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[Epidemiological study of clinical characteristics of Chinese Han ethnic women with polycystic ovary syndrome].
Zhonghua Fu Chan Ke Za Zhi 2006; 41(6):375-9ZF

Abstract

OBJECTIVE

To carry out an epidemiological study of clinical characteristics of Chinese Han ethnic women with polycystic ovary syndrome (PCOS).

METHODS

According to Revised 2003 European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine criteria, PCOS can be diagnosed with 2 manifestations out of oligo-or anovulation, clinical and/or biochemical signs of hyperandrogenism exclusion of other etiologies and polycystic ovaries. One thousand and twenty-seven women in reproductive age from one area in Jinan city were investigated and the clinical, metabolic characteristics of the PCOS patients were analyzed.

RESULTS

(1) A total of 828 questionnaires were collected from 1027 women; the response rate was 80.62%. Eighty-five PCOS patients were diagnosed; PCOS accounted for 97.65% (83/85) in <or= 35 years old population groups; (2) Clinical manifestations were different between PCOS groups and controls in each age stage (P < 0.05); Menstruation, body hair Ferriman-Gallny (F-G) score, acne, ovarian follicle numbers decreased with aging among PCOS groups, and menstruation cycle was longer, testosterone (T), free androgen index (FAI) and ovarian follicle numbers were higher, sex hormone-binding globulin (SHBG) was lower than control groups of the same age respectively (P < 0.01); (3) Homeostasis model assessment-insulin resistance (Homa-IR) index in infertility PCOS group was higher than in fertility group (1.49 +/- 0.73 vs 1.31 +/- 0.66; t = 2.058; P < 0.05); fasting insulin, fasting blood glucose in obesity PCOS group was higher than in non-obesity group (8.50 +/- 3.46 vs 5.7 +/- 2.3, t = 2.984; P < 0.01, 5.45 +/- 0.54 vs 4.88 +/- 0.45, t = 2.891; P < 0.01), in contrast, insulin sensitivity index was lower in obesity PCOS group than in non-obesity group (0.025 +/- 0.015 vs 0.044 +/- 0.026; t = 2.292, P < 0.05).

CONCLUSIONS

(1) PCOS mainly distributes in <or= 35 years old population; (2) clinical manifestations of oligo-ovulation, clinical and/or biochemical signs of hyperandrogenism, polycystic ovaries of PCOS change with age increase. (3) PCOS with infertility and obesity is usually associated with glucose metabolic changes, especially insulin resistance.

Authors+Show Affiliations

Reproductive Medicine Center, Shandong Provincial Hospital, Shandong University, Ji'nan 250021, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16831357

Citation

Zhao, Jun-li, et al. "[Epidemiological Study of Clinical Characteristics of Chinese Han Ethnic Women With Polycystic Ovary Syndrome]." Zhonghua Fu Chan Ke Za Zhi, vol. 41, no. 6, 2006, pp. 375-9.
Zhao JL, Chen ZJ, Zhao LX, et al. [Epidemiological study of clinical characteristics of Chinese Han ethnic women with polycystic ovary syndrome]. Zhonghua Fu Chan Ke Za Zhi. 2006;41(6):375-9.
Zhao, J. L., Chen, Z. J., Zhao, L. X., Geng, L., Wang, S., Gao, S. S., ... Zhou, F. R. (2006). [Epidemiological study of clinical characteristics of Chinese Han ethnic women with polycystic ovary syndrome]. Zhonghua Fu Chan Ke Za Zhi, 41(6), pp. 375-9.
Zhao JL, et al. [Epidemiological Study of Clinical Characteristics of Chinese Han Ethnic Women With Polycystic Ovary Syndrome]. Zhonghua Fu Chan Ke Za Zhi. 2006;41(6):375-9. PubMed PMID: 16831357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Epidemiological study of clinical characteristics of Chinese Han ethnic women with polycystic ovary syndrome]. AU - Zhao,Jun-li, AU - Chen,Zi-jiang, AU - Zhao,Li-xin, AU - Geng,Ling, AU - Wang,Shan, AU - Gao,Shan-shan, AU - Zhang,Peng, AU - Liu,Shan, AU - Zhou,Feng-rong, PY - 2006/7/13/pubmed PY - 2008/2/15/medline PY - 2006/7/13/entrez SP - 375 EP - 9 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 41 IS - 6 N2 - OBJECTIVE: To carry out an epidemiological study of clinical characteristics of Chinese Han ethnic women with polycystic ovary syndrome (PCOS). METHODS: According to Revised 2003 European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine criteria, PCOS can be diagnosed with 2 manifestations out of oligo-or anovulation, clinical and/or biochemical signs of hyperandrogenism exclusion of other etiologies and polycystic ovaries. One thousand and twenty-seven women in reproductive age from one area in Jinan city were investigated and the clinical, metabolic characteristics of the PCOS patients were analyzed. RESULTS: (1) A total of 828 questionnaires were collected from 1027 women; the response rate was 80.62%. Eighty-five PCOS patients were diagnosed; PCOS accounted for 97.65% (83/85) in <or= 35 years old population groups; (2) Clinical manifestations were different between PCOS groups and controls in each age stage (P < 0.05); Menstruation, body hair Ferriman-Gallny (F-G) score, acne, ovarian follicle numbers decreased with aging among PCOS groups, and menstruation cycle was longer, testosterone (T), free androgen index (FAI) and ovarian follicle numbers were higher, sex hormone-binding globulin (SHBG) was lower than control groups of the same age respectively (P < 0.01); (3) Homeostasis model assessment-insulin resistance (Homa-IR) index in infertility PCOS group was higher than in fertility group (1.49 +/- 0.73 vs 1.31 +/- 0.66; t = 2.058; P < 0.05); fasting insulin, fasting blood glucose in obesity PCOS group was higher than in non-obesity group (8.50 +/- 3.46 vs 5.7 +/- 2.3, t = 2.984; P < 0.01, 5.45 +/- 0.54 vs 4.88 +/- 0.45, t = 2.891; P < 0.01), in contrast, insulin sensitivity index was lower in obesity PCOS group than in non-obesity group (0.025 +/- 0.015 vs 0.044 +/- 0.026; t = 2.292, P < 0.05). CONCLUSIONS: (1) PCOS mainly distributes in <or= 35 years old population; (2) clinical manifestations of oligo-ovulation, clinical and/or biochemical signs of hyperandrogenism, polycystic ovaries of PCOS change with age increase. (3) PCOS with infertility and obesity is usually associated with glucose metabolic changes, especially insulin resistance. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/16831357/[Epidemiological_study_of_clinical_characteristics_of_Chinese_Han_ethnic_women_with_polycystic_ovary_syndrome]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0529-567X&amp;year=2006&amp;vol=41&amp;issue=6&amp;fpage=375 DB - PRIME DP - Unbound Medicine ER -