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Axonal polyneuropathy after acute dimethylamine borane intoxication.
Arch Neurol. 2006 Jul; 63(7):1009-12.AN

Abstract

OBJECTIVE

To study a patient with axonal polyneuropathy due to acute dimethylamine borane (DMAB) intoxication.

PATIENT

Confusion and drowsiness in the acute stage, followed by cognitive impairments and polyneuropathy, are reported in a chemical factory worker after acute exposure to DMAB.

RESULTS

Nerve conduction studies indicated axonal polyneuropathy, particularly in the motor nerves. Sural nerve biopsy studies 3 months later revealed an axonal degeneration with a mild decrease of fiber density in the large myelinated fibers. Quantitative sensory testing also disclosed an impairment of pinprick, temperature, and touch sensations. Cutaneous nerve biopsy studies 9 months later demonstrated a moderate loss of epidermal nerves. During the follow-up period of 1.5 years, the clinical features and serial nerve conduction studies showed a steady improvement.

CONCLUSIONS

Since DMAB is a new product and has been widely used recently in the manufacturing of semiconductors and electronics, we conclude that DMAB intoxication may produce motor-predominant axonal polyneuropathy and that the establishment of a threshold limit value is warranted.

Authors+Show Affiliations

Department of Neurology, Chang Gung Memorial Hospital and University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16831972

Citation

Kuo, Hung-Chou, et al. "Axonal Polyneuropathy After Acute Dimethylamine Borane Intoxication." Archives of Neurology, vol. 63, no. 7, 2006, pp. 1009-12.
Kuo HC, Huang CC, Chu CC, et al. Axonal polyneuropathy after acute dimethylamine borane intoxication. Arch Neurol. 2006;63(7):1009-12.
Kuo, H. C., Huang, C. C., Chu, C. C., & Chu, N. S. (2006). Axonal polyneuropathy after acute dimethylamine borane intoxication. Archives of Neurology, 63(7), 1009-12.
Kuo HC, et al. Axonal Polyneuropathy After Acute Dimethylamine Borane Intoxication. Arch Neurol. 2006;63(7):1009-12. PubMed PMID: 16831972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Axonal polyneuropathy after acute dimethylamine borane intoxication. AU - Kuo,Hung-Chou, AU - Huang,Chin-Chang, AU - Chu,Chun-Che, AU - Chu,Nai-Shin, PY - 2006/7/13/pubmed PY - 2006/8/8/medline PY - 2006/7/13/entrez SP - 1009 EP - 12 JF - Archives of neurology JO - Arch Neurol VL - 63 IS - 7 N2 - OBJECTIVE: To study a patient with axonal polyneuropathy due to acute dimethylamine borane (DMAB) intoxication. PATIENT: Confusion and drowsiness in the acute stage, followed by cognitive impairments and polyneuropathy, are reported in a chemical factory worker after acute exposure to DMAB. RESULTS: Nerve conduction studies indicated axonal polyneuropathy, particularly in the motor nerves. Sural nerve biopsy studies 3 months later revealed an axonal degeneration with a mild decrease of fiber density in the large myelinated fibers. Quantitative sensory testing also disclosed an impairment of pinprick, temperature, and touch sensations. Cutaneous nerve biopsy studies 9 months later demonstrated a moderate loss of epidermal nerves. During the follow-up period of 1.5 years, the clinical features and serial nerve conduction studies showed a steady improvement. CONCLUSIONS: Since DMAB is a new product and has been widely used recently in the manufacturing of semiconductors and electronics, we conclude that DMAB intoxication may produce motor-predominant axonal polyneuropathy and that the establishment of a threshold limit value is warranted. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/16831972/Axonal_polyneuropathy_after_acute_dimethylamine_borane_intoxication_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.63.7.1009 DB - PRIME DP - Unbound Medicine ER -