therapeutic dose. I was also measured in the patients treated in the hypothyroid state just before the therapeutic dose was given.

RESULTS

After 1 year both groups were studied by using whole-body scintigraphy (WBS) and measuring thyroglobulin after rhTSH. In group 1, WBS was negative in 76.9% (40 patients), while thyroglobulin-stimulated levels were <1.0 ng . ml(-1) in 86.5% (45 patients). In Group 2, WBS was negative in 75.6% (31 patients), while thyroglobulin-stimulated levels were <1 ng . ml(-1) in 78.0% (32 patients). (131)I uptake was 2.29+/-0.45 in the group treated with the aid of rhTSH, and 3.30+/-0.7 in the group treated in the hypothyroid state (P=0.2). No patients treated with the aid of rhTSH and with the short stoppage of L-T4 experienced symptoms of hypothyroidism, and free thyroxine (FT4) and thyroid-stimulating hormone levels remained normal.

CONCLUSIONS

Our data confirm that, when the interference of iodine is minimized, rhTSH is highly effective for the treatment of post-surgical thyroid remnants using a low dose of (131)I.

Authors+Show Affiliations

Spedali Riuniti di Livorno, Italy. danielebarbaro@katamail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

16829763

Citation

Barbaro, Daniele, et al. "Recombinant Human Thyroid-stimulating Hormone Is Effective for Radioiodine Ablation of Post-surgical Thyroid Remnants." Nuclear Medicine Communications, vol. 27, no. 8, 2006, pp. 627-32.
Barbaro D, Boni G, Meucci G, et al. Recombinant human thyroid-stimulating hormone is effective for radioiodine ablation of post-surgical thyroid remnants. Nucl Med Commun. 2006;27(8):627-32.
Barbaro, D., Boni, G., Meucci, G., Simi, U., Lapi, P., Orsini, P., ... Mariani, G. (2006). Recombinant human thyroid-stimulating hormone is effective for radioiodine ablation of post-surgical thyroid remnants. Nuclear Medicine Communications, 27(8), pp. 627-32.
Barbaro D, et al. Recombinant Human Thyroid-stimulating Hormone Is Effective for Radioiodine Ablation of Post-surgical Thyroid Remnants. Nucl Med Commun. 2006;27(8):627-32. PubMed PMID: 16829763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recombinant human thyroid-stimulating hormone is effective for radioiodine ablation of post-surgical thyroid remnants. AU - Barbaro,Daniele, AU - Boni,Giuseppe, AU - Meucci,Giuseppe, AU - Simi,Umberto, AU - Lapi,Paola, AU - Orsini,Paola, AU - Pasquini,Cristina, AU - Turco,Anna, AU - Mariani,Giuliano, PY - 2006/7/11/pubmed PY - 2006/10/25/medline PY - 2006/7/11/entrez SP - 627 EP - 32 JF - Nuclear medicine communications JO - Nucl Med Commun VL - 27 IS - 8 N2 - OBJECTIVE: To investigate whether recombinant human thyroid-stimulating factor (rhTSH) is effective for the radiometabolic ablation of post-surgery thyroid remnants, using low doses of (131)I. PATIENTS AND METHODS: The study included two groups of patients enrolled consecutively: group 1 consisted of 52 patients with papillary cancer or minimally invasive follicular cancer (stage I and II), and group 2 consisted of 41 patients with the same stage of disease. All patients underwent a total thyroidectomy. Group 1 received 1.11 GBq (30 mCi) (131)I for post-surgical remnants ablation with the aid of rhTSH, while group 2, in the hypothyroid state, received the same amount of radioiodine. To minimize iodine interference, all patients remained on a low iodine diet for 2 weeks and L-thyroxine (L-T4) was stopped for 4 days in the group of patients treated with the aid of rhTSH. To investigate (131)I uptake in this group, a tracer dose was administered 3 h after the second injection of rhTSH and the uptake was evaluated at 24 h just before administration of the therapeutic dose. I was also measured in the patients treated in the hypothyroid state just before the therapeutic dose was given. RESULTS: After 1 year both groups were studied by using whole-body scintigraphy (WBS) and measuring thyroglobulin after rhTSH. In group 1, WBS was negative in 76.9% (40 patients), while thyroglobulin-stimulated levels were <1.0 ng . ml(-1) in 86.5% (45 patients). In Group 2, WBS was negative in 75.6% (31 patients), while thyroglobulin-stimulated levels were <1 ng . ml(-1) in 78.0% (32 patients). (131)I uptake was 2.29+/-0.45 in the group treated with the aid of rhTSH, and 3.30+/-0.7 in the group treated in the hypothyroid state (P=0.2). No patients treated with the aid of rhTSH and with the short stoppage of L-T4 experienced symptoms of hypothyroidism, and free thyroxine (FT4) and thyroid-stimulating hormone levels remained normal. CONCLUSIONS: Our data confirm that, when the interference of iodine is minimized, rhTSH is highly effective for the treatment of post-surgical thyroid remnants using a low dose of (131)I. SN - 0143-3636 UR - https://www.unboundmedicine.com/medline/citation/16829763/Recombinant_human_thyroid_stimulating_hormone_is_effective_for_radioiodine_ablation_of_post_surgical_thyroid_remnants_ L2 - http://dx.doi.org/10.1097/00006231-200608000-00005 DB - PRIME DP - Unbound Medicine ER -