Tags

Type your tag names separated by a space and hit enter

Susceptibility of laboratory and wild rodents to Rattus or Apodemus-type hantaviruses.
Acta Virol. 1991 Jan; 35(1):54-63.AV

Abstract

Adult Wistar rats (Rattus norvegicus), Apodemus agrarius, Meriones unguiculatus, Clethrionomys rufocanus, and Apodemus argenteus were inoculated with Rattus-type (SR-11, KI-262, and TB-314) or Apodemus-type (Hantaan 76-118) hantaviruses. Production of serum antibody to the inoculated virus (IAHA titres of 1:32 to 1:4 096) was obsersved in all rodent species 10 weeks after virus inoculation. Rattus-type virus was detected in some organs of all the rodent species employed except of Apodemus agrarius. Apodemus-type virus was found only in some organs of Apodemus agrarius. Newborn Wistar rats induced antibody in high titres to both Rattus- and Apodemus-type hantaviruses. Rattus-type virus was detected in all the organs examined for up to 6 weeks after inoculation, whereas Apodemus-type virus disappeared from all organs except of brain and lung tissues. The virulence of the three Rattus-type viruses to newborn rats was different. These findings indicate that the susceptibility of rodents may vary depending on the combination of rodent species and virus strains; they also suggest that the various species of rodents may be the reservoir animals of hantavirus infection in nature.

Authors+Show Affiliations

Department of Veterinary Public Health, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1683116

Citation

Kawamura, K, et al. "Susceptibility of Laboratory and Wild Rodents to Rattus or Apodemus-type Hantaviruses." Acta Virologica, vol. 35, no. 1, 1991, pp. 54-63.
Kawamura K, Zhang XK, Arikawa J, et al. Susceptibility of laboratory and wild rodents to Rattus or Apodemus-type hantaviruses. Acta Virol. 1991;35(1):54-63.
Kawamura, K., Zhang, X. K., Arikawa, J., Takashima, I., Dempo, K., & Hashimoto, N. (1991). Susceptibility of laboratory and wild rodents to Rattus or Apodemus-type hantaviruses. Acta Virologica, 35(1), 54-63.
Kawamura K, et al. Susceptibility of Laboratory and Wild Rodents to Rattus or Apodemus-type Hantaviruses. Acta Virol. 1991;35(1):54-63. PubMed PMID: 1683116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptibility of laboratory and wild rodents to Rattus or Apodemus-type hantaviruses. AU - Kawamura,K, AU - Zhang,X K, AU - Arikawa,J, AU - Takashima,I, AU - Dempo,K, AU - Hashimoto,N, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 54 EP - 63 JF - Acta virologica JO - Acta Virol. VL - 35 IS - 1 N2 - Adult Wistar rats (Rattus norvegicus), Apodemus agrarius, Meriones unguiculatus, Clethrionomys rufocanus, and Apodemus argenteus were inoculated with Rattus-type (SR-11, KI-262, and TB-314) or Apodemus-type (Hantaan 76-118) hantaviruses. Production of serum antibody to the inoculated virus (IAHA titres of 1:32 to 1:4 096) was obsersved in all rodent species 10 weeks after virus inoculation. Rattus-type virus was detected in some organs of all the rodent species employed except of Apodemus agrarius. Apodemus-type virus was found only in some organs of Apodemus agrarius. Newborn Wistar rats induced antibody in high titres to both Rattus- and Apodemus-type hantaviruses. Rattus-type virus was detected in all the organs examined for up to 6 weeks after inoculation, whereas Apodemus-type virus disappeared from all organs except of brain and lung tissues. The virulence of the three Rattus-type viruses to newborn rats was different. These findings indicate that the susceptibility of rodents may vary depending on the combination of rodent species and virus strains; they also suggest that the various species of rodents may be the reservoir animals of hantavirus infection in nature. SN - 0001-723X UR - https://www.unboundmedicine.com/medline/citation/1683116/Susceptibility_of_laboratory_and_wild_rodents_to_Rattus_or_Apodemus_type_hantaviruses_ DB - PRIME DP - Unbound Medicine ER -